Higenamine/Norcoclaurine [NATTYDISASTER, PLEASE TAKE A LOOK :D]

menphisdaemon

menphisdaemon

New member
Hi bros, i was lookin' at the new alpha T2 by PES...great stuff as usual, i am really impressed by this formula. When I found higenamine i made some research and i found it is a beta agonist (looking at the instruction, i suppose a short term beta agonist). I was just wondering if it is a selective or non selective beta agonist...

Thanks
 
If you want selective, buy clenbuterol/albuterol.

But as he said, most are like firing a shotgun. Everyone gets hit and on occasion one gets hit harder than the rest. Since it does have such a short half life, and you likely wont be running it for longer than a bottle (cycle). You need not really worry about your beta receptors as they do slightly recover over periods of time. With a low carb diet,
*remember time on cycle = time off*

Keep your diet in check, make sure to deplete glycogen stores, sleep, and have fun getting shredded. ;)
 
Hi man!, thanks as usual for the kind reply! Ok, so let's say it's something that acts like (of course i suppose a lot less potent) clen? In my opinion it's fat-killing stack combining a b-agonist and an a-antagonist like rawalscine.

Just to give me an idea...can you tell me how much potent is higenamine?

P.S. My friend (remember the email?) got in touch with predator for a little product try...maybe in the future you will have a deal ;)
 
oogaly_boogal said:
If you want selective, buy clenbuterol/albuterol.

But as he said, most are like firing a shotgun. Everyone gets hit and on occasion one gets hit harder than the rest. Since it does have such a short half life, and you likely wont be running it for longer than a bottle (cycle). You need not really worry about your beta receptors as they do slightly recover over periods of time. With a low carb diet,
*remember time on cycle = time off*

Keep your diet in check, make sure to deplete glycogen stores, sleep, and have fun getting shredded. ;)
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Ahaha, thanx man...believe me, I'm quiete sure of what i do in dieting,training etc. LOL ;)

Thank you for the reply but my question was specific...and natty perfectly answer at that.
 
oogaly_boogal said:
If you want selective, buy clenbuterol/albuterol.

But as he said, most are like firing a shotgun. Everyone gets hit and on occasion one gets hit harder than the rest. Since it does have such a short half life, and you likely wont be running it for longer than a bottle (cycle). You need not really worry about your beta receptors as they do slightly recover over periods of time. With a low carb diet,
*remember time on cycle = time off*

Keep your diet in check, make sure to deplete glycogen stores, sleep, and have fun getting shredded. ;)
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Yup. The reason things like clen can be taken for only 2 weeks are due to high selectivity and longer half life. But things like ephedrine can be taken longer because they are non selective and shorter half life, as the case with higenamine
 
menphisdaemon said:
Hi man!, thanks as usual for the kind reply! Ok, so let's say it's something that acts like (of course i suppose a lot less potent) clen? In my opinion it's fat-killing stack combining a b-agonist and an a-antagonist like rawalscine.

Just to give me an idea...can you tell me how much potent is higenamine?

P.S. My friend (remember the email?) got in touch with predator for a little product try...maybe in the future you will have a deal ;)
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Rauwolscine causes alpha-2 antagonism, a very special method to fat loss. This turns OFF fat STORING receptors. So not only do you turn off fat storing pathways, you upregulate fat loss pathways.

Now that these receptors are turned off, fat loss can further occur via beta pathways. That is why we went with a beta-agonist, Higenamine.

Extreme fat loss synergy.
 
nattydisaster said:
Rauwolscine causes alpha-2 antagonism, a very special method to fat loss. This turns OFF fat STORING receptors. So not only do you turn off fat storing pathways, you upregulate fat loss pathways.

Now that these receptors are turned off, fat loss can further occur via beta pathways. That is why we went with a beta-agonist, Higenamine.

Extreme fat loss synergy.
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Have yet to find indefinite answers to this, but since rauwolscine is alpha-yohimbine, would it produce negative sides when coupled with saaaaay a 2 hour workout?

sorry to hijack Invalid Link Removed by the way
 
oogaly_boogal said:
Have yet to find indefinite answers to this, but since rauwolscine is alpha-yohimbine, would it produce negative sides when coupled with saaaaay a 2 hour workout?

sorry to hijack Invalid Link Removed by the way
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I imagine many people have been doing workouts in that range when on fat loss routines and taking Alpha-T2
 
I do and no negative sides to report. Natty, not to hijack this thread, but how would you dose the new alpha t2 with something like Dexaprine?
 
