the goal with DAA

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    Quote Originally Posted by Primal2 View Post
    I cant believe some of you guys are still stuck on the 12 day thing. The 12 days study was done because that's how long the study was for. That's all! In fact its recommend to take for a 90 day period by people who paid for the study. I already posted about it before on these forums. I'll have to dig up the link again...
    Keep in mind it's still a relatively new compound. I mean, why be a guinea pig when there could be a potential excitotoxic concern?

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    Quote Originally Posted by Primal2 View Post
    Being Chelated, it is more bioavalible and ingested very easily compared to the clump of daa powder sitting in your small intestine.
    Really? You have studies to show this? because again, your body still has to cleave the calcium from the aspartate, and DAA's molecular weight is relatively tiny so it should pass through intestines fairly readily.
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    I would expect the best way to mitigate DAA effects would be to load it @ 3g for 15 days and then use a low maintenance dose - it accumulates in the target tissues, and a low circulating level may prevent excitotoxic sides. I would also use a low dose AI, as this should be very synergistic with DAA.
    Paging Dr. Banner. . .
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    Quote Originally Posted by fanzdslpwr View Post
    well i can't wait for the testforce to arrive. hey lonewolf how much did you take daily of the testforce? 3 grams or 6 grams? i never loaded the DAAPURE but I had great physical results.
    I dose 3g each day. 6g a day isn't cost effective for me.
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    Also, note that in the 12 on/off study, the T boost tapered off slowly, while users report anxiety ceasing soon after discontinuation.
    Paging Dr. Banner. . .
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    Quote Originally Posted by Primal2 View Post
    Has nothing to do with cholesterol, I got this from another forum and they aren't my words.

    "DAA is thought to increase LH, FSH and test by interacting with the hypothalumus to produce increased concentrations of GnRH which will stimulate the pituitary to release LH and FSH, which then mediate test release and sexual function in the testes."
    DAA works by several mechanisms. One of which is to increase the StAR mediated uptake of cholesterol in the testes.

    Quote Originally Posted by Unclebuck View Post
    I'm not in the same league with Dr.D. but I'm gonna go on record and say this stuff is going the way of the dinosaur. I've read enough to believe that DAA is an excitotoxin. Why don't you read up on that and all that it entails.(The LEAST of which is anxiety, which I do believe it can cause or contribute to.) I've never felt that the 40 percent test rise would do anything at all as far as strength/muscle building. I also believe that the effects on libido level off fairly quickly. Its been out long enough to form some opinions. Where are the posts that state that it actually did something? They are all vague. If this was a keeper we would know it by now. I am not a negative guy and I love my supplements so if I am wrong, somebody show me.
    Quote Originally Posted by Patrick Arnold View Post
    we are not injecting DAA into our brains. I have read the studies where they use nmda to induce neuronal death and they produce localized concentrations that are magnitudes greater than could ever be acheived by oral ingestion of DAA at realistic dosages.

    Dont forget that DAA is an endogenous substance with a vital neuroendocrine role. Its not some toxin that your body makes as a byproduct or something
    Quote Originally Posted by Patrick Arnold View Post
    certainly the levels are higher than normal, but they simply do not approach levels (at target areas) seen in studies where NMDA is used as a tool to induce nerve damage

    you are entitled to your opinion and if you choose to err on the side of caution and not use the product thats fine. i understand you are not saying "its dangerous" and you are simply asking if i am concerned about the potential.
    Quote Originally Posted by Patrick Arnold View Post
    d-serine (and cycloserine) is also an agonist at the NMDA receptors. The difference is that it is concentrated in tissues other than the endocrine related ones that DAA and NMDA are. It actually has had alot of research done on it as a treatment for schizophrenia, and at doses of 2-3 grams a day. It is considered thusfar to be safe. You could make the same case that you are making here with DAA with this investigational drug.

    I just say this so you dont think i am a nut outside the realm of responsible medical science.
    Quote Originally Posted by Patrick Arnold View Post
    the italian group that funded the study recommends their daa product be taken for 90 days btw.

    i am not worried about bad estrogen. no reason why a larger dose would cause any change in test estrogen ratio, and it is the ratio that matters NOT total E

    prolactin is usually a problem only in an estrogen dominant environment and that should not happen with this stuff.

    btw did you know that prolactin is very similar in amino acid sequence to GH, and shares much of its anabolic properties? i am not saying prolactin is the best thing but sliced bread but its not 100% evil either
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    I don't think prolactin is really an issue with this supplement. alot of the aspartic acid supplements coming out have anti prolactin ingredients like T-UP and NMDA by Muscle warfare
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    Quote Originally Posted by lonewolf0420 View Post
    I've been through two containers of the TestForce, and never had this kinda feeling. I guess I just wait and see if its coincidence or not.

