? about letro.

Justing2

Member
Im going to be using Letro for the 1st time to clear up some gyno I got from a cycle about 3 months ago and I had just a couple of ?'s
1 when is the best time to take it? I work out at 4am, should I take it before I work out.
2 is it still possible to gain muscle well on Letro?
Thanks a lot for the help.
 
Take it all before bed...those things have extremely long half-lives...someone correct me if I'm wrong but I think they're all at least 18 hrs or so...you can find letro's on wiki really easily but I'm not going to do THAT for you ha just messin....I vote b4 bed
 
yes you can gain muscle on letro but I wouldn't go for strength so much your joints will ache really easily...high volume, cutting up type stuff
 
Thanks! I know that Im suppose to go into it slowly and reduce it slowly but I just wasn't sure when is the best time to take it.
Thanks again.
 
You will loose water weight, and wont be able to hold any while on letro... You will have muscle hardening effects, and look more ripped.. Letro can make you feel like **** at even a moderate dose, trust me, I know... If you want to cure your gyno, your gonna have to stick with it, even though you will want to stop taking it...
 
Ok thanks!! Just one last real stupid question? I know that the dropper filled is 2.5mg's. Is that filled to the top? I know real bad ?
 
Justing2 said:
Ok thanks!! Just one last real stupid question? I know that the dropper filled is 2.5mg's. Is that filled to the top? I know real bad ?
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The dropper should have a fill line. If it doesnt the bottle should have a dosage, e.g. 2.5mg/ml. Get a syringe and measure that way. Especially since you aren't taking 2.5mgs. What are you going to estimate it being 40% full for 1mg?
 
Its 2.5/30 and the email I got from the company was 1ml equals 2.5mg's but the dropper that came with it dosent have any markings on it and I know you shouldn't start with the full dose or should I?
 
Justing2 said:
How bad is it if you just start with 2.5mg's?
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Bad. You need to titrate your dosage appropriately. The dosing is 2.5mg/30mL? That can't be true. That's 83 micrograms per mL. Check again. You'll need a syringe either way.
 
He means 2.5mg/mL and 30mL vial.

Start at 1.25mg (1/2 mL) and adjust from there

We leave it in your capable hands to figure out how to measure half a mL
 
Yeah Im a bone head I told you guys the reading backwards.
I just took about 1/2 a serving. Doesn't seem like much at all.
 
indianballer said:
yes you can gain muscle on letro but I wouldn't go for strength so much your joints will ache really easily...high volume, cutting up type stuff
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Side Note: High repetitions isn't the way to get 'cut' or 'tone'. That's one of the worst gym myths ever.

(Although, I do agree with not trying to set 1-3 rep maxes when joint problems are an issue.)

Ok, back to the thread.
 
Im on day like day 11 of letro.. I went right into 2.5mg/day without tapering up.
My joints have started to get sore and Im just recently starting too see very minimal decrease in size of the gyno tissue.

Libido has dropped a little.. but nothing bad like it did when I was shutdown from superdrol. I have my Cialis just incase it goes to **** though, haha.
 
Today I did about 1mg's and tomorrow I will bump it up to about 1.25 and take it from there. Is there any truth to holding it under your tongue for 15sec? Does it matter if you take it with food or not?
 
Justing2 said:
Today I did about 1mg's and tomorrow I will bump it up to about 1.25 and take it from there. Is there any truth to holding it under your tongue for 15sec? Does it matter if you take it with food or not?
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It works best if you take it with a suppository (joke).

But seriously, whether you take it with food or not doesn't really matter: Invalid Link Removed
...the rate of letrozole absorption decreased slightly under fed conditions. However, in view of the half-life of about 2 d this small change in the absorption rate is not considered to be of clinical relevance for treatment with repeated administrations.
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Never heard of the tongue thing.
 
Libertarian said:
It works best if you take it with a suppository (joke).

But seriously, whether you take it with food or not doesn't really matter: Invalid Link Removed

Never heard of the tongue thing.
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The Wiley InterScience link didn't work. Can you post the citation?
 
CrazyChemist said:
The Wiley InterScience link didn't work. Can you post the citation?
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I'll do you one better.... Citation AND abstract! Which is all you need since most of us never venture past the abstract anyhow ;).

