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Jan's BloodTest April13/2007

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  1. Professional Member
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    Dr Shippen Chart


    Link to (TT, SHBG, FreeT) chart
    http://www.andropause.org.uk/nomo_tas.pdf

    The Andropause Society Home


    ============================== ============================== ==========
    Dr Shippen Chart

    Testosterone Conversion Factor: pg/ml x 3.47 = pMol/L

    Androgen deficiency in the adult ... - Google Books

    Androgen Deficiency in the Adult ... - Google Book Search

    This chart is from a book (second page from the top):

    Androgen Defficiency in the
    Adult Male
    causes, diagnosis and treatment
    by
    Malcom Carruthers

    printed by Taylor and Princes Group

    search on keyword
    nomogram androgen deficiency carruthers
    Attached Images Attached Images     

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    Interesting....i applied my last two tests - used my shgb and TT and used this to calculate FreeT, and this chart resulted in almost 2x the Free t compared to my Quest results.
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    Quote Originally Posted by AnotherOldGuy View Post
    Interesting....i applied my last two tests - used my shgb and TT and used this to calculate FreeT, and this chart resulted in almost 2x the Free t compared to my Quest results.
    I am not surprised.
    Was your FreeT assayed or calculated by Quest.
    There is at least two ways (probably more) to get number that is called FreeT.
    FreeT and BioAvailableT tests are notoriously inaccurate (grossly, over 200%).
    The chart is a fall-back way out of this confusion.
    Dr Shippen uses this chart (if that would help getting some confidence).

    The chart is 1999 vintage, made based on science of about 1990.
    To my knowledge there are at least two items that greatly influence results in rather uncontrolable ways;
    recently discovered duality of SHBG
    and
    fact that age of person being tested influences results.

    Wish Dr John had a time to discuss this issue.


    AnotherOldGuy, hopefully this issue will bother you enough so you will dig deeper, if you find anything helpfull and relevant please post it right here or open new thread.
    Not sure yet, but I think older guys are infueced more by this than younger whipper snappers.

    In this post
    Anabolic Steroids and Bodybuilding - View Single Post - Attention all those on Sub-q injections

    I have made attempt at calculating FreeT using internet provided calculator.
    Since results come widely scattered I no longer have confidence using it.

    age-associated Bio-T
    age-associated Bio-T
    •   
       

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    My list for blood testing, long, for once/year testing.
    Latter will add shorter list, for 2-3/year corrective action, tweaks.
    Below are my ICD-9 codes that helps with insurance.

    Also place to buy syringes for Testosterone and HCG.
    (I modify this list as I learn about my preferences, if you follow this list, please check it shortly before you make test request)
    Print from here down to the next blue text.
    This list is meant to be done at LabCorp.com

    ============================== ==================

    1 --------- Comprehensive Metabolic Panel w/EGFR
    2 --------- CBC w/ diff/PLT
    3 --------- VAP TM Cholesterol Test
    4 --------- Selenium, Whole Blood
    5 --------- Copper, serum
    6 --------- Zinc
    7 --------- Magnesium, RBC
    8 --------- Potassium, RBC
    9 --------- C-Reactive Protein (CRP), Highly Sensitive, CSF
    10 --------- Fibrinogen
    11 --------- Homocysteine, cardio
    12 --------- Lipoprotein (A) Lp(A)
    13 --------- Iron and Iron Binding Capacity
    14 --------- Iron, Total
    15 --------- Ferritin
    16 --------- Transferrin
    17 --------- Folate, RBC & Hematocrit
    18 --------- Hemoglobin A1c
    19 --------- Hemoglobin, Plasma
    20 --------- VITAMIN A, E, B3, B12
    21 --------- Vitamin D, 25-Hydroxy
    22 --------- T3, Total
    23 --------- T4, Total
    24 --------- T3, Free
    25 --------- T4,Free
    26 --------- T3, Reverse
    27 --------- Ultrasensitive TSH
    28 --------- Thyroid Peroxidase and Thyroglobulin Antibodies
    29 --------- Thyroglobulin
    30 --------- Thyroxine-binding globulin
    31 --------- Insulin, serum
    32 --------- IGF Binding protein-3
    33 --------- IGF-1
    34 --------- DHEA Sulfate
    35 --------- Aldosterone
    36 --------- Renin Activity, Plasma
    37 --------- ACTH, Plasma
    38 --------- Cortisol Binding Globulin (Transcortin)
    39 --------- 7:30AM/12PM/3:30PM---Cortisol, Free and Total
    40 --------- Prolactin
    41 --------- Progesterone
    42 --------- Pregnenolone
    43 --------- Androstenedione
    44 --------- Estradiol, sensitive 140244 (3-70)
    45 --------- Estrone, Serum
    46 --------- Total Testosterone
    47 --------- SHBG
    48 --------- Albumin
    49 --------- Dihydrotestosterone
    50 --------- 3a-Androstanediol Glucuronide
    51 --------- Ceruloplasmin
    52 --------- Coenzyme Q10
    --------------------------------------------------------------------------------------------------
    244.9 ----- 257.2 ----- 780.79
    250.00 ----- 272.4 ----- 788.41
    250.01 ----- 601.9 ----- 253.3
    255.4 ----- 780.4 ----- 255.8
    783.9 -----
    --------------------------------------------------------------------------------------------------

