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Just found out about transdermals...

alex25

New member
I always thought transdermals were illegal for the same reasons injectables are and you had to either make them yourself or buy them from riskier sources.

Well, I was wrong... and I was reading about transdermals and something just doesn't seem right.

Everything I've read says that they have better bioavailibility in comparison to orals and that your liver isn't nearly as taxed due to it not being passed through on the first pass... So why are orals even popular? Is there a catch or some downfall to transdermals that I haven't caught on to yet... because as far as I can tell, they're just as legal, safer, and more effective... and I'm assuming they could be run relatively safe for longer cycles than 6 weeks unlike orals.
 
You can accidentally contaminate your gf/wife/kids if you are careless with transdermals.
 
The liver part is bro science. Transdermals are no safer then orals and the question of them being more bioavailable is really a question of molecular weight and solubility.
 
harbonah said:
The liver part is bro science. Transdermals are no safer then orals and the question of them being more bioavailable is really a question of molecular weight and solubility.
Click to expand...

Huh? Can you post up where we can read on oral and transdermal being equal with regards to the liver and passing the same?

Transdermals are great, and depending on what kind it is, can have benefits over injection or oral.
 
jbryand101b said:
It all gets filtered via the liver.

Just skips first pass.

Hepatotoxicity will depend on the structural makeup.
Click to expand...

This is the correct statement.

Just because you put M1T into a transdermal doesn't mean it will be any less toxic, but with the 17a methyl group whats the point.

Transdermals are mainly for non methylated compounds with limits. Like Dienolone and Formestane have poor oral bioavailability so topical application straight to the blood stream works better, but intramuscular depot would still work the best. For something like trestolone with it's very rapid metabolism, a transdermals delayed absorption would help spread out blood concentration vs a rapid spike and plummit as with oral.
 
harbonah said:
The liver part is bro science. Transdermals are no safer then orals and the question of them being more bioavailable is really a question of molecular weight and solubility.
Click to expand...

Figured it sounded too good to be true. The lower toxicity would have been the main selling point for me. Thanks
 
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