COMPARATIVE BIOAVAILABILITY OF LETROZOLE UNDER FED AND FASTING CONDITIONS IN 12 HEALTHY SUBJECTS AFTER A 2·5*MG SINGLE ORAL ADMINISTRATION

SO: Biopharmaceutics & Drug Disposition
VL: 18
NO: 6
PG: 489-497
YR: 1997
CP: Copyright © 1997 John Wiley & Sons, Ltd.
ON: 1099-081X
PN: 0142-2782

AD: Laboratoires Ciba-Geigy, Bioanalytics and Pharmacokinetics, Medical Department, B.*P. 308, 92506 Rueil-Malmaison, France; Ciba-Geigy Limited, Human Pharmacology, Bioanalytics and Pharmacokinetics, Biometrics, CH-4002, Basle, Switzerland
DOI: 10.1002/(SICI)1099-081X(199708)18:6<489::AID-BDD36>3.0.CO;2-P
US: http://dx.doi.org/10.1002/(SICI)1099-081X(199708)18:6<489::AID-BDD36>3.0.CO;2-P

AB: Letrozole is a new non-steroidal inhibitor of the aromatase enzyme system. It is currently under development for the treatment of postmenopausal women with advanced breast cancer. To investigate the influence of food on the bioavailability of letrozole, 12 healthy male volunteers were treated under fed and fasted conditions with single oral doses of 2·5*mg letrozole in film-coated tablets. Plasma concentration profiles were determined. No significant difference in the extent of absorption (AUC or AUC0-8*h) was observed between the two treatments but the rate of letrozole absorption decreased slightly under fed conditions. However, in view of the half-life of about 2*d this small change in the absorption rate is not considered to be of clinical relevance for treatment with repeated administrations. © 1997 John Wiley & Sons, Ltd.
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Libertarian said:
Side Note: High repetitions isn't the way to get 'cut' or 'tone'. That's one of the worst gym myths ever.

(Although, I do agree with not trying to set 1-3 rep maxes when joint problems are an issue.)

Ok, back to the thread.
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I hate you. You got completely off topic for no reason. Trust me I know how to get big with diet and I know how to get cut with diet. Your post had nothing to do with letro. I said stay away from strength type stuff on letro.

Now go kill yourself.
 
indianballer said:
I hate you. You got completely off topic for no reason. Trust me I know how to get big with diet and I know how to get cut with diet. Your post had nothing to do with letro. I said stay away from strength type stuff on letro.

Now go kill yourself.
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Sensitive much?

You must be in PCT.

Oh, and squashing bro-lore is always a good reason to divert slightly off-topic. There is a lot of that crap around here.

Now, back to the topic (if indianballer is done whining, that is)...
 
So Im about 5 days into the Letro and I noticed that today my nipples started to hurt a little like they did when the Gyno started. Is this normal?
Thanks
 
Justing2 said:
So Im about 5 days into the Letro and I noticed that today my nipples started to hurt a little like they did when the Gyno started. Is this normal?
Thanks
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Hmm I never have gyno so IDK. If you have gyno you might want to go under the care of a physician.
 
Well on tuesday it will be a week now that I have been on Letro and I know its early but so far no sides and Im at the full dose. Just wondering from people that have used this before to get ride of gyno(superdrol induced) when do you start to see and feel the results?
 
Just wanted to bump this. Im wondering when people start see results when using Letro. Ive been on it about a week and a half and I think its getting smaller but its really hard to tell.
Thanks
 
I just talked to a guy and he's been at 2.5 for about 20 days and he said he's just now starting to see slight results. How have the sideeffects been, as harsh as everyone says?
 
Justing2 said:
So Im about 5 days into the Letro and I noticed that today my nipples started to hurt a little like they did when the Gyno started. Is this normal?
Thanks
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Anytime there is a change in hormones the nipples can become puffy, sensitive and discolored. Nothign to worry about unless you started right at 2.5mg. If you did you are probably gonna have problems
 
I can tell u I pm'd the guy a while back n he said he ditched the cycle and ran epi.. it apparently worked. I don't suggest his method. Keep searching, you'll find the success of this method.
 
letro's the worst, what are you taking it for?

ugh, only thing worse than letro is clomid... letro made me irritable and restless as **** although it has a few uses

such as trying to recover from VERY heavy cycles, as a part of a drug regimen to reduce gyno, or for anti-bloat effects for COMPETITION ONLY.

otherwise there are far better alternatives like exemestane and anastrozole.
 
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