    ============================== ============================== ===============
    End of list =========see another lis of ICD-9 codes on the bottom of this post ======
    (I modify this list as I learn about my preferences, if you follow this list, please check it shortly before you make test request)

    ICD9Data.com - Free 2007 ICD-9-CM Medical Coding Database

    244.9 Unspecified acquired hypothyroidism
    250.00 Diabetes mellitus without complication type ii or unspecified type not stated as uncontrolled 2009 ICD-9-CM Diagnosis 250.00 - Diabetes Mellitus Without Complication Type Ii Or Unspecified Type Not Stated As Uncontrolled
    250.01 Diabetes mellitus without complication type i not stated as uncontrolled 2009 ICD-9-CM Diagnosis 250.01 - Diabetes Mellitus Without Complication Type I Not Stated As Uncontrolled
    255.4 Corticoadrenal insufficiency 2009 ICD-9-CM Diagnosis 255.4 - Corticoadrenal Insufficiency
    783.9 Other symptoms concerning nutrition metabolism and development 2009 ICD-9-CM Diagnosis 783.9 - Other Symptoms Concerning Nutrition Metabolism And Development
    257.2 Other testicular hypofunction 2007 ICD-9-CM Diagnosis 257.2 - Other Testicular Hypofunction
    272.4 Other and unspecified hyperlipidemia 2007 ICD-9-CM Diagnosis 272.* - Disorders of lipoid metabolism
    601.9 Prostatitis unspecified 2007 ICD-9-CM Diagnosis 601.* - Inflammatory diseases of prostate
    780.4 Dizziness and giddiness 2007 ICD-9-CM Diagnosis 780.4 - Dizziness And Giddiness
    780.79 Other malaise and fatigue 2007 ICD-9-CM Diagnosis 780.79 - Other Malaise And Fatigue
    788.41 Urinary frequency 2007 ICD-9-CM Diagnosis 788.41 - Urinary Frequency
    253.3 Adult Onset Growth Hormone Deficiency
    255.8 Other specified disorders of adrenal glands 2007 ICD-9-CM Diagnosis 255.8 - Other Specified Disorders Of Adrenal Glands

    Anabolic Steroids and Bodybuilding - View Single Post - Adrenal fatigue, does it really exist?
    255 Disorders of adrenal glands
    For coding adrenal fatigue, I just use the code for Other Specified Disorders of the Adrenal Glands - which I call Adrenal Fatigue
    255.8 Other specified disorders of adrenal glands 2007 ICD-9-CM Diagnosis 255.8 - Other Specified Disorders Of Adrenal Glands
    HGH and Insurance Coverage
    Dr. John 12-17-2006, 06:25 AM
    ICD-9 253.3 Adult Onset Growth Hormone Deficiency
    ============================== ============================== =========================
    Spectracell codes
    244.90 Unspecified acquired hypothyroidism
    264.00 Vitamin a deficiency
    268.00 Vitamin d deficiency
    269.90 Unspecified nutritional deficiency
    780.79 Other malaise and fatigue
    799.81 Decreased libido
    ------->add something for lipids

    ============================== ============================== ===========
    EstroEssence

    that I send for on Monday Oct1/2007 had the following
    ICD-9 codes
    600.0
    606.1
    257.2
    253.4

    Genova Diagnostics EstroEssence

    The EstroEssence check the following 11 (eleven) indicators:

    Estrone (24hr urine)Male 3.00-12.00 mcg/24 hr
    Estradiol (24hr urine)Male1.50-6.00 mcg/24 hr
    Estriol (24hr urine)Male 3.00-28.50 mcg/24 hr

