the goal with DAA
- 08-13-2010, 08:24 PM
Also, I wouldn't worry about 60 days. You can always cut it short if you get a bad vibe, but 60 sounds like a good plan with your stack.
- 08-14-2010, 12:50 AM
08-14-2010, 07:30 AM
You are not alone, my friend! I have always argued for a preference of (I3C) over Di-Indolyl-Methane (DIM). As is well known, apart from helping neutralize harmful estrogen metabolites by triggering so-called Phase I and Phase II detoxifying enzymes, indole-3-carbinol also favourably improves the ratio of "good" estrogens to "bad". In particular, it raises the levels of the beneficial 2-hydroxyestrone compared to that of the harmful 16-hydroxyestrone, in addition to supporting the stabilisation of DIM levels. On its part, DIM, the I3C metabolite, specifically addresses the potentially harmful estrogen metabolite called 4-hydroxyestrone. Both I3C and DIM may induce deceased-cell apoptosis and trigger DNA repair. Overall, several metabolites can be synthesized from I3C, including DIM. As a consequence, I3C has a broader set of beneficial biological actions than DIM. If I had to choose one of the two, it would be I3C. Nevertheless, the two can also make a nice stack.Originally Posted by DR.D;
Product Educator | USPowders
Statements made by this online persona are the sole property of the owner, and do not necessarily reflect USPowders opinion as a whole.
08-14-2010, 12:28 PM
08-14-2010, 12:34 PM
08-14-2010, 01:20 PM
Magnesium balances Calcium. Ideally you should get about 400mg elemental Mg and 1000mg elemental Ca per day, to balance. It's pretty easy to get that much Ca in your diet, but not as easy to get the Mg you need. That's why I supplement Mg every night.
I do think many women can benefit from Ca supps though.
What bulk stuff? Was it pure DAA, or a racemic blend, or a salt?
08-14-2010, 01:30 PM
It was bulk stuff from Nutra. I felt more aggressive and the effects more pronounced but it was sure rough. Interesting on the magnesium. I supplement zinc with how much milk I drink but I guess its common sense to include the magnesium too. About how much do you/would you use together? I can adjust accordingly, just looking for a baseline...whats your response to the people who think DAA is an excitotoxin etc. Seems like some scare tactics...you know, now that I think about it, Id love to see all the stuff you supplement on the daily grind and so on. Thanks D, youre always real helpful!
08-14-2010, 03:11 PM
'Excitotoxins like NMDA and kainic acid which bind to these receptors, as well as pathologically high levels of glutamate, can cause excitotoxicity by allowing high levels of calcium ions (Ca2+) to enter the cell. Ca2+ influx into cells activates a number of enzymes, including phospholipases, endonucleases and proteases such as calpain. These enzymes go on to damage cell structures such as components of the cytoskeleton, membrane, and DNA.'
08-14-2010, 04:36 PM
08-14-2010, 06:05 PM
I don't know, I haven't tried it. I don't anticipate that I will either, because each 3.45g serving calculates out to 808mg Calcium per scoop! That product's label claims you're only getting 451mg Ca per scoop, but the molecular weight of Ca (40.08) divided by the molecular weight of Ca-DAA (171.16) then multiplied by 3.45g adds up to 808mg. That also suggests that you're only really getting about 2.6g of DAA per dose, but that's an adequate amount IMO, so it should still work at least. But I'm not some middle-aged osteoporotic woman for goodness sake, that's just way more daily Calcium than I want, especially stacked with a potential excitotoxin that works by Calcium flux through NMDA receptors.
Perhaps you should ask Mr. Patrik Westberg about the toxicity of Ca-DAA? His write-up is word for word the same as the product you mentioned. Hmmmm... go figure.
08-14-2010, 06:10 PM
08-14-2010, 06:17 PM
08-14-2010, 06:31 PM
08-14-2010, 06:33 PM
08-14-2010, 08:28 PM
08-14-2010, 09:24 PM
Hey John, what is your take on NMDA, I personally prefer it over DAA, although DAA is effective. If cycled, can it be fine for overall brain health in your opinion? I know there are lots of factors since NMDA intake can be productive to some.
doing my own thang!
08-14-2010, 11:20 PM
DAMN, glad Ds droppin some knowledge around here. Always interesting to read Ds post, i wish he answered as many questions of mine as he answers here, you guys are lucky
08-14-2010, 11:32 PM
On a related, I finally got my DAA. I feel like a caveman here, but I'll be giving it a whirl to see what all this hype is about.
08-15-2010, 09:25 AM
Excellent thread everyone. Don't know who you are, Dr. D, but you use lots of words that have me reading Wikipedia and journal articles (ok, abstracts) for hours. I like.
Got a question: has anyone tried Anabolic Xtreme's Axcite Magnum? I recently ordered a bottle on a whim--not sure if that was a great idea--but I'm not sure how much DAA is actually in it since they use a proprietary blend. One cap has 819 mg and you're supposed to take 2-3 AM and 2-3 PM. DAA is listed 2nd, after ginseng. The other two ingredients are icariin and pine bark extract. Also, I've got about 1 week left on an 8-wk 800 mg ED Testofen cycle. Can I overlap the DAA or should I take a break?
08-15-2010, 11:32 AM
08-15-2010, 12:05 PM
08-15-2010, 01:17 PM
The pKas are only 3.86 and 2.10 for the sidechain H's due to resonance, so I guess you could pop them off pretty easy. If nothing else, a fun little biochem review.
I ordered the DAA in May, but was away most of the summer.
08-15-2010, 02:08 PM
08-15-2010, 02:13 PM
08-15-2010, 02:42 PM
08-15-2010, 02:59 PM
08-15-2010, 03:12 PM
08-15-2010, 03:22 PM
08-15-2010, 03:52 PM
08-15-2010, 07:35 PM
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