Thanks one more time! GREAT stuff as I said before.
I just wanted, if possible, a misure of the potence of higenamine. Let's say..if you put clen 6 on a 0-10 scale, where would you put higenamine? I know it's a stupid question but it's just to give me an idea...
 
southpaw23 said:
I do and no negative sides to report. Natty, not to hijack this thread, but how would you dose the new alpha t2 with something like Dexaprine?
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Hard to judge since it is a prop blend...but personally I would just do a half tablet of it in the morning. The stack with OEP will be more synergistic with AT2 than anything else...like the old formula just better
 
nattydisaster said:
Hard to judge since it is a prop blend...but personally I would just do a half tablet of it in the morning. The stack with OEP will be more synergistic with AT2 than anything else...like the old formula just better
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What was the reasoning for removing the methyl-synephrine? Could you have kept the original formula and added the 40mg's of Hingenamine?
 
Rucksdaddy said:
What was the reasoning for removing the methyl-synephrine? Could you have kept the original formula and added the 40mg's of Hingenamine?
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Id assume it would be one of these three reasons:
1. expensive to make = expensive for the consumer
2. two strong beta-adrenergic agonist would be dangerous.
3. more isn't always better when it comes to fat loss.
 
oogaly_boogal said:
Id assume it would be one of these three reasons:
1. expensive to make = expensive for the consumer
2. two strong beta-adrenergic agonist would be dangerous.
3. more isn't always better when it comes to fat loss.
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I assumed #2, but wasn't sure if they worked on different pathways. Price doesn't bother me if the effects are there (without the sides of course).
 
Rucksdaddy said:
What was the reasoning for removing the methyl-synephrine? Could you have kept the original formula and added the 40mg's of Hingenamine?
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I dont like the idea of mixing beta agonists

oogaly_boogal said:
Id assume it would be one of these three reasons:
1. expensive to make = expensive for the consumer
2. two strong beta-adrenergic agonist would be dangerous.
3. more isn't always better when it comes to fat loss.
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1. Higenamine is actually more expensive than MS, but even so we are not increasing the price to our loyal customers.

2. correct

3. correct. We are focused on synergy, not just fat loss ****tail blends

mr.cooper69 said:
MS wasnt DSHEA compliant. but it was better than higenamine :(
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Was not aware you have used both in their pure form...when did this occur?
 
PES is probably getting for synephedrine to be pulled from the market too. Nothing wrong with that, so no offence :)
 
nattydisaster said:
Was not aware you have used both in their pure form...when did this occur?
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I haven't, but I have reviewed the science. I really like MS btw.

That said, I'm considering never saying anything about an ingredient used by PES again on these boards. Stop being so sensitive.
 
Higenamine is by far the cleanest beta agonist I have ever used, with equal or greater effects on thermogenesis than MS. Plenty of others will soon agree. Does not last as long as MS, which is a plus to us.

It is different than MS, not inferior. It fits the AT2 formula better coupled with the synergy of alpha-yonhimbine's alpha-2 antagonistic properties and shows that same property itself, which I have never seen in MS.

Like comparing clen to ephedrine to albuterol...all very different...one person will tell you one is better for one reason or another, another person will say a different one was better.

We love MS, no doubt, and the research behind it is undeniable. Thats why we have been using it for over a year. But after we tested with Higenamine we liked the formula better. We have spent a lot of time testing it, as you can see how old some of the beta feedback is: Invalid Link Removed
 
nattydisaster said:
Higenamine is by far the cleanest beta agonist I have ever used, with equal or greater effects on thermogenesis than MS. Plenty of others will soon agree. Does not last as long as MS, which is a plus to us.

It is different than MS, not inferior. It fits the AT2 formula better coupled with the synergy of alpha-yonhimbine's alpha-2 antagonistic properties and shows that same property itself, which I have never seen in MS.

Like comparing clen to ephedrine to albuterol...all very different...one person will tell you one is better for one reason or another, another person will say a different one was better.

We love MS, no doubt, and the research behind it is undeniable. Thats why we have been using it for over a year. But after we tested with Higenamine we liked the formula better. We have spent a lot of time testing it, as you can see how old some of the beta feedback is: Invalid Link Removed
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i was one of the 1st users of the original, and have used many, many bottles of it.

after only 2 days, i can say that the new formula has the potential to be much better.

i think you did a fine job natty, and so far i am very happy with the change.
 
stupid question is stupid; BUT how would this pair with ephedrine? I am quite tolerant to Ephedrine, I take naps on it and can fall asleep after taking it, I really want to try out alpha-t2.
 