    2-Hydroxyestrone (24hr urine) 0.26-13.68 mcg/24 hr
    2-Methoxyestrone (24hr urine) 0.34-9.03 mcg/24 hr
    16α-Hydroxyestrone (24hr urine) 0.25-7.89 mcg/24 hr
    4-Hydroxyestrone (24hr urine) 0.33-1.95 mcg/24 hr
    4-Methoxyestrone (24hr urine) 0.40 0.20-1.60 mcg/24 hr
    2-Hydroxyestrone/16α-Hydroxestrone Ratio (24hr urine)0.94-1.56 Ratio
    2-Methoxyestrone/2-Hydroxyestrone Ratio (24hr urine) 0.11-4.00 Ratio
    4-Methoxyestrone /4-Hydroxyestrone Ratio (24hr urine) 0.18-3.60 Ratio
    ============================== ============================== =============
    The Metabolic profile that I send for on Monday Oct1/2007 had the following
    ICD-9 codes
    536.8
    579.8
    558.3
    783.2
    009.1
    ---------------------------
    Hair Tissue Mineral Analysis (HTMA)
    Hair Analysis

    At Genova they need 1" of hair from the back of head,
    approx 2 months growth,
    last 2 weeks wash hair with Johnson baby shampoo.
    Today I go to Kim for haircut, 11/16/2007, last time I had hair colored Oct12/2007
    Use stainless steel scissors
    500 milligrams has been recommended.
    minimum sample of 250 milligrams (0.25 g) for analysis
    Genova Diagnostics - Home
    -------------------------------------------------------
    Assessment Categories
    GDX Laboratory Assessment Categories
    ---------------------------------

    EstroEssence --(Cost $384.99 out of pocket $27.49)-- Genova Diagnostics EstroEssence

    EstroEssence Complete (24hr) this is the one to do next
    Check differences on taking samples NutrEval and NutrEval-NEW, want the one with 24 hr urine if there is such


    ============================== ==========================
    JanSz-Metabolic Analysis and Cellular Energy

    Jan's BloodTest April13/2007

    Magnesium, how to increase

    Endocrinological charts
    Endocrinological charts

    Bill for my blood test at Quest

    Perfect way of finding right doctor

    Jansz - more infor on methy estrone imbalnace

    GLA but AA below range

    Quality supplements (Wise Guy et alii)

    -------http://mus--clecha---troom.com/forum/showthread.php?t=395&page=2

    Symptoms, Diseases and Diagnosis - WrongDiagnosis.com

    Example of logic algoritm when using Genova tests
    Genova Diagnostics - Anti-Aging Digest

    possible underlying causes and contributing factors
    GDX Chronic Fatigue Syndrome (CFS)

    Comprehensive Nutritional Assessment
    nutritional supplement program customized to individual requirements
    https://secure.customvite.com/cvite/default.asp

    A Canary's-Eye View — Introduction

    Enzymes & Methylation
    Nutri-West Articles: HOMOCYSTEINE REDUX vs MSM
    ----------------------------------------------
    One can order over internet many/most tests, if not directly available, send e-mail, ask for it.

    Welcome to Integrative Psychiatry Mental Health Testing and Treatment

    Also interpretation of tests and some follow up actions can be discussed over telephone:
    15 minutes $45
    30 minutes $75
    Telephone Consultation
    .
    .

    Use the A4M's directory to search for anti-aging physicians, clinics, spas and products.
    Anti-Aging Physicians, Clinics & Products - WorldHealth.net


    ====================
    Quote Originally Posted by Investmentbanker View Post
    Jan, where do I go to do this? If it is an imbalance will the test results suggest what I do to correct it? Thank you for your help.
    Please do not use full name of GD labs.
    Dr John in the past was objecting.
    He does not object to discussion on health topics that the cover.
    --------------------------------------------------------
    On e-mail request include your zip code and ask for 25 or 50 miles radius, they will send you a list of doctors that have accounts with them.
    --------------------------------------------------------

    Essential & Metabolic Fatty Acids Analysis (EMFA)

    http://www.genovadiagnostics.com/ind...&nav=doc&id=47

    Sample Report:
    http://www.genovadiagnostics.com/fil...MFA_report.pdf

    Interpretation Guide;
    http://www.genovadiagnostics.com/fil...nterpGuide.pdf

    /
    ============================== ============================== ====
    Matrix journal

    Explanation of codes posted by HAN.
    have it with you always when in doctor's office.