    Along with taking my DAA in the morning, I'm also taking OxyElite and LX upon waking.
    Yeah, it's that NMDA activating effect. The DL form is really bad about it as I mentioned earlier. Anytime you get that feeling strongly, you may be extra sensitive or your source may have supplied you with DL. Out of all the raw materials I tested, 3 out of 4 that claimed to be D were really DL. Be careful and stick with a supplier who does analysis by Polarimetry.

    Also, I've noticed that pretreatment with a racetam (piracetam, aniracetam, etc..) seem to attenuate the right NMDA sub-receptor to discourage the CNS sides from DAA, without interfering with the endocrine benefits.
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    Quote Originally Posted by EasyEJL View Post
    no, they aren't. Testforce is D-Aspartate Calcium Chelate. So theres likely a difference in time it takes for the body to strip the calcium off, so the DAA is released into bloodstream slower, rather than a lump all at once.
    Combining Calcium with DAA can increase it's efficacy, but also it's side effects unfortunately. I don't like to take extra Calcium beyond what I get in my diet. It promotes kidney stones over time (especially in juicers) and reduces the absorption and benefits of magnesium (which I do supplement every night.)
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    I figure since I'm probably well saturated, I'm gonna try dropping the dose by 650mg.
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    propadrol ep has some daa along with an ai... your thoughts

    propadrol ep:
    7-methoxy-2-phenyl-4h-chromen-one, 3,5,7-trihydroxy-4 methoxyflavone 200 mg

    D-Aspartic Acid & N-Methyl-D-Asparate 3 g
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    Quote Originally Posted by DR.D View Post
    Combining Calcium with DAA can increase it's efficacy, but also it's side effects unfortunately. I don't like to take extra Calcium beyond what I get in my diet. It promotes kidney stones over time (especially in juicers) and reduces the absorption and benefits of magnesium (which I do supplement every night.)
    Considering the protein we eat, the amount of vitamins we take, and the fact that a lot of people on this site juice, we should probably all be requesting the NP carries some type of bulk kidney cleansing formula.
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    Quote Originally Posted by kingdong View Post
    Considering the protein we eat, the amount of vitamins we take, and the fact that a lot of people on this site juice, we should probably all be requesting the NP carries some type of bulk kidney cleansing formula.
    Magnesium Citrate for starters. That covers many, many bases.

    But yeah, I agree. People remember their livers, but generally neglect there kidneys. Juice markedly increases the retention of 3 elements: Nitrogen, Calcium and Phosphorus, and Calcium Phosphate is a common constituent of kidney stones. Not to mention, most people don't drink enough water. Magnesium and Potassium (especially the citrate forms) are good insurance to antagonize ureterolithiasis formation.
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    Well I dropped my dosage by 650mg, and I felt no onset of anxiety like I felt the past couple of days. I feel relaxed, this morning. I also took my phenibut again this morning, so I'll see how I feel after dosing tomorrow (I don't take phenibut on the weekends)
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    the other option of course would be to spread the dose out. since it sounds like the anxiety is sort of acute, shortly after taking it, maybe by less of an influx at once it would disappear?
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    My thought as well.

    Usually upon waking, is the only time I'm actually on an empty stomach. So certain supplements I will only dose at that time.
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    spreading out did not help with daa for me
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    I will try the E-PHARM brand testforce when it comes in either saturday or monday.
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    Someone mentioned it made their urine smell like cat piss. Anyone experience a stool that smells fishy?
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    not exactly fishy, but an odd smell, maybe a bit like elephant dung.
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    I've been on the bulk DAA for 3 days now. I smell nothing when I go.. I did the TCF-1 a while back & really liked it. Hoping to see the same results from the bulk.
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    Something is wreaking havoc ( Oder wise) on me.
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    I sweat all day @ work, going through 3 shirts a day. I ALWAYS stink! Lol.
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    Quote Originally Posted by DR.D View Post
    Magnesium Citrate for starters. That covers many, many bases.

