Guest viewing limit reached
  • You have reached the maximum number of guest views allowed
  • Please register below to remove this limitation

GDAs - Your Favorite?

Driven2lift said:
I wish I had access to crazy new ingredients to take all the time.

Then play the "what's this gonna do" waiting game

Curious how many of these trials ended badly, or in GI distress, lol
Click to expand...

Not many,

Some had me painting the toilet but lowered dose corrected it,

I mainly play with GDAs, burners and pre workouts

All the above I have in the pipeline movig forward if I grow how I see I should this year
 
EBF Inc said:
Not many,

Some had me painting the toilet but lowered dose corrected it,

I mainly play with GDAs, burners and pre workouts

All the above I have in the pipeline movig forward if I grow how I see I should this year
Click to expand...

Would love to see EBF's take on a pre, I will be trying all of them I am sure though.
 
Driven2lift said:
Would love to see EBF's take on a pre, I will be trying all of them I am sure though.
Click to expand...

I have something I wanna bring to market,

Can be used with meals, and mixed with a pre workout stim for thermogenic/pump

It's a matter of if stim burner should be first, this product would be pretty revolutionary on terms of first of its kind on the category (which will not be spoke. Yet).

Thinkin the market it's pretty flooded with stim burners but what I been playin with is simple, to the point, and effective
 
I will pay you to beta test ;) lol


Stim love.

GDAs are the most complicated and therefor interesting supplements, my GDA stash has 5 different ones currently. And Metabolic Powder, whatever category that falls into.
 
Recompadrol, ill second the notion that when u eat carbs its like u didn't eat them...I could be stuffed, then eat carbs and its like I'm hungry again
 
GreenMachineX said:
Is Examiner's concern regarding berberine preventing muscle gain not valid?
Click to expand...

Sh1t I hope not, I just ordered recompadrol and it has a hefty dose of it. That would blow. I might hold of on taking it to do more research. Id like to hear some of the other members opinions if possible
 
Here's what is reported on 'examine's site:

Berberine can also reverse insulin resistance on muscle cells and promote both glucose and lipid uptake into the muscle cells. Unfortunately, the mechanism of action that mediates this (AMPK activation) also appears to suppress muscle growth and may actually reduce muscle mass according to one rodent study. Genetically ablating one protein (atrogin-1) reverses this suppression of muscle growth, and thus berberine has potential to be a potent body recomposition agent, pending future research. The interactions with exercise are unknown, but it is theoretically possible that resistance training or contracting muscle tissues can attenuate or reverse these losses.
 
Rostam said:
Here's what is reported on 'examine's site:

Berberine can also reverse insulin resistance on muscle cells and promote both glucose and lipid uptake into the muscle cells. Unfortunately, the mechanism of action that mediates this (AMPK activation) also appears to suppress muscle growth and may actually reduce muscle mass according to one rodent study. Genetically ablating one protein (atrogin-1) reverses this suppression of muscle growth, and thus berberine has potential to be a potent body recomposition agent, pending future research. The interactions with exercise are unknown, but it is theoretically possible that resistance training or contracting muscle tissues can attenuate or reverse these losses.
Click to expand...
Ugh I dont think I want to take this stuff. Maybe Ill send it back for a refund and go with biotests indigo 3cg. Its a rip off though but I want something that works
 
From the right up it says this..... Recompadrol has a potent effect of blocking fatty acid synthesis through ATP-Citrate Lyase, Wouldn't that be bad for something like ARA which is a fatty acid? Maybe even Phospatitc acid even though im not sure if that has anything to do with fatty acids but still what about ARA? It could bloke the uptake of it.
 
SauceMonkey22 said:
in for this, just bought recompadrol and burn24 to experiment with na-r-ala and both slin sanes
Click to expand...
Me too Im thinking of returning it now. Really wondering if it van block ARA since it blocks fatty acid according to write up. They got any reps on this board?
 
fightnews said:
Ugh I dont think I want to take this stuff. Maybe Ill send it back for a refund and go with biotests indigo 3cg. Its a rip off though but I want something that works
Click to expand...

