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Will Ketotifen help reset caffiene tolerance?

That my friend comes from taking time off
 
How much time do you lot need to recover / be able to use moderate doses of caffeine and are more sensitive to its effects.
 
I would say a month. Depends entirely on your body and how stim tolerant you are.
 
Caffeine tolerance is a combination of:

Upregulation of adenosine receptors
Up regulation of the CYPs that metabolize caffeine

The latter can be addressed by inhibitors, but you're SOL with the former phenomenon
 
niclas90 said:
Nope. It helps your body metabolise it faster, thus removing the effects after consuming caffeine.
It does nothing for tolerance.
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The sooner all caffeine is metabolized out of your body, I would *think* the sooner the two things cooper listed could start occurring. I didn't mean to imply that you should just take RC and you'll be good to go, instant receptor reset. I've done one CAF break already and remember the miserable first week - I'm due for another in June and will use RC, so we'll see if it helps in any way.
 
If you take time off of caffeine and supplement with an Adrenal Restore product, it shouldn't take an extremely long time. I think GAT has one. And a St. Louis company called 1stPhorm has one that is awesome.
 
toddmuelheim said:
STOP LEAVING US
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Life's been busy...but so good :)

Bossmoss94 said:
If you take time off of caffeine and supplement with an Adrenal Restore product, it shouldn't take an extremely long time. I think GAT has one. And a St. Louis company called 1stPhorm has one that is awesome.
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If you see above, caffeine tolerance is unrelated to adrenal hormone stores.

Caffeine -> adenosine receptor blockade -> (several steps) -> adrenergic receptor stimulation

In response to prolonged caffeine intake, the adenosine receptor upregulates and the adrenergic receptor downregulates (this last part is hypothesized in many papers but I've yet to seen it demonstrated unless I've missed a new study).

Regardless, there isn't a loss of adrenal hormone (NE/E) stores. The body can produce these hormones very rapidly, hence why when you exercise (or do any other "fight or flight" stuff), you don't turn into a burnt out, sleepy old man. These hormones are able virtually on demand at any time in healthy individuals.

So taking an adrenal restoration product, which usually contains something like pantothenic acid and bovine adrenals (both of which can theoretically help produce more adrenal hormones), won't affect the cause of the caffeine tolerance. Pregnenolone and rhodiola may ease the transition, but they're not resetting tolerance, they're just acting as mood boosters.
 
Here's a good read:

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This breaks down everything related to caffeine.

(Don't use paraxanthine for fat loss, caffeine is a prodrug to it anyway).

Of note, smoking increases caffeine tolerance and estrogen decreases it
 
mr.cooper69 said:
Caffeine tolerance is a combination of:

Upregulation of adenosine receptors
Up regulation of the CYPs that metabolize caffeine

The latter can be addressed by inhibitors, but you're SOL with the former phenomenon
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WHERE IN THE BLUE F*€K HAVE YOU BEEN COOPER?????
 
I know it is VERY popular for people that use clen as it helps from building up a tolerance
 
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