Glut-4 Muscle Cell Growth

[Jakethaniel]

I am not going to pretend to say that anything in this is correct, but I had been researching ALA and then I was telling my Grandma about fat cell mitosis and the idea just popped into my head. So please be open minded and if I am way off, I apologize.
I am putting this under supplements because if my theory is correct then I think supplements that increase Glut-4 transporters on muscle cells could be the future of supplementation for bulking.

So when a fat cell is full it undergoes mitosis, this makes sense because its job is storage and when it functions correctly it will work with insulin until it is full then eventually split so that blood glucose levels can be stabilized through storage.

Muscle cells' function is not primarily storage, so it makes sense as to why these cells are not as readily filled to their full capacity as I understand that fat cells are. Training increases this ability through hypertrophy which increases storage capacity and by increasing insulin sensitivity in the cells, but still their main function is not storage so they do not get as close to their capacity as fat cells do.

Now my theory is that if muscle cells could be filled past their supposed capacity, through a heavy increase in Glut-4 receptors on muscle cells, I believe this could cause more satellite cells to have to then mature into myoblasts which would either create new fibers or combine to the muscle cells which are at full capacity to combat the increased requirement for storage.
This idea would be under the idea that the dramatic swelling of the muscle cells could actually cause damage itself.

My original theory was under the idea that somehow muscle cell mitosis could occur through heavily increased storage caused by increased Glut-4 receptors, but now I do not find that nearly as feasible as the theory above.

 

[Driven2lift]

This is what GDA's are for.
Look into Recompadrol write up for a lot of extra info

And already existing natty anabolics, like Anabeta.

It is very interesting I am with you. The only issue is that a lot of the compounds with this effect are also powerful antioxidants (such as the ALA you mentioned) and blunt the hypertrophy response.

Some things seem to only improve shuttling to muscle like anacyclus pyrethrum without the antioxidant assault screwing with it

 

[LeanEngineer]

I would suggest looking into anabeta by pes as welll. It seems to be a pretty popular product at Strong Supplement Shop with a lot of good reviews. Check it out at the link.
Invalid Link Removed

 

[Jakethaniel]

Actually I am working on my own nutrient partitioning blend. I had posted looking for a company to work with on it a while ago, but it got taken down. Now I am looking more into Glut-4 to perfect it, for at least personal use.

Invalid Link Removedlooks VERY interesting, but it is not in any current products.
Curcumin also looks to be very promising as well.
Few other things I am looking into also.

I think as long as it is taken post workout the amount of antioxidants in most of the things I am looking into should not inhibit protein synthesis, especially if you include something like leucine with it prior to food..

 

[Driven2lift]

Glut-4 is already optimized in all the best ways possible post-workout

Its a general consensus that using GDAs or anything of the sort here is a waste, or in some cases counter productive

 

[Driven2lift]

You should have a chat with EBF Inc

The pro in these matters

 

[TyMan14]

Subbed for more info..

 

[Jakethaniel]

Glut-4 is already optimized in all the best ways possible post-workout

Its a general consensus that using GDAs or anything of the sort here is a waste, or in some cases counter productive

I was mainly looking/theorizing on the idea of increasing Glut-4 receptors on the muscle cells causing them to swell to the point, or even past it, that for instance a fat cell would have to undergo mitosis capacity wise.
Whether this would then cause its own form of growth through creating damage, new muscle cells being created from satellite cells, or an unknown possibility for muscle cell mitosis, I do not know.

So my thinking was reduce insulin sensitivity in fat cells with St. John's Wort and flood the body with substances that increase Glut-4 receptors while it is already in the state that as you mentioned the muscle cells' Glut-4 receptors are optimized and the cells are very insulin sensitive.

 

[EatMoar]

Glut-4 is already optimized in all the best ways possible post-workout Its a general consensus that using GDAs or anything of the sort here is a waste, or in some cases counter productive

True that, pointless post workout. The point of GdAs are to spike your insulin, which Intern will cause the uptake of the glut4 receptors to shuttle nutrients into your cells so they aren't roaming the blood to keep your blood glucose stable.

I remember taking the old purus labs slinshot and I forgot to eat, went straight hypo in 30 minutes in the mide of a store. Went up to the front and ate all their free jelly beans lol.

