DOSAGE AND ADMINISTRATION
Adults
The initial dose is 20 mg (two NOLVADEX tablets, or one NOLVADEX-D tablet) once daily. In advanced breast cancer, if no response is seen, dosage may be increased to 40 mg (four NOLVADEX tablets, or two NOLVADEX-D tablets) once daily.
OVERDOSAGE
On theoretical grounds, an overdosage would be expected to cause enhancement of the pharmacological side effects mentioned above. Observations in animals show that extreme overdosage (100 to 200 times the equivalent of the recommended daily human dose) may produce oestrogenic effects.
There have been reports in the literature that NOLVADEX given at several times the standard dose may be associated with prolongation of the QT interval of the ECG.
There is no specific antidote to overdosage, and treatment must be symptomatic.
In relation to your question concerning effects on your vision:
A number of cases of visual disturbances, including infrequent reports of corneal changes, and retinopathy have been described in patients receiving NOLVADEX therapy. An increased incidence of cataracts has been reported in association with the administration of NOLVADEX.
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