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2,17α-dimethyl-17β-hydroxy-5α-androst-2-ene

Anabolimac

New member
Very excited about the news of this compound ,upcoming in a new iron legion product.would love to know more about it anything .It seems like it has the potential to be a monstrous gainer surpassing m1t this would be an amazing new supplement love to also know how anyone thinks real world results will play out.
 
It's been out for many many years. It's called methyl sten... or even more widely known to the forum bros as Mass Tabs.
It's not better for 'gains' than M1T.
 
Ehh methylstenbolone is 2,17a-methyl-5a-androsta-1-en-17b-ol-3-one this compound while similar, dons a 17beta hydroxy function and 2-ene bond
It's called dimethandrostenol ,completley different beast this could be considered desoxymethasterone
 
this looks pretty powerful according to vida. 10 times methyltest. I hope they test it to validate it. The stuff could also be referred to as 2-methyl DMT (2-methyl madol)
 
Anabolimac said:
Ehh methylstenbolone is 2,17a-methyl-5a-androsta-1-en-17b-ol-3-one this compound while similar, dons a 17beta hydroxy function and 2-ene bond
It's called dimethandrostenol ,completley different beast this could be considered desoxymethasterone
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****, I missed 3-keto group not being posted... I need to stop reading so late at night and stick to watching stupid videos. Looks interesting though.

I think there's a protocol where you can burn down a ketone to an alkene; makes me wonder if you can make it from SD if you can get the elimination to happen at the more substituted side.
 
Beejis60 said:
****, I missed 3-keto group not being posted... I need to stop reading so late at night and stick to watching stupid videos. Looks interesting though.

I think there's a protocol where you can burn down a ketone to an alkene; makes me wonder if you can make it from SD if you can get the elimination to happen at the more substituted side.
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you would need to protect the 17b-OH as a ketal or something. then reduce C3 to OH. then p-toluenesulfonylchloride to make pTSA ester. Then boil in collidine and you will have your 2 ene. The workup of the collidine reaction mix is often done with sulfuric acid so that may deprotect 17bOH
 
Patrick Arnold said:
this looks pretty powerful according to vida. 10 times methyltest. I hope they test it to validate it. The stuff could also be referred to as 2-methyl DMT (2-methyl madol)
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Methyl DMT holy ****ing ****
 
Patrick Arnold said:
you would need to protect the 17b-OH as a ketal or something. then reduce C3 to OH. then p-toluenesulfonylchloride to make pTSA ester. Then boil in collidine and you will have your 2 ene. The workup of the collidine reaction mix is often done with sulfuric acid so that may deprotect 17bOH
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Wut? Isn't collidine too sterically hindered to eliminate from the 2-position due to the methyl group there? I would think it would rather eliminate from the 4-position giving an a,b unsaturation. But I meant like a one step procedure. I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.
 
Original DMT Was shown in a study to enlarge the heart. Strong possibility this may have an even stronger effect on the heart?
 
Duywayne said:
Original DMT Was shown in a study to enlarge the heart. Strong possibility this may have an even stronger effect on the heart?
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Original DMT was icing dudes... I don't know if I'd go after this white buffalo...
 
Beejis60 said:
Wut? Isn't collidine too sterically hindered to eliminate from the 2-position due to the methyl group there? I would think it would rather eliminate from the 4-position giving an a,b unsaturation. But I meant like a one step procedure. I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.
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i dont think you can directly remove a ketone without it going through an OH

i cant answer your question about the collidine but i picture the mechanism with the collidine coming from the other side, so a 2a-methyl would in fact encourage formation of 2-ene (plus it would be the thermodynamically favored product)
 
Patrick Arnold said:
i dont think you can directly remove a ketone without it going through an OHi cant answer your question about the collidine but i picture the mechanism with the collidine coming from the other side, so a 2a-methyl would in fact encourage formation of 2-ene (plus it would be the thermodynamically favored product)
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The reaction I was talking about is kinda like a tandem Wolff-Kishner/Sn2' reaction.
 