    Jan's BloodTest April13/2007
    ---------------------------------------------------------------------

    244.9 ========== Unspecified acquired hypothyroidism
    250.0 ========== Diabetes mellitus without mention of complication
    253.2 ========== Panhypopituitarism
    255.5 ========== Other adrenal hypofunction
    257.0 ========== Testicular hyperfunction
    259.9 ========== Unspecified endocrine disorder
    272.0 ========== Pure hypercholesterolemia
    275.1 ========== Disorders of copper metabolism
    440.0 ========== Atherosclerosis
    600.0 ========== Hyperplasia of prostate
    611.1 ========== Hypertrophy of breast
    799.81 ========== Decreased libido

    http://forum.bodybuilding.com/showth...hp?t=116624451
    ============================== ====================

    http://www.icd9data.com/2007/Volume1/default.htm
    Unspecified acquired hypothyroidism ========== 244.9 ========== Unspecified acquired hypothyroidism
    Diabetes mellitus without mention of complication ========== 250,0 ========== http://www.icd9data.com/2007/Volume1.../250/250.0.htm
    Panhypopituitarism ========== 253.2 ========== http://www.icd9data.com/2007/Volume1.../253/253.2.htm
    Other adrenal hypofunction ========== 255.5 ========== http://www.icd9data.com/2007/Volume1.../255/255.5.htm
    Testicular hyperfunction ========== 257 ========== http://www.icd9data.com/2007/Volume1.../257/257.0.htm
    Unspecified endocrine disorder ========== 259.9 ========== http://www.icd9data.com/2007/Volume1.../259/259.9.htm
    Pure hypercholesterolemia ========== 272 ========== http://www.icd9data.com/2007/Volume1.../272/272.0.htm
    Disorders of copper metabolism ========== 275.1 ========== http://www.icd9data.com/2007/Volume1.../275/275.1.htm
    Atherosclerosis ========== 440 ========== http://www.icd9data.com/2007/Volume1...48/440/440.htm
    Hyperplasia of prostate ========== 600 ========== http://www.icd9data.com/2007/Volume1...08/600/600.htm
    Hypertrophy of breast ========== 611.1 ========== http://www.icd9data.com/2007/Volume1.../611/611.1.htm
    Decreased libido ========== 799.81 ========== http://www.icd9data.com/2007/Volume1...799/799.81.htm

    =======================
    When ordering HCG

    ICD-9 608.3 Atrophy of testis
    Of note, it is also cleared for treatment of secondary hypogonadism.
    http://musc lechatroom.com/forum/showpost.php?p=78139&postcount =222
    =========================
  5. Professional Member
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    Hardasnails notes of dr Marianco's posts.
    first posted here:
    Avoiding excess conversion of testosterone into estradiol during testosterone treatme
    .
    .
    Attached Files Attached Files
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    Quote Originally Posted by JanSz View Post
    Hardasnails notes of dr Marianco's posts.
    first posted here:
    Avoiding excess conversion of testosterone into estradiol during testosterone treatme
    .
    .
    This should be a sticky !!
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    The Durk Pearson & Sandy Shaw® Life Extension News July 2004

    Excess amounts of prolactin could also be a hazard because prolactin is known to play a major role in the growth of certain tissues (breast, prostate4).


    ---------------------------------------------------------
    June 1999 Le Magazine: In The News: Elevated Prolactin Linked To Breast Cancer




    LE Magazine June 1999
    Late-breaking brief news items to life extensionists, as well as anyone interested in living a longer healthier life.

    In The News


    Elevated Prolactin Linked
    To Breast Cancer


    In last month's issue of Life Extension magazine, we repeated our recommendation that prostate cancer patients should have there prolactin blood levels checked, as excess amounts of this hormone can promote prostate cancer cell proliferation and prevent successful treatment.

    A new study indicates that high levels of prolactin predispose healthy women to an increased risk of breast cancer. Prolactin is produced by the pituitary gland and, along with other hormones, stimulates the growth of the mammary glands and the production of milk after childbirth.

    Postmenopausal women who had blood prolactin levels in the upper 25% of the reference range had about twice the risk of breast cancer compared with those in the lower 25% of the distribution, according to a report in the April 7th issue of the Journal of the National Cancer Institute.

    The size of this association is similar to that observed between breast cancer and estrogen levels, report Dr. Susan E. Hankinson of Harvard Medical School in Boston, Massachusetts, and colleagues. The study included 306 women who were healthy at the time blood samples were obtained, but went on to develop cancer. Those women were compared with 448 healthy women who did not develop cancer. This new analysis is part of the ongoing Nurses' Health Study, the largest ongoing study of women's health in human history.

