good questions from everyone. I love this stuff!! This comment sub's me to this thread..
As it turns out, forskolin exerts its thermogenic and lipolytic actions via cAMP activation in adipocytes. It does this completely independently of epinephrine and stimulants. By activating cAMP in adipocytes, forkolin activates an enzyme, hormone-sensitive lipase (HSL), that modulates the liberation of fatty acids from adipocytes to be metabolized for energy. This induces significant lipolytic action.
Furthermore, forskolin stimulates thyroid function, not only by enhancing the production of the thyroid hormones, T4 and T3, but also by promoting the conversion of T4 to the more bioactive T3. Forskolin does this via modulation of the action of the enzyme type II deiodinase. This enhanced thyroid activity ultimately leads to enhanced thermogenic action.
Relatedly, forskolin also exerts cAMP-dependent anti-catabolic action. In particular, muscle-tissue breakdown is modulated by calpains. These are calcium-dependent enzymes that are themselves inhibited by agents known as calpastatins. Now, calpastatin activation is cAMP-dependent. Consequently, by activating cAMP, forskolin triggers calpain inhibition via calpastatin recruitment. This calpain inhibition ultimately leads to lean-tissue preservation, and an enhancement of the lean mass:fat mass ratio.
Enjoy your stack!
Do you guys have anything to increase height?
나는 2000년 10월 매들린 올브라이트 전 미 국무장관 매들린 사랑, 그 중 한 뜨거운 젠장!
Now, OEP was specifically designed as an extremely potent stim-based fat burner that is targeted at both generalized and localized annihilation of excess adipose tissue, based on a tight selection of ingredients with both unique and synergistic thermogenic and lipolytic pathways. In particular, OEP activates the so-called mitochondrial uncoupling protein - 1 (UCP-1), a protein that enhances mitochondrial cellular metabolism by directly stimulating the breakdown of stored fatty acids for the generation of energy. This action of fat breakdown and thermogenesis is exerted without stimulating the central nervous system, and occurs in the absence of exercise. So, by recruiting UCP-1, and increasing the resting metabolic rate, OEP supports thermogenesis and lipolysis. Related to this, OEP also supports elevated metabolic action via enhancing thyroid-hormone output [higher T4 and elevated T4-to-T3 conversion] for unprecedented fat loss. Further fat loss is ensured by inhibition of alpha2-adrenoceptor activity [the alpha2 receptor amply located in adipocytes is not only cAMP-inhibiting, but also strongly antilipolytic]; activation of beta-adrenergic receptors [especially beta3 adrenoceptors] that not only activate cAMP, but also induce significant lipolysis. [Please see my earlier post on the implication of cAMP activation for lipolysis and anti-catabolism]. Combine all these with OEP's induction of fat-loss via powerful targeting of subcutaneous fat deposits, and you have a highly specialized product with an unmatched efficacy for localized and generalized elimination of excess fat deposits.
All in all, Recreate and OEP can be used independently of each other for superior fat-burning, but nevertheless will make an extremely effective and synergistic fat-loss stack. **
I had to type my posts on this page on my cell phone, so the whole thing looks quite "bunched up". Sorry!
IF we have the forslean 95% extract from USP, is that something to combine w/ the recreate/oep stack? Or does recreate have enough forskolin?
I just got back home and reviewed the literature that came with OEP a little while ago - two questions:
You guys advocate cutting back to four meals a day. It seems like the literature is more directed to people who just want to lose weight period than people who are cutting fat while still putting on muscle. If you were still aiming to put on lean mass, would it really be best to cut back on the meals and keep the carbs so low? I'm planning on running one of my bottles during a lean bulk, where I would be cycling carbs (averaging 180g a day - some days 220+, some days below 180 - I would normally bulk at 380g+ per day) and I'm just wondering if the fat burning would be as effective as cutting down to four meals a day with low carbs.
I would also like anybody's opinions on or experiences with stacking OEP and a product like TestoPro or Phyto-Testosterone. It seems like OEP and a test booster would be a great combo for lean mass and melting the fat off.
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Would you recommend a CLA product stacked with OEP? If so, any suggestions(which brand)? Any other things to potentially stack other than your Recreate, etc. I ordered my OEP but it hasn`t arrived yet. I was hoping to start it tomorrow.
Strategicmove, thank you for your very informative responses. This is great information in this thread for sure! I am giving you reps once I figure it out. LOL I work with computers and love technology but don't post/use message boards enough to figure this sh!t out. I really only ever read them.
EDIT: HAHA, figured it out!