hey guys another post.
Was just wondering whats everyones thoughts about MK-677 is this a placebo waste of money, or does this produce any GH results. And fyi before any says stuff. I've run GHRP6/GHRP2/ CJC dac, CJC 1295 and sermorelin, so yes i have an extensive knowledge on GH.
My question is: Does MK-677 compare to these, is it less side effects/ less dangerous or more dangerous? MK-677 seems like a rather new drug, compared to GHRP6 which has been around since like 1960 and has quite the extensive studies, making it quite safe. I've heard it has a 24 hr life, so thats quite easy for life. No pinning 3x a day or more lol.
reason for using: to gain a bit of muscle, lose a bit of body fat, Heal up my joints and train longer in the gym etc. You know the awesome feelings you get on GH of course.
How does cycling/duration/dosage go on this? read 10mg for 6 months, or 20mg whichever you prefer. pretty interesting data on this, read it can reduce tumors in rats.
This thread is good to read :
Invalid Link Removed
Some of things I wrote before about MK677:
MK677 is GHRP and not GHRH.
Like I said, it is an oral Growth Hormone secretagogue/Ghrelin mimetic and it binds to a totaly different receptor called Growth Hormone Secretagogue Receptor. Main action of all GHRP drugs such as GHRP-2,GHRP-6, Ipamorelin ,MK677 Etc).
GHRH binds to the Growth Hormone Releasing Horomne Receptor (GHRHR) such as CJC.
MK677 is a good REM sleep Booster and there is a study proving it but I do recommend to run MK677 longer than 2 months.(like many people run this) Actually the first months are most "critical"now i am thinking of Insulin sensitivity decrease. After couple of months, insulin sensitivity increases.
Some do use Huperzine A for Somatostatin Inhibition but honestly I dont think it is nessesary since it bypass the somatostatin barrier by interacting directly with GH receptors, thus producing GH release (something I wrote before in SARMs Thread)
It is very different how people respond to this compound but here is some tips:
-increased GH leads to increased sodium and water-retention. Make sure the sodium intake is at minimum !
Potassium could help and for those with horrible water-retention, ibuprofen (3×400mg daily) can actually help a lot.(according to a study). But ibuprofen should be used in worst cases because Cox inhibitors are decreasing beneficial anabolic prostaglandin actions which can lower muscle protein synthesis.
-Ghrelin mimetic/synthetic ghrelin analogues increase or works like ghrelin (hunger hormone). Appetite-increase is normal and that is a huge bonus. Easier to throw in more healthy/clean food.
-increased GH does increase REM sleep. Many users are reporting better sleep on MK677 and there is a study showing REM sleep increase (50%).
- Increased Lethargy is pretty normal when GH levels are increased. It can be due to lower insulin sensitivity / insulin resistance (higher bloodsugar levels makes you more tired/lethargic). A good diet could do the trick. Remember, there is a study showing Mk677 lower insulin sensitivity 2 first months and then it stabilizes (goes back to normal).
Increased GH can have negative impact on the thyroid function, and can cause lethargy. I am not saying it would be good idea to play with T4 or a combo of T3 and T4. (Hypothyroidism is more normal with higher doses of HGH).
Some people are feeling better when they dose MK677 prior bedtime than in the morning.
-hand numbness.
"MK677 is increasing growth hormone and it has the ability to increase muscle and tissue mass, it frequently causes compression of the nerves. The most common nerve compression syndrome induced by growth hormone is the carpal tunnel syndrome. The major nerve in the hand (median nerve) which travels down the arm is squeezed between the fibrous bands and the muscles in the hand. This painful condition causes tingling, numbness and weakness of the fingers and the hand."
"however, it is mediated via impact of GH on peripheral fluid retention around the applicable nerves. (GH affects fluid retentionvia RAAS and ENaC mechanisms)."
Lowering the dose could do the trick
MK677 is mild on sides(compared to other GHRPs) and I was amazed how good it worked for my friends (25mg daily 100-120days).
If you experience water retention then you should really check your diet (sodium intake).
. Then shoot 100mcg of both 3x a day and watch what real GH feels like