    There are similarities to breast and prostate cancer cells, and prolactin seems to be a common growth factor in these two cancers. Based on the new report showing that women with high levels of prolactin have twice the risk of breast cancer, it would appear prudent for healthy women to lower their prolactin levels. Here are the standard laboratory reference ranges for blood prolactin levels:

    Female
    - Non-pregnant 2.8 to 29.2 ng/ml
    - Pregnant 9.7 to 208.5 ng/ml
    - Postmenopausal 1.8 to 20.3 ng/ml

    Male
    - 2.1 to 17.7 ng/ml

    Evidently, prolactin levels have a very wide range that conventional doctors would consider "normal." The problem is that few doctors are aware of the dangers of elevated prolactin, and if their healthy patients are in the high "normal" range, they would do nothing to treat this condition. A "normal" range often means a person has a "normal" risk for contracting a disease. Since members of The Life Extension Foundation don't want to have "normal" risk factors, here are some guidelines for those to follow who care about optimal health:

    Healthy Female
    - Non-pregnant - Prolactin level no higher than 7.3 ng/ml
    - Postmenopausal - Prolactin level no higher than 5.0 ng/ml

    Female - Breast Cancer Patient
    - Prolactin level no higher than 1.8


    Male - Prostate Cancer Patient
    - Prolactin level no higher than 2.0
    There are three FDA-approved drugs that suppress prolactin secretion. If a blood test reveals prolactin levels are elevated, ask your doctor to prescribe one of the following drugs:

    - Bromocriptine (2.5 mg one or more times a day)
    - Pergolide (.25 mg to .50 mg twice a day)
    - Dostinex (.5 mg twice a week)

    Check prolactin levels again in 30 days to make sure the drug you choose is suppressing prolactin release from the pituitary gland into the blood.

    Dostinex is the newest and cleanest drug to use. Dostinex has fewer side effects than the older drugs, is more effective in suppressing prolactin than the older drugs, and requires only twice a week dosing. It should be noted that Durk Pearson and Sandy Shaw recommended bromocriptine as a prolactin suppressing agent back in 1982, and the FDA spent millions of taxpayer dollars keeping Americans from accessing this drug for the purpose of disease prevention. Since 1982, about 700,000 American women have died of breast cancer.
    ============================== ============================== =======
    ============================== ============================== =======
    Posted by cpeil2
    Lab Results In, Need Help

    More info: pergolide has been voluntarily withdrawn from the market.


    Also re: Dostinex - the risk of valve disease is considerably lower in those taking to lower prolactin because the typical dose is much lower.
    ============================== ==

    Yes, good news. The dose for pituitary problems is so much lower than for Parkinson's that the risk of heart problems appears negligible.


    Bromocriptine - There have been isolated reports of valve disease after long-term use for Parkinson's. Again, though, it appears that the risk is dose-related
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    according to shippens chart my free t was 80 or 275ish...what would that be...good, bad???

    phats
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    Quote Originally Posted by phatkid77 View Post
    according to shippens chart my free t was 80 or 275ish...what would that be...good, bad???

    phats
    Post SHBG, specify units
    Post TotalT, specify units
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    shbg 28nmol
    total t-11.4 nmol/L
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    My little Adrenals study posted here:

    http://forum.mesomorphosis.com/554378-post13.html

    ===========================
    Summary,
    when testing Adrenals ask for following Quest tests

    Sodium
    Potassium
    Cortisol not sure yet which one, so many tests but noted that AM/PM is not available from Nichols Institute, probably of low value.
    The VA location have 2,3,4,5,6 specimens, possibly those.
    http://cas2.questdiagnostics.com/scr...&tmradio=title

    http://cas2.questdiagnostics.com/scr...SearchString2=

    Aldosterone, LC/MS/MS, Serum http://cas2.questdiagnostics.com/scr...&tmradio=title
    Aldosterone, 24-Hour Urine (19552X) - (7062N) http://cas2.questdiagnostics.com/scr...&tmradio=title
    Aldosterone (LC/MS/MS)/Plasma Renin Activity Ratio - (11183Z) http://cas2.questdiagnostics.com/scr...&tmradio=title
    Plasma Renin Activity (10537X) Code: 10537N http://cas2.questdiagnostics.com/scr...&tmradio=title
    ============================== ============================== ============================== ====================
    http://www.endocrine.niddk.nih.gov/p...on/addison.htm
    Addison's disease
    Causes
    Symptoms
    Diagnosis
    Other Tests
    Treatment
    Special Problems
    Patient Education
    For More Information
    =========================
    ========
    http://www.endocrine.niddk.nih.gov/info/index.htm

