HiTech and IGF-1

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  1. I'm very interested in this as well. I caught the same article that is posted here over the weekend and right away I thought about giving this a run. I figure I might as well. Closing in on 40 years old, this is ideal for me.




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    Gaspari Nutrition Board Representatives Manager
    Head Gaspari Nutrition Representative
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  2. Quote Originally Posted by HTGduck View Post
    Isnt the half-life of IGF1 like 15 minutes?
    IGF DES is 20 min
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  3. Quote Originally Posted by cobri66 View Post
    How are you not convinced HiTech uses it?.Jared bought a pharmaceutical company for the sole purpose of using their technology for the cyclosome delivery
    Or to make it look like he was using fancy technology. Nothing quite like a few fancy pieces of machinery to wow the public!

    Anyone notice how many of these products existed pre cyclosome technology and ended up costing the same price after the technology was supposedly employed? These products tend to list the beta-cyclodextrin and phosphatidylcholine as just added ingredients...(?) If such products do actually have fancy delivery systems...it stands to reason that the price tag would increase.

    Other products with enhanced delivery do actually show the key ingredients bonded with B-cyclodextrin, Phosphatidylcholine(PhytoFUSE) , etc.. Then there is Tomatidine-Shilajit complex as well. Products that show these types of bonds tend to cost a great deal more than other products offering the same ingredients because I think the technology is actually being utilized in these instances..

    Cyclosome technology just seems to be a catch phrase for HiTech and many other companies as well..

  4. Quote Originally Posted by shockrock3 View Post
    P. Arnold essentially said cyclosome technology is a f'in joke.
    First result in Google, LOL. Ouch.

  5. Ether and ester should be used more often as well as it's over looked.
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  6. Quote Originally Posted by patrick25 View Post
    Ether and ester should be used more often as well as it's over looked.
    elaborate

  7. Molecular Nutrition changed the game with the pro hormone ether gels but after they stopped it died. Ether may increase IGF-1.

  8. Quote Originally Posted by patrick25 View Post
    Molecular Nutrition changed the game with the pro hormone ether gels but after they stopped it died. Ether may increase IGF-1.
    maybe, but likely without any discernable benefit making it worth purchasing a bottle for even $5

  9. Quote Originally Posted by HTGduck View Post
    Isnt the half-life of IGF1 like 15 minutes?
    People seem to not realize that they can already consume IGF-1 orally and see increased blood levels...the problem is it only does so at a very small amount CURRENTLY. Jared doesn't release stuff on a whim, so I believe him when he says he has the capability to significantly increase bioavailability

    https://www.ncbi.nlm.nih.gov/pubmed/16293962

    Insulin-like growth factor (IGF)-I is a polypeptide that mediates the growth-promoting action of growth hormone in postnatal animals. The present study was conducted to examine whether orally administered IGF-I would be absorbed into the general circulation and also whether ingested IGF-I would enhance the growth of whole body as well as internal organs, and tissues in 3-week-old ICR-strain female weanling mice. In experiment (Exp) 1, a total of 70 mice received IGF-I orally at 1 microg.g-1 in 0.2-ml PBS or the vehicle alone. Concentrations of IGF-I and glucose in heart blood were measured after killing 5 animals in each group every fourth hour during a 24-hour period. In Exp 2, a total of 40 mice received oral IGF-I administration at 1 microg.g-1 or vehicle every third day beginning from day 0 for a 13-day period. Half the animals were killed at day 7 and the other half at day 13. Weights of whole body and organs/tissues (small intestine, liver, thigh muscle, and brain) were measured every day and at slaughter, respectively. In Exp 1, following the oral IGF-I administration, serum IGF-I concentration increased at hour 4 (p<0.01) and returned to the hour 0 level by hour 8, whereas glucose concentration was lowest at hour 4 and returned to the hour 0 level by hour 16. In the PBS-fed group, neither IGF-I nor glucose concentration changed during the 24-hour period. In Exp 2, weight of small intestine increased (p<0.05) in response to the oral IGF-I, whereas weights of liver and thigh muscle of the IGF-I-fed group were greater (p<0.01) and tended to be greater (p=0.06), respectively, than those of the PBS-fed only at day 13. However, brain weight and serum concentrations of IGF-I and IGF-II were not affected by oral IGF-I administration. Results suggest that although orally administered IGF-I mainly acts at the intestine, a portion of ingested IGF-I is absorbed into the general circulation to enhance the growth of selective organs/tissues in weanling mice.
    Hi-Tech Pharmaceuticals Representative Manager

  10. Quote Originally Posted by VaughnTrue View Post
    People seem to not realize that they can already consume IGF-1 orally and see increased blood levels...the problem is it only does so at a very small amount CURRENTLY. Jared doesn't release stuff on a whim, so I believe him when he says he has the capability to significantly increase bioavailability

    https://www.ncbi.nlm.nih.gov/pubmed/16293962
    lettuce also have him concoct oral insulin and change the lives of millions of diabetics. jared da gawd is a compassionate gawd

  11. But what about the humans
    Serious Nutrition Solutions Representative
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  12. Quote Originally Posted by Jiigzz View Post
    But what about the humans
    Why would that matter?