DaveGabe24 said:
This post just screams burnt out adrenals to me.
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Yeah, I thought so too but I had taken 3 weeks off of EC, which before I ran for 4 weeks (yes off = on cycle i know); but at the end of the 4 weeks i still felt the ec more than I do on this cycle.

Im fine on other uppers, just ephedrine at 25mg and caffeine at 200mg does nothing for me.

methyl syneprhine still gets me going, rockstar still gets me going, etc. Just something about the EC stack does nothing except burn fat for me now. I mean hell the other day i was doing cardio while on EC (3 hours before) and jack3d (40 min before) @ 15 degrees 4mph, which usually has my heart rate at around 180, it was at 130. I had to hyperventilate just to get it up to 180.
 
took 2 caps of new at2 on a empty 30 minutes before i did 45 minutes on my treadmill. the sweat could be measured in bucket fulls. my body felt very warm!!!
 
nattydisaster said:
Sounds like when I take it!

Glad your caffeine free weekend was still full of sweat lol
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i cheated a little, lol. but way below my normal intake. i think next weekend i will just stick with at2 and no caffeine!!!
 
mr.cooper69 said:
I haven't, but I have reviewed the science. I really like MS btw.

That said, I'm considering never saying anything about an ingredient used by PES again on these boards. Stop being so sensitive.
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As everyone said prior, if you are going to make a statement, just back it up with some opinion or information. It helps no one just saying this is better or that. Say whatever the hell you want, but at least say why.
 
nattydisaster said:
Sounds like when I take it!

Glad your caffeine free weekend was still full of sweat lol
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Im starting to think I have really bad adrenal fatigue hahaha. How would at2 be for me? I know its a beta agonist but would it affect my adrenal glands? If so I have some clen on hand until they return to normal.
 
oogaly_boogal said:
Im starting to think I have really bad adrenal fatigue hahaha. How would at2 be for me? I know its a beta agonist but would it affect my adrenal glands? If so I have some clen on hand until they return to normal.
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A beta agonist would not help adrenal fatigue lol. If you do suspect you have some acute adrenal fatigue, try something like Revamp. Same formula as the old Reset AD
 
Thanks, just ordered a bottle. I don't have all the symptoms, just tired all day. I don't have issues while working out and the such.
 
I've used both versions of Alpha-T2, actually I started the newest version 2 days ago, took it as a preworkout aid and I was sweating more than I normally do with the first version, and by that I mean the first version had me drenched. THIS ONE IS BETTER.
 
nattydisaster said:
A beta agonist would not help adrenal fatigue lol. If you do suspect you have some acute adrenal fatigue, try something like Revamp. Same formula as the old Reset AD
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That's great to know. Before I recommended AOR Adrenal, I actually looked for the Reset-AD quick. I had never heard of Revamp. Definitely a good idea for people running stims for long periods, and want to have some damage control for the withdrawals :p
 
Effects on Dopamine

At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

Invalid Link Removed

Any concerns for depression on this stuff? :(

Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
 
Whacked said:
Effects on Dopamine

At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

Invalid Link Removed

Any concerns for depression on this stuff? :(

Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
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Im on my off cycle of enhanced and i can say i felt depressed for 2 weeks and couldnt wait to get back on until I took focus xt.
 
Higenamine does not cross over into the CNS where neuronal cells are located. Therefore, it is physiologically impossible for it to cause depression unless injected directly into your brain
 
Whacked said:
Effects on Dopamine

At a concentration of 20mM, Higenamine has been shown in vitro to deplete dopamine concentrations in PC12 neuronal cells by 55.2% with an IC50 of 18.2mM;[16] this was thought to be through inhibition of tyrosine hydroxylase, which converts L-DOPA into dopamine.[17]

Invalid Link Removed

Any concerns for depression on this stuff? :(

Depression is one of the most common problems associated with low dopamine levels. Fatigue, a loss of interest in previously enjoyed activities, and an inability to focus are common symptoms of depression. Drug and alcohol addiction sometimes develops as a coping mechanism for depression as the affected person searches for ways to feel better, even if only for a short period of time. The weight gain associated with low dopamine levels may be related to emotional eating in many cases.
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What should be bolded in the abstract is a concentration OF 20 MILLIMOLAR. So not only would you need to inject higenamine, but you'd need to inject a metric ton.
 
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