    Information About Endocrine and Metabolic Diseases
    Acromegaly
    Addison’s Disease
    Cushing’s Syndrome
    Cystic Fibrosis (from NHLBI)
    Endocrine and Metabolic Diseases Organizations
    Graves’ Disease
    Human Growth Hormone and Creutzfeldt-Jakob Disease
    Hyperparathyroidism
    Hyperthyroidism
    Hypothyroidism
    Multiple Endocrine Neoplasia Type 1
    National Hormone and Pituitary Program: Information for People Treated with Human Growth Hormone (Comprehensive Report)
    National Hormone and Pituitary Program: Information for People Treated with Human Growth Hormone (Summary)
    Organizations, Directory of
    Pregnancy and Thyroid Disease
    Prolactinoma
    Turner Syndrome (from NHGRI)
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    Copied from:
    What is considered high levels of prolactin?

    Quote Originally Posted by JanSz View Post
    Prolactin secretion is stimulated by sleep, stress (physical and emotional), and the hypothalmic hormone (TRH). Prolactin secretion is decreased by dopamine analogs such as bromocriptine.
    Hypersecretion of prolactin can be caused by pituitary tumors, hypothalmic disease, breast or chest wall stimulation, hypothyroidism, renal failure, acute excercise, stress, eating, and several medications(eg; pheno-thiazines, metoclopramide). Hyper-prolactinemia inhibits gonadothropin secretion and can produce hypogonadism in men and women with accompanying low or inapropriedly "low normal" LH and FSH levels.

    Quest Diagnostics
    EndoManual_3rdEd_2004 page 311

    Prolactin have no known role in male. page 205


    Quote Originally Posted by Dr. John View Post
    Eating, or having sex, can bring PRL to 30. Did you eat within two hours of the draw? How does midrange PRL look now?

    PRL of 300 (!) is pathognomic of a pituitary tumor.

    I hope this FINALLY gives you guys some perspective. Some of this stuff gets just plain silly: manipulating hormones for no reason whatsoever, when they are well within healthy level. Any time you alter a hormone, you are asking for trouble. THAT is how Interventional Endocrinology should be viewed.
    My take home message:
    as long as Prolactin is within range it should be ignored and not manipulated.

    If it is within range then: Prolactin have no known role in male. and that includes effects on sex.

    This message is copied to my diary as my current view on Prolactin.

    Thank you Dr John for your persistence thru many posts when holding your view on Prolactin.
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    What I have learned about TRT (under construction)

    When on TRT your goal is to keep your FreeT in upper range but not over it.
    FreeT tests are unreliable, possibly except at Quest Diagnostics and only the one that is on my list of blood tests, post #44
    If you have that test available, look also at BAT level, keep it in upper range.

    Other choice (supposedly used by Dr Shippen) is to use a chart, post #41
    On that chart desirable range is (160-250), 100 being really the lowest with any hope.

    FreeT level depends on
    Total Testosterone
    and
    SHBG
    and Albumin to some extent, we are not going to worry too much about Albumin.

    Total Testosterone depends on
    testicles production
    and
    Testosterone injections ( I consider transdermals as rather overly variable specially since many people have some or heavy thyroid problems)

    Testicles may be able to produce T (Secondary) or not (Primary)
    Testicles that are able to produce but do not have enough signal (LH, FSH) are induced to production by using HCG.
    Use of HCG while on T is always recomended because it keeps testicles full (otherwise they will shrink).
    Sometimes HCG may be used as sole TRT, but it rarely works.
    Ideal dose of HCG is 100-250iu daily, not practical.
    Someone who likes to keep their sperm fertile should probably use E2D, every two days schedule, 250iu-dose.
    If fertility is or is not at issue E3D schedule is also acceptable, every three days, 500iu-dose.
    Someone who is not able to get HCG should not worry too much, yes his testicles will shrink and stop any production.
    Testicles can be brought back to size latter on when HCG became available, not sure about fertility.
    When fertility is at issue (in the worst way), use daily (hcg-100iu and HMG-75iu) for three months to a year while trying to conceive.