  13. Quote Originally Posted by rascal14 View Post
    Why would that matter?
    Not sure if cereal, but in case you are, a mouse is only a useful prelim tool for how things will affect a human. We can use it as a basis for future enquiry, but not to substantiate evidence for human use
    Serious Nutrition Solutions Representative
    X-gels for strength, Focus XT for mental performance & Joint Support XT for pain free mobility

  14. If I were a mouse, Id have a gutsful of being used for oral igf-1 studies.

  15. Quote Originally Posted by Jiigzz View Post
    Not sure if cereal, but in case you are, a mouse is only a useful prelim tool for how things will affect a human. We can use it as a basis for future enquiry, but not to substantiate evidence for human use
    I was definitely joking lol

  16. Quote Originally Posted by rascal14 View Post
    I was definitely joking lol
    I'm terrible at this lol. I had thought as much
    Serious Nutrition Solutions Representative
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  17. Quote Originally Posted by rascal14 View Post
    Why would that matter?
    Quote Originally Posted by Jiigzz View Post
    Not sure if cereal, but in case you are, a mouse is only a useful prelim tool for how things will affect a human. We can use it as a basis for future enquiry, but not to substantiate evidence for human use
    lol'd
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  18. Quote Originally Posted by rascal14 View Post
    Why would that matter?
    A lot of things (in breast milk) work great for human babies - but your adult digestive tract will destroy the shjt out of them. Like I said, MK-677, a fairly tested experimental drug, gives 20 year old levels to 40 year old's - but the mass ain't exactly packing on even with that *drug* (and it needs to be taken...forever?... for even the longevity benefit). They've shown that the use of bovine growth factors makes it into milk and raises levels in people - and uh...so? Is your sister or mom jacked? Just because a number increases by X, doesn't mean it has real world significance.


    Edit: Disregard, just saw you were joking

  19. Quote Originally Posted by Big Papi View Post
    lettuce also have him concoct oral insulin and change the lives of millions of diabetics. jared da gawd is a compassionate gawd
    considering there is already inhalible insulin, I'd say we're not too far off from that goal: http://www.healthline.com/diabetesmi...in-gets-real#1



    Guys, I understand the criticism, but the amount of straight up hate in here is laughable. Everyone always demands more innovation, more new ingredients, and more cool stuff...and when a company claims to have something new, everyone jumps on the hate bandwagon and claims bull**** before seeing ANY evidence whatsoever.

    I'll remain cautiously optimistic in the meantime. Have fun with the hate yall.
    Hi-Tech Pharmaceuticals Representative Manager

  20. Quote Originally Posted by VaughnTrue View Post
    considering there is already inhalible insulin, I'd say we're not too far off from that goal: http://www.healthline.com/diabetesmi...in-gets-real#1



    Guys, I understand the criticism, but the amount of straight up hate in here is laughable. Everyone always demands more innovation, more new ingredients, and more cool stuff...and when a company claims to have something new, everyone jumps on the hate bandwagon and claims bull**** before seeing ANY evidence whatsoever.

    I'll remain cautiously optimistic in the meantime. Have fun with the hate yall.
    Well, idk if you were bunching up my comment but I clearly asked for evidence nothing more. My worry is that most supplement companies make BOLD claims like these which dont pan out with anything weve seen so far in the real world without showing any scientific data to back it up. If that scenario doesnt make you skeptic, you have a serious gullible problem. If they just release ANYTHING that remotely shows this will work other than "unsupported claims", id be the first to get excited about it and possibly give it a shot.

    Until then, color me skeptic.

  21. Let's fix SP250 first before we tackle oral IGF shall we? If we can't solve why a preworkout is putting people to sleep.....

  22. Quote Originally Posted by hazard12 View Post
    Well, idk if you were bunching up my comment but I clearly asked for evidence nothing more. My worry is that most supplement companies make BOLD claims like these which dont pan out with anything weve seen so far in the real world without showing any scientific data to back it up. If that scenario doesnt make you skeptic, you have a serious gullible problem. If they just release ANYTHING that remotely shows this will work other than "unsupported claims", id be the first to get excited about it and possibly give it a shot.

    Until then, color me skeptic.

    Then be patient and wait to see the products/ingredients/claims.

    Quote Originally Posted by shockrock3 View Post
    Let's fix SP250 first before we tackle oral IGF shall we? If we can't solve why a preworkout is putting people to sleep.....
    SP250 does not put me to sleep. Sorry to hear that you have that effect with it.
    Hi-Tech Pharmaceuticals Representative Manager

  23. Quote Originally Posted by shockrock3 View Post
    Let's fix SP250 first before we tackle oral IGF shall we? If we can't solve why a preworkout is putting people to sleep.....
    I haven't heard about this at all. SP250 makes me NOT want to sleep. I haven't heard anyone having that issue
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  24. Quote Originally Posted by ManimalPatB View Post
    I haven't heard about this at all. SP250 makes me NOT want to sleep. I haven't heard anyone having that issue
    Dude I'm not going to argue with you...you've seen the reviews "outside" of Hi-Tech/Gaspari reps, where of course SP250 works incredibly (honestly I wouldn't expect a rep to give a honest opinion on their own product). Nobody gets any energy from SP250, none. It's non-existent, no stimulation, nothing.

  25. Quote Originally Posted by shockrock3 View Post
    Dude I'm not going to argue with you...you've seen the reviews "outside" of Hi-Tech/Gaspari reps, where of course SP250 works incredibly (honestly I wouldn't expect a rep to give a honest opinion on their own product). Nobody gets any energy from SP250, none. It's non-existent, no stimulation, nothing.
    the DMAA thread over on another popular forum has numerous users in a row (non reps) saying they prefer SP250 over just about every DMAA product out there. I understand you don't enjoy it, but to say no one else does is just erroneous.
    Hi-Tech Pharmaceuticals Representative Manager
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