Restoring Pregnenolone Deficiency

My initial thoughts:
-More isn't better overall. I wouldn't take it everyday. 2-3 the times a week is what I follow.
- have you had a cortisol test? Most hormone doctors and endos will test it with DHEAS because high cort can effect DHEA levels even with supplementation.
- creams and transdermal, but I realize you say it isn't an option, so forget that. However, it would probably have the biggest effect if sublingual is increasing e2 too much.
- An AI could also be incorporated
 
kisaj said:
My initial thoughts:
-More isn't better overall. I wouldn't take it everyday. 2-3 the times a week is what I follow.
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That is something to consider.

Curious to know your thoughts or experience - suppose I get my levels up to the upper limit and drop back my dose to "maintenance" - how well does the body retain it's DHEA-S level. My point is: I may be willing to consider tolerating the aromitization for another month or so if when I drop back to a maintenance dose my DHEA-S levels are sustainable and the aromatization is diminished.
- have you had a cortisol test? Most hormone doctors and endos will test it with DHEAS because high cort can effect DHEA levels even with supplementation.
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Cortisol - 10ug/dl @3:00pm (am 5-25ug/dl - pm approx half of am value?)
- creams and transdermal, but I realize you say it isn't an option, so forget that. However, it would probably have the biggest effect if sublingual is increasing e2 too much.
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With wife and daughter I'd prefer not to if at all possible.
- An AI could also be incorporated
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Yes, it is a consideration.

Thanks for the feedback.
 
Normal blood levels of DHEA-sulfate can differ by sex and age.

Typical normal ranges for males are:

  • Ages 18 - 19: 108 - 441 ug/dL
  • Ages 20 - 29: 280 - 640 ug/dL
  • Ages 30 - 39: 120 - 520 ug/dL
  • Ages 40 - 49: 95 - 530 ug/dL
  • Ages 50 - 59: 70 - 310 ug/dL
  • Ages 60 - 69: 42 - 290 ug/dL
  • Ages 69 and older: 28 - 175 ug/dL


Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different specimens. Talk to your doctor about the meaning of your specific test results.

I suppose if I could consider the saying "if you want to feel like you are in your twenties you need levels like you are in your twenties..."
 
David Dunn said:
That is something to consider.

Curious to know your thoughts or experience - suppose I get my levels up to the upper limit and drop back my dose to "maintenance" - how well does the body retain it's DHEA-S level. My point is: I may be willing to consider tolerating the aromitization for another month or so if when I drop back to a maintenance dose my DHEA-S levels are sustainable and the aromatization is diminished.
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That is exactly what I was told to do. I was told to supplement 100mg daily for 30 days and retest, but I only made it about 20 days if I remember correctly because I started getting really greasy and breaking out. So I tested early and I was right at the very top of the range. I then backed down to 50mg and then 25mg. It keeps me in the 75% range and where I walk the balance of seeing all the benefits and few, if any, sides.
 
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kisaj said:
That is exactly what I was told to do. I was told to supplement 100mg daily for 30 days and retest, but I only made it about 20 days if I remember correctly because I started getting really greasy and breaking out. So I tested early and I was right at the very top of the range. I then backed down to 50mg and then 25mg. It keeps me in the 75% range and where I walk the balance of seeing all the benefits and few, if any, sides.
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i increased my daily dose to 100mg. I will run it that high as tolerated for up to 30 days and retest. Hopefully it will be topped off and then at that time drop down to 50mg...25mg...and maintain.
 
David Dunn said:
Got new blood work numbers today for DHEA-S and E2

Start:

Today after 30 days at 50mg/d DHEA:
Estradiol (8-43) - 43.9
DHEA-S (95-530) - 315.7
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30 days of DHEA 100mg/d

DHEA-S (95-530) - 274.4

This is quite interesting as it is lower than when at 50mg/d. My speculation is the peak plasma levels and half life are influencing the blood work results. I did not dose any that day prior to the test. I can only speculate that it influenced my peak levels and therefore resulted in a lower result than when tested @50mg taken day of rest.

I did not test for E2 because it stands to reason that it should at least be equally elevated as last tested.

I'm challenged to see the fruitfulness in continuing to dose at 100mg or even at 50mg as I do not see any anecdotal benefit to it and would rather not use an AI to eleviated elevated E2.

I'm dropping down to 25mg/d hear on out and will test DHEA-S and E2 in another 30 days.

I'll be seeing my doctor to get s follow up test for pregnenolone as the online labs are not cost effective. Pregnenolone was my primary dificiency and will focus on this going forward.

Any insight or comments welcome.
 
David Dunn said:
30 days of DHEA 100mg/d

DHEA-S (95-530) - 274.4

This is quite interesting as it is lower than when at 50mg/d. My speculation is the peak plasma levels and half life are influencing the blood work results. I did not dose any that day prior to the test. I can only speculate that it influenced my peak levels and therefore resulted in a lower result than when tested @50mg taken day of rest.

