I am in the field with experts such as Dr Mettiere from Springfield Missouri. I am now starting to work with reseachers and clinicians in regards to new studies from Dr Navaux in regards to advancements in the cell danger response. We are currently finding ways to modulate CDR1,2,3 with emphasis of the impact of NRF2 on multiple systems
Please keep us updated on the progress. Ive spent a lot of time at Longecity and reading whats been published by the National Institutes of Health. At this point I would still only consider an I.V
NAD+ booster. Ive been following other promising substances besides rapamycin and Metformin. Such as Dasatanib, beta lapashone, Fox04-DRI, and many others.
Theres a lot of promising research which looks to be taking a while to reach the clinical trial stage. I know Chromadex is seeking FDA approval for a prescription NR. I for one seriously hope they get slapped down.
The American pharmaceutical industry is resembling mobsters more and more with each passing day. The scandals and price increases in brand and generic drugs these last few years are atrotious. This is one of the main reasons for ridiculous increases in health insurance premiums the last 10 to 12 years.
Once something clears the FDA, we have to deal with all the marketing and pricing aspects. Anything marketed as a geroprotector or antidegenerative medication may be prohibitively expensive.
Right now we can cut out sugars, drink water, avoid excessive sun exposure, move to a Mediterranean diet. Take substances which activate Sirt 1. Eliminate alchohol and tobacco products. Work out and hold down body fat. Supplement to lower cortisol and much more. C60 may turn out to be the next big super antioxidant.
Personally, I believe Dr. Alan Green is on the right track. Rapamycintherapy.com is a great website that breaks down the benefits of metformin, rapamycin, ARBs, and aspirin.
John Mitteldorf and whoever runs Selfhacked are also two excellent resources. They remain on the cutting edge of anti aging science.
I stand by what I said in regards to both oral NR and NMN. There are too many unknowns. Is it effective and if so how much? What are the side effects? What is the bioavailability? These are only a few examples but, you get the picture.
I would tell someone who needs more energy to look into b-12 and some of the amino acids which are cheaply available.