 

[RecompMan]

True that, pointless post workout. The point of GdAs are to spike your insulin, which Intern will cause the uptake of the glut4 receptors to shuttle nutrients into your cells so they aren't roaming the blood to keep your blood glucose stable. I remember taking the old purus labs slinshot and I forgot to eat, went straight hypo in 30 minutes in the mide of a store. Went up to the front and ate all their free jelly beans lol.

no, they stimulate glut 4 through the insulin pathway , and reduce overall insulin secretion

I wouldn't say pointless unless it only work on the insulin pathway similar to the old slinshot

When there are dual actions of products it can still be beneficial

 

[EatMoar]

no, they stimulate glut 4 through the insulin pathway , and reduce overall insulin secretion I wouldn't say pointless unless it only work on the insulin pathway similar to the old slinshot When there are dual actions of products it can still be beneficial

What would explain myself going hypo if my insulin secretion was hindered?

 

[Driven2lift]

What would explain myself going hypo if my insulin secretion was hindered?

It lowers insulin secretion because of the GLUT4 activation, (amoung other things)this is also why exercise represses it.

The purpose of a GDA is to get your body into a similar state to when having just finished exercise.

With GLUT-4 at the cell membrane nutrient shuttling is at full speed and insulin is no longer required to get energy into cells essentially.

Insulin is a response to high blood sugar and energy outside of where it can be stored/used, to shuttle it in to muscle/fat, etc.
This doesn't happen while your body is using the energy and in a state of creating free energy


^ is my basic explanation

 

[EatMoar]

It lowers insulin secretion because of the GLUT4 activation, (amoung other things)this is also why exercise represses it. The purpose of a GDA is to get your body into a similar state to when having just finished exercise. With GLUT-4 at the cell membrane nutrient shuttling is at full speed and insulin is no longer required to get energy into cells essentially. Insulin is a response to high blood sugar and energy outside of where it can be stored/used, to shuttle it in to muscle/fat, etc. This doesn't happen while your body is using the energy and in a state of creating free energy ^ is my basic explanation

So would gdas also be considered insulin mimickers for nutrient shuttling?

 

[Driven2lift]

So would gdas also be considered insulin mimickers for nutrient shuttling?

Exactly, Actually some stores sell them under that exact title
I know NutraPlanet did

 

[EatMoar]

Exactly, Actually some stores sell them under that exact title I know NutraPlanet did

I felt like I knew that but I'm so tired I can barley see my keyboard keys. Thanks for the info though fellas, always a pleasure learning something new

 

[RecompMan]

What would explain myself going hypo if my insulin secretion was hindered?

stimulates the pathway thus allowing the glucose to enter the cell

Highly doubt you went hypo

Did you test your sugars?

 

[EatMoar]

stimulates the pathway thus allowing the glucose to enter the cell Highly doubt you went hypo Did you test your sugars?

Ah no I just went by the fact I was cold sweating and felt
Light headed etc

 

[RecompMan]

Hey guys

Everyone I here is talking about glut4 translocation
Take a look at the in depth recompadrol write up

There is limited stock on this product and then it will no longer be manufactured (until or unless another company purchased the formulation for their line)

On sale at our website

extreme35 for 35% off

Thanks for continued support from all members on the board

 

[EatMoar]

Hey guys Everyone I here is talking about glut4 translocation Take a look at the in depth recompadrol write up There is limited stock on this product and then it will no longer be manufactured (until or unless another company purchased the formulation for their line) On sale at our website extreme35 for 35% off Thanks for continued support from all members on the board

Sorry to hear about that bud

 

[mr.cooper69]

You have a lot to learn OP...

 

[Jakethaniel]

You have a lot to learn OP...

Thanks for the great contribution to the discussion! hah
That is exactly why I said, "please be open minded and if I am way off, I apologize."

 

[mr.cooper69]

You're welcome

 

[rosemont83]

Hey guys

Everyone I here is talking about glut4 translocation
Take a look at the in depth recompadrol write up

There is limited stock on this product and then it will no longer be manufactured (until or unless another company purchased the formulation for their line)

On sale at our website

extreme35 for 35% off

Thanks for continued support from all members on the board

Aw man I liked recompadrol
Is there a reason for that?