I did not test for E2 because it stands to reason that it should at least be equally elevated as last tested.

I'm challenged to see the fruitfulness in continuing to dose at 100mg or even at 50mg as I do not see any anecdotal benefit to it and would rather not use an AI to eleviated elevated E2.

I'm dropping down to 25mg/d hear on out and will test DHEA-S and E2 in another 30 days.

I'll be seeing my doctor to get s follow up test for pregnenolone as the online labs are not cost effective. Pregnenolone was my primary dificiency and will focus on this going forward.

Any insight or comments welcome.
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I had simiale results dosing 25mg and 50mg. No real increase.
 
My values are not much more at 100mg than without any all.

Depending upon the lab and their range when I started at 244 I was over the high limit. I see no need to subject myself to aromatization for a negligible increase and indistinguishable anecdotal benefits.

Back to 25mg/d and hopefully an E2 in range again.
 
David Dunn said:
My values are not much more at 100mg than without any all.

Depending upon the lab and their range when I started at 244 I was over the high limit. I see no need to subject myself to aromatization for a negligible increase and indistinguishable anecdotal benefits.

Back to 25mg/d and hopefully an E2 in range again.
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My values were around 350 without, with 25mg/d, and with 50mg/d oral dosing.
 
Now I'm really interested in this thread. I just had bloodwork and the Pregnenolone was 27 LabCorp with no reference range listed. DHEA was 271. Thoughts?
 
Hey Dunn, how are your cortisol numbers? This sounds like possible pregnenolone steal on the surface but hard to say with just preg and DHEA numbers since they aren't bad, just not as high as expected.
 
First of all reference

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It is a known fact Zinc deficiency interfere with vitamin A metabolism. Why when you look on intracellular testing zinc and A are usually very close proximity. Why macular degeneration not corrected by vitamin A is corrected by guess what.... zinc.

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I would highly suggest serum retinol along with RBC zinc. When you doctor says you levels are normal. Most likely he has no clue about true health levels which prevent a functional deficiency. I worked on few thousand cases and have seen the correlation very high with this finding as well as the change in clinical markers showing enzyme associate with proper zinc metabolism resulting in therapeutic out come

Also reference
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NADH is also needed for the 3 11 17 21 beta-hydroxysteroid dehydrogenase function which does what? Its need to convert your the whole hormonal cascade. What does this identify? You may have a defect in your mitochondrion pathway Complex I and III.

The problem is that you are getting stuck in the NADH/NAD conversion which could be for various reason.
 
kisaj said:
Hey Dunn, how are your cortisol numbers? This sounds like possible pregnenolone steal on the surface but hard to say with just preg and DHEA numbers since they aren't bad, just not as high as expected.
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What causes pregnenolone steal? Is it related to high cortisol? My cortisol levels are good but my preg levels are low. Should get my bloodwork back Friday to see if preg went up.
 
Simple correcting proper sleep hygiene can increase dhea by 50%
 
Cool. You are very thorough, that is great. Just brainstorming here, but if you feel well, then the numbers (like TRT) may not matter so much.
 
sammpedd88 said:
I tried sublingual and my pregnenolone levels dropped from 209 to 17 in three months. For some reason sublingual doesn't work for me. I'm actually taking 200 mgs of oral pregnenolone a day to get my levels back up. I think they are getting where they need to be. I can tell if I'm having slight ED issues and my test and E2 are in check that it's my pregnenolone level being low. Now they are getting back up I'm having zero ED issues and could have sex two or three times a day!
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This is me right now! ED issues from out of the blue just this past week. Pregnenolone level is 27 and my test, free test, DHEA and E2 are in control . What brand Pregnenolone are you using?
 
kisaj said:
Cool. You are very thorough, that is great. Just brainstorming here, but if you feel well, then the numbers (like TRT) may not matter so much.
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Thanks.

Ten days back down to 25mg/d of DHEA. My concern going forward is not my DHEA-S value being raised any higher than it was "naturally" as 50mg/d raised my E2 and ironically 100mg/d did not change my DHEA-S value. I do not want to use an AI and 50mg-100mg/d did nothing to raise my values significantly enough to even merit its use.

I'm three months in on 100mg/d of pregnenolone. I'm going to have to schedule a doctor appointment (unless she'll write a lab order by phone request) because I cannot find a private test for less than $140.

Additionally I'm coming to believe that this Invalid Link Removed has been my issue (symptomatically) all along. After 3 days using ferritin supplements I felt improved. After 30 days, very significantly improved.
 
If people are using linear logic they will rarely solve the problem.
 
kenpoengineer said:
This is me right now! ED issues from out of the blue just this past week. Pregnenolone level is 27 and my test, free test, DHEA and E2 are in control . What brand Pregnenolone are you using?
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The sublingual brand was Source Natural. The oral brand was Life Extension. My dr just switched brands of oral called Health as it Ought to Be. I've been on it for a little over a month. I'm curious to see what my labs are with it.
 
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