letrozole versus clomid

CrazyChemist

CrazyChemist

Well-known member
Does letrozole essentially have the same effect as clomid? Is there ever a reason to take one over the other?
 
No, They aren't the same.

Clomid is SERM (Selective Estrogen Receptor Modulator) while Letro is non-steroidal Aromatase Inhibitors (Type II).

Clomid acts as weak estrogen and binds at estrogen receptor, it inhibits the action of estrogen on the hypothalamus. This prevents normal receptor recycling and causes an effective reduction in hypothalamic estrogen receptor number. Since estrogen can no longer effectively feedback on the hypothalamus, GnRH secretion becomes more pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release.

Letrozole works by inhibiting the action of the enzyme aromatase. Aromatase is an enzyme that synthesizes estrogen, which converts androgens into estrogens by a process called aromatization.
Therefore, Aromatase inhibitors block the synthesis of estrogen.
Non-Steroidal (Type II) AI inhibit the enzyme by reversible competition.

You couldn't take one over the other.

Letro is best used for gyno.
Clomid is best used to stimulate HPTA.

For PCT, I recommend using SERM + AI (after the SERM use) + Cortisol Control + Natural Test Booster.

Hope it helps...
 
Yellow said:
No, They aren't the same.

Clomid is SERM (Selective Estrogen Receptor Modulator) while Letro is non-steroidal Aromatase Inhibitors (Type II).

Clomid acts as weak estrogen and binds at estrogen receptor, it inhibits the action of estrogen on the hypothalamus. This prevents normal receptor recycling and causes an effective reduction in hypothalamic estrogen receptor number. Since estrogen can no longer effectively feedback on the hypothalamus, GnRH secretion becomes more pulsatile, which results in increased pituitary gonadotropin (FSH, LH) release.

Letrozole works by inhibiting the action of the enzyme aromatase. Aromatase is an enzyme that synthesizes estrogen, which converts androgens into estrogens by a process called aromatization.
Therefore, Aromatase inhibitors block the synthesis of estrogen.
Non-Steroidal (Type II) AI inhibit the enzyme by reversible competition.

You couldn't take one over the other.

Letro is best used for gyno.
Clomid is best used to stimulate HPTA.

For PCT, I recommend using SERM + AI (after the SERM use) + Cortisol Control + Natural Test Booster.

Hope it helps...
Click to expand...

Much appreciated that was a perfect response. So if my PCT already includes nolva and clomid for 4 weeks, I should throw in Letro after those four weeks are up? Or is there a better AI to use? Again, :type::thanks:
 
I am not the best in this field, but isnt TOO much AI a bad thing? Every time I see people use letro, tis for on cycle or in response to gyno. Just an opinion, not to be taken as advise.
 
Zero V said:
I am not the best in this field, but isnt TOO much AI a bad thing? Every time I see people use letro, tis for on cycle or in response to gyno. Just an opinion, not to be taken as advise.
Click to expand...

No i heard that too. Its all about balance, not boundless suppression. You do need estrogen for normal body function, just not too much estrogen. I'll have to do more research into this supp.
 
maybe arimidex is better than letro as a preventative AI?? It seems to be the more recommended one.
 
CrazyChemist said:
Much appreciated that was a perfect response. So if my PCT already includes nolva and clomid for 4 weeks, I should throw in Letro after those four weeks are up? Or is there a better AI to use? Again, :type::thanks:
Click to expand...

CrazyChemist said:
maybe arimidex is better than letro as a preventative AI?? It seems to be the more recommended one.
Click to expand...

OK no problem bro.

Yeah, I always take both clomid and nolva for my PCT. It works better than clomid or nolva only.

Aromatase Inhibitors should be started in the last week of your SERM intake or started after finishing SERM.
i.e : take AI week 4-7 or week 5-8

There is no point to start AI in the beginning of PCT because there is no estrogen conversion due to low testosterone level. Your body need to balance the hormonal system first.

In the last week of SERM intake or after finishing SERM, your testosterone is elevated slightly above normal level. This time, estrogen level is usually high also due to the high level of testosterone and due to SERM itself, don't forget that SERM is syntetic estrogen.

By taking AI, you keep the testosterone high while blocking the estrogen conversion.

I think Letro is too strong to be used in PCT.
You had better take low dose arimidex like 0.25mg ED taper down to 0.25mg EOD then 0.25mg E3D.
i.e: 0.25mg/0.25mg/0.25mg EOD/0.25mg E3D/0.25mg twice a week.

You could also take OTC AI like Reversitol, Inhibit-E, 6-OXO, Formadrol, 6-Bromo, Formestane, etc...
Don't forget to taper down also.
i.e : 3caps/3caps/2caps/1caps/1caps EOD
 
Yellow said:
OK no problem bro.

Yeah, I always take both clomid and nolva for my PCT. It works better than clomid or nolva only.

Aromatase Inhibitors should be started in the last week of your SERM intake or started after finishing SERM.
i.e : take AI week 4-7 or week 5-8

There is no point to start AI in the beginning of PCT because there is no estrogen conversion due to low testosterone level. Your body need to balance the hormonal system first.

In the last week of SERM intake or after finishing SERM, your testosterone is elevated slightly above normal level. This time, estrogen level is usually high also due to the high level of testosterone and due to SERM itself, don't forget that SERM is syntetic estrogen.

By taking AI, you keep the testosterone high while blocking the estrogen conversion.

I think Letro is too strong to be used in PCT.
You had better take low dose arimidex like 0.25mg ED taper down to 0.25mg EOD then 0.25mg E3D.
i.e: 0.25mg/0.25mg/0.25mg EOD/0.25mg E3D/0.25mg twice a week.

You could also take OTC AI like Reversitol, Inhibit-E, 6-OXO, Formadrol, 6-Bromo, Formestane, etc...
Don't forget to taper down also.
i.e : 3caps/3caps/2caps/1caps/1caps EOD
Click to expand...

Awesome - thanks!
 
Just a quick clomid question, I ordered about 2 months supply of clomid but half says clomiphene citrate BP and the half is labeled clomiphene citrate IP, whats the diff? I am thinking its because of 2 different manufacturers but not sure.
 
Intellectual said:
Just a quick clomid question, I ordered about 2 months supply of clomid but half says clomiphene citrate BP and the half is labeled clomiphene citrate IP, whats the diff? I am thinking its because of 2 different manufacturers but not sure.
Click to expand...

IP, BP, and USP are the three manufacturers. Its all the same stuff.
 
hey might sound like a dumb question but where is the best place to order clomid, nolva, arimidex, letro, and so on? i have a web site over seas but its always such a hassle? i heard innovative research but i cant figure out if those are all oral or if you have to inject some of them! thanks!
 
lovedaddy said:
hey might sound like a dumb question but where is the best place to order clomid, nolva, arimidex, letro, and so on? i have a web site over seas but its always such a hassle? i heard innovative research but i cant figure out if those are all oral or if you have to inject some of them! thanks!
Click to expand...

Forum rules bro - no posting sources. Sorry dude. Maybe someone will PM you.
 
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