Yeah, I might go with a GDA that doesn't have berberine in it until there's more discussion on it.
 
fightnews said:
Sh1t I hope not, I just ordered recompadrol and it has a hefty dose of it. That would blow. I might hold of on taking it to do more research. Id like to hear some of the other members opinions if possible
Click to expand...

Decent dose. I wouldn't be worried at all

Benefits outweigh potential issues with atrogin1.
 
fightnews said:
Ugh I dont think I want to take this stuff. Maybe Ill send it back for a refund and go with biotests indigo 3cg. Its a rip off though but I want something that works
Click to expand...

You need to re look at your research

A lot of things increase ampk

No worries with recompadrol
 
fightnews said:
From the right up it says this..... Recompadrol has a potent effect of blocking fatty acid synthesis through ATP-Citrate Lyase, Wouldn't that be bad for something like ARA which is a fatty acid? Maybe even Phospatitc acid even though im not sure if that has anything to do with fatty acids but still what about ARA? It could bloke the uptake of it.
Click to expand...

Nope due to effect on cd36

Your ok
 
Invalid Link Removed

Berberine does act on COX-2 and therefore to some extent inhibit the ARA effects.

That being said it is not a huge effect and I came across a few logs where users enjoyed running GDAs alongside ARA.

I would just not use a GDA preworkout personally anyways. Keep them for with large meals.
 
SauceMonkey22 said:
recompadrol for the win! 4 caps pre cheat meal = win according to my friend, very excited to try mine finally
Click to expand...

Make sure its a hell of a cheat lol

I've gone pretty overboard on a cheat before, Thanksgiving dinner. I have a mashed potato addiction.

Nothing 2 Recompadrol, 2 SsV2, and 2 AP couldn't handle.
 
SauceMonkey22 said:
Jeeze lol, i actually was curious on other carb dosing with recompadrol and Burn24, I have a thread posted if you can give it a look-see and give me your opinion Driven?
Click to expand...

Link me brother

I can speak from experience for most
 
Here's from mullet soldier on atrogin 1

"
Great question!

I unfortunately do not have access to this full journal, so my commentary will be mostly speculative at this time. This being said, I will address the comments as best as possible.

As we see from the abstract, it appears that berberine extract-induced decreased muscle protein synthesis and increased muscle protein degradation is dependent on an increased expression of both atrogin-1, a key proteolytic gene present in a variety of catabolic states, and eIF3-f, a key component of the mTOR activation pathway. At first blush, this obviously appears to be indefensibly negative, as the atrogin-1 induction was not dependent upon the Atk/PI3K transcription pathway, and is thus entirely the result of berberine.

With that being said, we need to remember an important fact: these were diabetic mice. Insulin resistance is often associated with an increased in the activity of the ubiquitin-proteasome proteolytic pathway, and in particular, the expression of atrogin-1 to promote muscle atrophy. The mechanisms here are complex, but for a reference, the expression of both atrogin-1 and atrogin-1 transcription promoters have been shown to be increased by 15 fold in insulin resistant states."
 
EBF Inc said:
Invalid Link Removed
Click to expand...
Thanks but that link is not very convincing. Not trying to be a negative nancy but Id rather not take anything that going to negatively impact hypertrophy and interfere with ARA even if it is only a little. Its not really worth it.
 
EBF Inc said:
Here's from mullet soldier on atrogin 1

"
Great question!

I unfortunately do not have access to this full journal, so my commentary will be mostly speculative at this time. This being said, I will address the comments as best as possible.

As we see from the abstract, it appears that berberine extract-induced decreased muscle protein synthesis and increased muscle protein degradation is dependent on an increased expression of both atrogin-1, a key proteolytic gene present in a variety of catabolic states, and eIF3-f, a key component of the mTOR activation pathway. At first blush, this obviously appears to be indefensibly negative, as the atrogin-1 induction was not dependent upon the Atk/PI3K transcription pathway, and is thus entirely the result of berberine.