    When there is a need for testosterone injections use cypionate or enanthate.
    Assuming that testcles are absent or adding (some) correction when indigenous production is known, preliminary dose of testosterone can be

    calculated
    when SHBG and last Total T is known.
    Use chart post #41, and table post #40
    table gives weekly dose (XXX mg/week)
    that dose have to be converted to volume, cc or/and units (on insuline syringe)
    Density of testosterone need to be known. Most often 200mg/mL is used but also 100mg/mL is available.
    Weekly volume need to be converted to a volume for each shot for E2D or E3D routine of injections.
    I do not consider weekly or less often injections, specially for those with low SHBG since the TT variability is a frequent source of emotional stress.
    Example,
    calculate size of individual shot
    weekly dose 130mg
    200mg/mL testosterone density
    E3D routine
    (130mg)/(200mg/mL)=0.65mL/week
    0.65mL/week=0.65cc/week=65 units/week
    65/7*3=27.9~28 units each shot

    E2D or E3D routines that is a lots of shots, specially when considering large needles that are customarily used.
    Also with large needles injections are very quick causing additional tissue damage and pain lasting sometime days.
    For this and other reasons I prefer SubQ shots around navel using smallest available needle.
    It takes 4 minutes to get the testosterone into syringe and then a minute to inject it in.
    I consider that time well spend, any sorenes last no more than 10 minutes after the shot.
    I curently use 5/16" long needle, but am considering change to 1/2" long since tiny bit of oil escapes after about every other shot.
    Not sure if it is worth the effort since going to 1/2"long needle would mean also going to thicker (39ga) needle.
    There are at least two suitable types of syringes available for purchase:
    http://hocks.com/Merchant2/merchant....Category_Code=
    BD Ultrafine II U-100 Insulin Syringe 31 Gauge 3/10cc 5/16inch Short Needle--1/2 Unit Markings 100/b Price: $25.95
    and
    http://hocks.com/Merchant2/merchant....Category_Code=
    BD Pen Needle Short 31 Gauge 3/16inch 100/box

    Bottom line, E3D routine
    both T&hcg shots on same day, then two days free of shots
    --------------------------------------------------------------------------------------------------
    While on TRT estrogens have to be monitored, all estrogens, as in blood test list post #44
    I use LEF life Extension Foundation products
    DualAction 5 pills ( for cruciferous, I3C & DIM content)
    TMG 2 pills

    I also use Arimidex or actually the liquid version for ease of use.
    I use insuline syringe with cut off needle to get my dose.
    I use Arimidex on E3D schedule, same as my T&hcg for simplicity.
    I use 0.5cc=50units=1/2pill eact time, dosing must be verified by testing.

    ------------------------------------------------------------------------------------------------
    I do blood tests once/year per my list, post #44
    also 2-4 tests thruout the year on as need basis.
    Full test is fully paid by my insurance (Medicare) when supported bt ICD-9 codes (provided in post #41)
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    Quote Originally Posted by JanSz View Post
    I consider transdermals as rather overly variable specially since many people have some or heavy thyroid problems)
    But many professionals in the field consider them a first-line option, and many man who use them are entirely satisfied with the result. Our own Dr. Crisler believes that TD's are preferable to injections because they mimic normal physiology more closely than injections.


    Quote Originally Posted by JanSz View Post
    Sometimes HCG may be used as sole TRT, but it rarely works.
    hCG can produce a good result in properly selected individuals. It is best-suited to men in early middle age having relatively modest secondary hypogonadism.
  15. Professional Member
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    Dr Marianco on low SHBG
    Attached Files Attached Files
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    --------------http://anabolicminds.com/forum/962870-post13.html

    estrone to e2 convresion

    Quote Originally Posted by RPHMark View Post
    I forget people outside pharmacy don't always know RPh is the designation for registered pharmacist. I do quite a bit of compounding bio-identical HRT (mostly for women). Obviously, I don't know their case details, but many women present with anxiety/panic attack type symptoms (who have previously never had them) duing the peri-menopausal timeframe. Normally this is due to a drop in progesterone/estrogen dominance and normally associated neurotransmitter levels falling. As you probably know heart racing, breathing problemss, and chest pain are common with this, so maybe that could be what is going on. This would not likely show up on any of the typical ER labs either. Many drs won't test actual hormone levels. We all know this should be standard practice, but it is not. Many will test LH/FSH and say they are "fine", but those levels don't generally change much duing peri-menopause as progesterone is the primary problem. To find a good HRT dr. work backwards. Go to a compounding pharmacy with a good reputation and ask them what dr to see. You can go through a group called IACP (International Acadamy of compounding pharmacists) to find a compounding pharmacy.
    Compounding Pharmacist Locator
    International Academy of Compounding Pharmacists:

    International Academy of Compounding Pharmacists: Home

    If you are unable to locate a compounding pharmacist within a 100 miles radius, please contact our toll-free referral line at 800-927-4227.
    ============================== =================
    The Medicine Shoppe
    146 Us Highway 206
    Andover, NJ 07821-4518
    (973) 786-5300
    Henry Gialanella
    146 Main St

