Formestane

I realize this study is for oral formestane and post-menopausal breast cancer patients (obviously women :D), but here is a study that shows 15% drop in SHBG at 250mg orally:

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So I guess if one was to simply drop formestane without tapering, wouldn't there be more available estrogen to act on breast/hypothalamus? Just speculating, but I've spent a lot of time thinking about the causes of "rebound gyno" after a SD cycle, and I speculate that SHBG plays a very large role in this phenomenon.
 
diablosho said:
I realize this study is for oral formestane and post-menopausal breast cancer patients (obviously women :D), but here is a study that shows 15% drop in SHBG at 250mg orally:

Invalid Link Removed

So I guess if one was to simply drop formestane without tapering, wouldn't there be more available estrogen to act on breast/hypothalamus? Just speculating, but I've spent a lot of time thinking about the causes of "rebound gyno" after a SD cycle, and I speculate that SHBG plays a very large role in this phenomenon.
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SHBG has a stronger affinity for testosterone and DHT over estrogen. So lowering or raising SHBG will have a way greater affect on T & DHT over E. Lowering SHBG will raise free testosterone which is key to muscle building and muscle preserving post cycle. It is a good thing Formestane lowers SHBG.

I think a SERM has something to do with rebound gyno. Superdrol will have an extremely potent effect on estrogen suppression so coming off that and jumping into Nolvadex which will raise estrogen and make you more sensitive to estrogen post-SERM which warrants the correct use of an AI when you are ready to come off the SERM. Correct use of AI and SERM should be used to fully avoid rebound issues. Not one or the other.

And I agree, tapering off an AI is always best if you are taking a higher dose.
 
To add to that, if rebound gyno isn't estrogen related, it will be prolactin related. Another good reason to use Formestane post-SERM or a low dose during PCT of a Superdrol cycle is it lowers prolactin.

Superdrol has no affinity to 5ar in the nuclear membrane even though it is related to DHT. It's metabolites just circulate the blood stream incapable of binding to estrogen receptors because it cannot aromatize and it also can't bind to androgen receptors. Circulating androgens of SD can use prolactin as transport molecules to the nucleus. This can cause the body to increase amounts of prolactin so androgens may reach the nucleus. Elevated prolactin levels can enlarge breasts and cause puffy and leaking nipples which can lead to good ol' gyno.

I think the best way to prevent any kind of Superdrol gyno is to use a SERM for PCT and start Forma-stanzol a few days to a week before coming off the SERM. You can become sensitive to estrogen post-SERM and also have high estrogen due to using a SERM, but Formestane will lower estrogen and lower prolactin which can stay elevated months after Superdrol.
 
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