Hey J, it kinda builds up in your system so if you take right from the start, sometime 20 is good enough, but usually 40 before it's all over. I never go higher than 40, I'm supp. with tret cream if needed. Never had a bad liver check at 40mg or less. As for the mino, if you take a little break every now and then it will work better when you start back. Oh yeah, take the acc w/ food it helps absorbsion.