Patrick Arnold said:
not sure what u are referring to
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reed below

Beejis60 said:
I know you can also make a hydrazone, hit it with TEA and I2 and that will give you a vinyl iodide, but not sure of the direction of elimination there either. Then you can sprinkle in a little zinc dust with acetic acid and boom, done.
Click to expand...
 
Kinggrommet said:
You two make me miss organic chem so bad. I need to freshen up on my nomenclature and rxn mechanisms. Fascinating stuff.
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Superdrol + Zn + TMSCl at room temp OR make the tosyl hydrazone, then subject to LiH in refluxing toluene yields the title compound. Both are high-yielding procedures.
 
Beejis60 said:
Superdrol + Zn + TMSCl at room temp OR make the tosyl hydrazone, then subject to LiH in refluxing toluene yields the title compound. Both are high-yielding procedures.
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I dont know the mechanism but would this affect the 17b-OH group?
 
Patrick Arnold said:
I dont know the mechanism but would this affect the 17b-OH group?
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Nope. Only 3-oxo selective. The one paper has 6, 7, and 20-oxo diones and only the 3-keto group is removed.
TMS coordination to carbonyl O, Zn oxidative addition to carbonyl C, reduction to Zn carbenoid, pinacol-type rearrangement... or like a 1,2-hydride shift.
 
Beejis60 said:
Nope. Only 3-oxo selective. The one paper has 6, 7, and 20-oxo diones and only the 3-keto group is removed.
TMS coordination to carbonyl O, Zn oxidative addition to carbonyl C, reduction to Zn carbenoid, pinacol-type rearrangement... or like a 1,2-hydride shift.
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cool

please email me the paper thanks
 
Patrick Arnold said:
coolplease email me the paper thanks
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They're two early 70s and mid 70s RSC papers, so no mechanism published though they discuss it. Yields kinda suck actually; the book I found it in though, Comprehensive Org. Synthesis said 95%... spoke too soon. The tosylhydrazone reaction is better; I've never made tosylhydrazones but free hydrazones and azines preps are balls simple and high-yielding, and the following LiH redox protocol is mid 90% yields.
 
while the compound looks interesting, I just would like to know, what level of schooling would I need to be, in order to be up to par with you guys?
 
Patrick Arnold said:
years of graduate school and years of experience in the lab
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well, I'm currently about to start my Labtech program and will have a medical lab tech certification and BA in applied science. That said I haven't worked in a lab so not really sure what to except as far a a learning curve. I suspect though I would like to get into research field at some point.
 
tilldeath said:
well, I'm currently about to start my Labtech program and will have a medical lab tech certification and BA in applied science. That said I haven't worked in a lab so not really sure what to except as far a a learning curve. I suspect though I would like to get into research field at some point.
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a medical lab is not a chemistry lab. and you wont be doing chemical synthesis.

u will learn stuff but you wont learn the stuff we are talking about. but why do u want to know chemical synthesis anyway? to sound cool?
 
tilldeath said:
well, I'm currently about to start my Labtech program and will have a medical lab tech certification and BA in applied science. That said I haven't worked in a lab so not really sure what to except as far a a learning curve. I suspect though I would like to get into research field at some point.
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not the mama


You need a certain amount of knowledge and "mojo" as some people call it. I'm a few months from my Ph.D. in synthetic organic chemistry, so I deal with reactions and mechanisms all day. Two problem sessions a week, daily reading, two group meetings, etc. It's very tedious and you'll never be an amazing chemist, no offense, but if it helps don't consider myself amazing by any means either. Pat also went to grad school for the same awhile ago. I can't remember if he mastered out or just left, but I think he ended up in NJ, yes? Eventually settled with what he currently does, which is probably a bit more than one would realize. Just undergrad organic will not help with anything and steroid synthesis is kind of a niche corner of organic chemistry, most of it being developed through the 70s it seemed. Still some people do it, but not a ton... it's like carbohydrate chemistry. Kinda boring and old.