    But yeah, I agree. People remember their livers, but generally neglect there kidneys. Juice markedly increases the retention of 3 elements: Nitrogen, Calcium and Phosphorus, and Calcium Phosphate is a common constituent of kidney stones. Not to mention, most people don't drink enough water. Magnesium and Potassium (especially the citrate forms) are good insurance to antagonize ureterolithiasis formation.
    Indeed. Pyridoxamine, one of the more bioactive Vitamin B6 forms, is another compound that exerts a powerful kidney protection function, in addition to its other benefits, including protecting against the deleterious cellular effects of the cross-linking of proteins and carbohydrates.
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    Quote Originally Posted by strategicmove View Post
    Indeed. Pyridoxamine, one of the more bioactive Vitamin B6 forms, is another compound that exerts a powerful kidney protection function, in addition to its other benefits, including protecting against the deleterious cellular effects of the cross-linking of proteins and carbohydrates.
    Strategic, you have any recommendations for Pyridoxamine. Can't really find anything except for Life Extension. Also seen where true form has been banned by FDA for over the counter because pharma company is looking to use it for diabetic patients.
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    Quote Originally Posted by bludevil View Post
    Strategic, you have any recommendations for Pyridoxamine. Can't really find anything except for Life Extension. Also seen where true form has been banned by FDA for over the counter because pharma company is looking to use it for diabetic patients.
    What do you mean by "recommendations"?
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    supplement wise. Any brands that you like
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    Quote Originally Posted by bludevil View Post
    supplement wise. Any brands that you like
    Life Extension Foundation is the only one I trust, as far as this compound goes.
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    Quote Originally Posted by strategicmove View Post
    Life Extension Foundation is the only one I trust, as far as this compound goes.
    Stacking this B6 vitamer with Carnosine could be a potent anti-AGEs strategy as well.
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    Quote Originally Posted by DR.D View Post
    Stacking this B6 vitamer with Carnosine could be a potent anti-AGEs strategy as well.
    Absolutely. That is, in fact, the classic combo.
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    whats the difference between Pyridoxamine and p5p ??

    i take NOW p5p does this have the same anti aging benifits?
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    Quote Originally Posted by giantbrandon View Post
    whats the difference between Pyridoxamine and p5p ??

    i take NOW p5p does this have the same anti aging benifits?
    I think it probably does because P5P converts to the phosphated form of Pyridoxamine in some reactions, but to what degree I'm unsure. Perhaps strat can chime in.
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    some good daa info in here...thanks guys!
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    Quote Originally Posted by giantbrandon View Post
    whats the difference between Pyridoxamine and p5p ??

    i take NOW p5p does this have the same anti aging benifits?
    The three vitamin B6 forms, pyridoxine, pyridoxal, and pyridoxamine, are all precursors to the coenzyme form, pyridoxal 5'-phosphate (P5P or PLP). Pyridoxamine is the form that has been shown to have the most important impact on AGEs-related anti-aging considerations. Nevertheless, P5P, like Dr. D suggested, should also exert related benefits.
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    Quote Originally Posted by DR.D View Post
    I think it probably does because P5P converts to the phosphated form of Pyridoxamine in some reactions, but to what degree I'm unsure. Perhaps strat can chime in.
    Like pyridoxine and pyridoxal, pyridoxamine conversion to the coenzyme form, pyridoxal 5-phosphate (P5P or PLP), occurs via a sequential action of phosphotases, kinases, and oxidases. In particular, pyridoxamine is ultimately converted to PLP via intestinal phosphatase hydrolysis, and enzymatic actions of pyridoxal kinase and pyridoxine 5-phosphate oxidase.
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    Quote Originally Posted by strategicmove View Post
    Like pyridoxine and pyridoxal, pyridoxamine conversion to the coenzyme form, pyridoxal 5-phosphate (P5P or PLP), occurs via a sequential action of phosphotases, kinases, and oxidases. In particular, pyridoxamine is ultimately converted to PLP via intestinal phosphatase hydrolysis, and enzymatic actions of pyridoxal kinase and pyridoxine 5-phosphate oxidase.
    You must spread some Reputation around before giving it to strategicmove again.

    lol
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    Greetings.

    I plan on going on a Lean Xtreme, TestoPro, and bulk DAA run for 60 days. Lean Xtreme will only dosed at 2 caps/day, TestoPro 4/day, and DAA 3 g/day.

    Do you see a possible issue with the proposed stack?

    Thank you.
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    Quote Originally Posted by abbazaba View Post
    Greetings.

    I plan on going on a Lean Xtreme, TestoPro, and bulk DAA run for 60 days. Lean Xtreme will only dosed at 2 caps/day, TestoPro 4/day, and DAA 3 g/day.

    Do you see a possible issue with the proposed stack?

    Thank you.
    Looks like a nice combo!
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    Glad that you agree.

    I thought it has everything and couldn't pass it up - testofen, forskholii, 7-OH, divanyl, DAA.

    Only thing I am worried about is that it will be a 60 day cycle.
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    Also, instead of an AI, I figured I'd try I3C - I am actually going to get some extra I3C on top of what is in TestoPro.
  

  
 

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