versa 1 semi fasted
- Thread starter R1balla
- Start date
breezy11
Well-known member
In my experience, it usually does. The effect varies for me quite a bit, which might have something to do with what and when I've eaten prior.
Agent Orange
Member
As soon as mine comes in I'm going to try fasted cardio with it. I love getting a good sweat first thing in the morning.
Distilled Water
Board Sponsor
The increased thermo response?
Distilled Water
Board Sponsor
I dosed fasted on non-workout days. Never noticed anything too crazy in that department but I'm usually a sweaty mess so I'm not the ideal person to ask.
Guess I'm saying, just bc you don't "feel" it, doesn't mean it isn't working.
USPlabsRep
Board Sponsor
Lipolysis is blunted by carbohydrates consumption (well Insulin release)...
it makes sense...
mr.cooper69
Legend
More specifically, AMP is high in a fasted state. and thermogenesis via the last step in oxidative phosphorylation is stimulated by an increase in AMP/fall in ATP at the level of phosphofructokinase-1. This same step is also stimulated by glucagon/epinephrine and inhibited by insulin vicariously through fructose-6-phosphate/fructose-2,6-bisphosphate.
jswain34
Well-known member
Yah. How more fasted=more thermo response. I understand the whole insulin/lipolysis situation. But lipolysis always correlate with sweating, does it?
strategicmove
Legend
Sure does. The greater the expression of macronutrients during exercise, the greater the inhibition of intra-exercise fat oxidation. In other words, in non-fasted training states, hormone sensitive lipase (HSL) activity is blunted, as intramyocellular triacylglycerol (IMTG) recruitment as an energy substrate during exercise is highly expressed during fasted, but not non-fasted, states.
In particular, intra-exercise degradation of IMTGs - [IMTGs are, by the way, accumulated as lipid droplets in skeletal-muscle cytoplasm in the vicinity of the mitochondria, the site for free fatty acid metabolism and release via hydrolysis] - is mediated by the enzyme HSL, a cyclic-AMP-mediated neutral triacylglycerol lipase that cleaves the first and second fatty acids from the glycerol backbone and constitutes the rate-limiting step in lipolysis/IMTG hydrolysis [as it cleaves fatty acids and is regulated by intramuscular (contraction) and extra-muscular (epinephrine) factors]. More specifically, in this initial step, the hormonal activation of adenylate cyclase triggers elevated cyclic AMP and cyclic-AMP-dependent protein kinase activity, stimulating the downstream phosphorylation and activation of HSL. Fatty acids released from IMTGs into the cytoplasm are transported to the outer mitochondrial membrane. In the outer mitochondrial membrane, these fatty acids are enzymatically converted to fatty acid carnitine via binding with CoA, are channeled across the mitochondrial membranes to be metabolized in the beta-oxidation pathway in the mitochondria, generating NADH, FADH2, and acetyl-CoA [ultimately metabolized in the tricarboxylic pathway to synthesize ATP via oxidative phosphorylation].
Distilled Water
Board Sponsor
To an extent. The absence in insulin amplifies the affects of almost everything. In some simple terms, whether it be your coffee black vs. cream & sugar. Alcohol on the rocks vs. a jack & coke (regular not diet) you feel the affects faster & "harder" when there's no insulin.
Add the fact you're coming from a faster state and its more intense. I notice the affects of coffee like its crack when I'm on a pure keto. One cup gets me running around at hyper speed.