Patrick Arnold said:
a medical lab is not a chemistry lab. and you wont be doing chemical synthesis.

u will learn stuff but you wont learn the stuff we are talking about. but why do u want to know chemical synthesis anyway? to sound cool?
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This. It's not that glamorous as you may think it is. It's tedious and ridiculous, honestly. I've been effing around with the same system the past 2-3 years and I'm sick of it. I can't wait till it's over. It's mostly hard work and often repetitive.
 
Patrick Arnold said:
a medical lab is not a chemistry lab. and you wont be doing chemical synthesis.

u will learn stuff but you wont learn the stuff we are talking about. but why do u want to know chemical synthesis anyway? to sound cool?
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For me it's nothing more than a hobby more than likely, but I find it very interesting. The only thing I have ever messed with is extracting DMT via acid/base extraction. That kind of spraked it and the world of PH's and chemical bonds I find interesting. I may if nothing else just take Oganic chem and a few other courses in my spare time to gain some knowledge.
 
Beejis60 said:
not the mamaYou need a certain amount of knowledge and "mojo" as some people call it. I'm a few months from my Ph.D. in synthetic organic chemistry, so I deal with reactions and mechanisms all day. Two problem sessions a week, daily reading, two group meetings, etc. It's very tedious and you'll never be an amazing chemist, no offense, but if it helps don't consider myself amazing by any means either. Pat also went to grad school for the same awhile ago. I can't remember if he mastered out or just left, but I think he ended up in NJ, yes? Eventually settled with what he currently does, which is probably a bit more than one would realize. Just undergrad organic will not help with anything and steroid synthesis is kind of a niche corner of organic chemistry, most of it being developed through the 70s it seemed. Still some people do it, but not a ton... it's like carbohydrate chemistry. Kinda boring and old.This. It's not that glamorous as you may think it is. It's tedious and ridiculous, honestly. I've been effing around with the same system the past 2-3 years and I'm sick of it. I can't wait till it's over. It's mostly hard work and often repetitive.
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you are doing reactions that are far more complex than anything i could get into for practical reasons, because anything I am going to make has to be economical and done on a scale which is impractical for techniques such as chromatographic purification. I need high yield and reagents which are not too expensive and toxic. When i look at a synthesis i can immediately tell if its something that has a possibility to be scaled up and 9 times out of 10 its not
 
tilldeath said:
For me it's nothing more than a hobby more than likely, but I find it very interesting. The only thing I have ever messed with is extracting DMT via acid/base extraction. That kind of spraked it and the world of PH's and chemical bonds I find interesting. I may if nothing else just take Oganic chem and a few other courses in my spare time to gain some knowledge.
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thats not even synthesis. its just a little more complicated than making coffee
 
exactly, that's why I said it was an extract. I looked into synthesizing DMT, but seems a bit over my head and I really don't want to risk anything I would be taking. Off topic and feel free to PM, but any advice on best ways to obtain DMT? Sources for extract have fallen off and while not illegal or impossible to get are difficult to source. Anyways thanks for the info, like I said more curious than anything and always looking for ways to expand my knowledge base.
 
tilldeath said:
exactly, that's why I said it was an extract. I looked into synthesizing DMT, but seems a bit over my head and I really don't want to risk anything I would be taking. Off topic and feel free to PM, but any advice on best ways to obtain DMT? Sources for extract have fallen off and while not illegal or impossible to get are difficult to source. Anyways thanks for the info, like I said more curious than anything and always looking for ways to expand my knowledge base.
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try bluelight.ru or something this is not the place for that discussion
 
Patrick Arnold said:
you are doing reactions that are far more complex than anything i could get into for practical reasons, because anything I am going to make has to be economical and done on a scale which is impractical for techniques such as chromatographic purification. I need high yield and reagents which are not too expensive and toxic. When i look at a synthesis i can immediately tell if its something that has a possibility to be scaled up and 9 times out of 10 its not
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Aware ;)
 
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