With that being said, we need to remember an important fact: these were diabetic mice. Insulin resistance is often associated with an increased in the activity of the ubiquitin-proteasome proteolytic pathway, and in particular, the expression of atrogin-1 to promote muscle atrophy. The mechanisms here are complex, but for a reference, the expression of both atrogin-1 and atrogin-1 transcription promoters have been shown to be increased by 15 fold in insulin resistant states."
Click to expand...

PS:

Fasting increases atrogin 1 2-5 fold in muscles. Goin to stop if?

Nope!
 
EBF Inc said:
Here's from mullet soldier on atrogin 1

"
Great question!

I unfortunately do not have access to this full journal, so my commentary will be mostly speculative at this time. This being said, I will address the comments as best as possible.

As we see from the abstract, it appears that berberine extract-induced decreased muscle protein synthesis and increased muscle protein degradation is dependent on an increased expression of both atrogin-1, a key proteolytic gene present in a variety of catabolic states, and eIF3-f, a key component of the mTOR activation pathway. At first blush, this obviously appears to be indefensibly negative, as the atrogin-1 induction was not dependent upon the Atk/PI3K transcription pathway, and is thus entirely the result of berberine.

With that being said, we need to remember an important fact: these were diabetic mice. Insulin resistance is often associated with an increased in the activity of the ubiquitin-proteasome proteolytic pathway, and in particular, the expression of atrogin-1 to promote muscle atrophy. The mechanisms here are complex, but for a reference, the expression of both atrogin-1 and atrogin-1 transcription promoters have been shown to be increased by 15 fold in insulin resistant states."
Click to expand...

Yeah but it was shown in normal mice to
 
SauceMonkey22 said:
I think you're overthinking this a tad. Again caffeine has similar effects, and there's millions of people that build muscle taking a caffeine type supplement pre-wo.

Just don't dose the gda pre-wo if you're worried about ARA absorption
Click to expand...
your prob right but still i can live without it. something better will come along
 
You mean you guys haven't heard the hype?


Bedside glucose/amino IV's, gotta stay anabolic!
 
Late but here's my list

1- recompadrol best Gda hands down.
2- burn 24 better used with low carbs when cutting.
3- NaRALA mixed with top two
4- SSv2
 
Would burn24 or recompadrol work better when reverse dieting. Im leaning toward the burn24 since while reverse dieting you will still be in a deficit for a couple of weeks until you get up to maintenance?
 
NattyForLife said:
Would burn24 or recompadrol work better when reverse dieting. Im leaning toward the burn24 since while reverse dieting you will still be in a deficit for a couple of weeks until you get up to maintenance?
Click to expand...

Use recompadrol.

Burn 24 is not a bad product, and can be used but overall MOA recompadrol Is just different and more "complete"
 
Quadzilla99 said:
How much berberine is in yellow gold? Isn't that loaded with it
Click to expand...

I think Yellow Gold is pure berberine or close to it but never got the confrimation in this board or at NP or even USPlabs.

If Yellow Gold is not berberine then it would be good to have a bulk pure berberine powder (extracted from plants preferably).
 
Quadzilla99 said:
How much berberine is in yellow gold? Isn't that loaded with it
Click to expand...

Yellow gold is pure berberine. It's great stuff! I have gone through several tubs and it is my favorite bulk GDA product. I can get berberine for about 60 USD per kilo here (from China), but I don't mind paying more because nutra does third party analyses.
 
tyrub42 said:
Yellow gold is pure berberine. It's great stuff! I have gone through several tubs and it is my favorite bulk GDA product. I can get berberine for about 60 USD per kilo here (from China), but I don't mind paying more because nutra does third party analyses.
Click to expand...

Hit me up on FB man think I can help ya out
 
NattyForLife said:
Would burn24 or recompadrol work better when reverse dieting. Im leaning toward the burn24 since while reverse dieting you will still be in a deficit for a couple of weeks until you get up to maintenance?
Click to expand...

Flip a coin. Not sure it would really matter too much in that situation between the two.
 
You must log in or register to reply here.
Back
Top