You're too hard on yourself! The write ups aren't claiming that these compounds have never been used anywhere before, but many times we use them to highlight ingredients that are novel to supplements. It's also a way to explain why ingredients have been included rather than just telling the customers to blindly trust a company. Thanks to forums like AM, supplement users are a lot more educated these days and want to know what the justification is behind combining ingredients together rather than just throwing a bunch of random ingredients together. A lot of research goes into the creation of PES products and the write ups reflect that.