    20 miles from ZIP 07054
    Company Name The Alchemist Shoppe
    Pharmacist Linda Witzal R.Ph.
    Address 3175 Route 10 E.
    Denville NJ 07834
    Phone (973) 328-4477
    URL scream and cream alchemist chris at alchemistshoppe.com
    Distance Approx. 5 Miles

    Company Name Pharmacy Creations

    Pharmacist Scott Karolchyk "R.Ph., FIACP"
    Address 540 Route 10 West
    Randolph NJ 07869
    Phone (973) 328-8756
    URL Pharmacy Creations News Items
    Distance Approx. 8 Miles



    Company Name Pompton Pharmacy

    Pharmacist David Stahlberger "R.Ph., FIACP"
    Address 558 Newark Pompton Turnpike
    Pompton Plains NJ 07444
    Phone (973) 839-4200
    Distance Approx. 9 Miles



    Company Name Sheefa Pharmacy & Wellness Center
    Pharmacist Ashraf Latif R.Ph.
    Address 405 Central Avenue
    East Orange NJ 07018
    Phone (973) 673-6800
    URL Welcome To Sheefa Pharmacy
    Distance Approx. 11 Miles



    Company Name Clifton Pharmacy & Compounding
    Pharmacist Howard Bleznick R.Ph.
    Address 595 Van Houten Avenue
    Clifton NJ 07013
    Phone (973) 777-2428
    Distance Approx. 12 Miles


    Company Name Medicine Shoppe
    Pharmacist Jillian Hocking Pharm. D.
    Address 36-A Main Street
    Bloomingdale NJ 07403
    Phone (973) 838-0909
    Distance Approx. 12 Miles


    Company Name Medicine Shoppe
    Pharmacist Daniel Albizati R.Ph.
    Address 559 Franklin Avenue
    Nutley NJ 07110
    Phone (973) 235-0909
    Distance Approx. 13 Miles



    Company Name Belvidere Pharmacy
    Pharmacist George Grumet R.Ph.
    Address 349 Somerset Street
    North Plainfield NJ 07060
    Phone (800) 322-1302
    Distance Approx. 15 Miles



    Company Name Millers of Wyckoff
    Pharmacist David Miller R.Ph.
    Address 678 Wyckoff Avenue
    Wyckoff NJ 07481
    Phone (201) 891-3333
    URL Millers Pharmacy
    Distance Approx. 15 Miles



    Company Name Belvidere Pharmacy

    Pharmacist Shara Rudner "R.Ph., FIACP"
    Address 349 Somerset Street
    North Plainfield NJ 07060
    Phone (908) 756-6695
    Distance Approx. 15 Miles



    Company Name Rock Ridge Pharmacy

    Pharmacist Matthew Kopacki "R.Ph., FIACP"
    Address 191 Rock Road
    Glen Rock NJ 07452
    Phone (201) 444-4190
    Distance Approx. 16 Miles


    Company Name Town & Country Pharmacy

    Pharmacist John Herr "R.Ph., FIACP"
    Address 60 E. Ridgewood Ave.
    Ridgewood NJ 07450
    Phone (201) 447-2020
    Distance Approx. 17 Miles

    ============================== ============================== =======================

    Company Name Dorneyville Pharmacy

    Pharmacist Tom Silvonek "R.Ph., FIACP"
    Address 3330 Hamilton Blvd.
    Allentown PA 18103
    Phone (800) 850-2196
    Distance Approx. 2 Miles



    Company Name "Hartzell's Pharmacy, Inc. Home Heal"
    Pharmacist Robert Hartzell R.Ph.
    Address 300 American Street
    Catasauqua PA 18032
    Phone (610) 264-5471
    Distance Approx. 3 Miles



    Company Name DelPrete's Pharmacy
    Pharmacist Keith Delprete R.Ph.
    Address 3437 Rt. 309
    Orefield PA 18069
    Phone (610) 395-2602
    Distance Approx. 7 Miles



    Company Name Medicine Shoppe
    Pharmacist Phillip Bennett R.Ph.
    Address 1408-2 W. Broad Street
    Quakertown PA 18951
    Phone (215) 536-5595
    Distance Approx. 12 Miles



    Company Name Professional Pharmacy
    Pharmacist David Stone Pharm.D.
    Address 931 Main Street
    Pennsburg PA 18073
    Phone (215) 679-9700
    Distance Approx. 14 Miles

    ============================== ============================== ===============

    also

    American Osteopathic Association

    and

    American Osteopathic Association

    Find an Osteopath : General Osteopathic Council

    healthfinder.gov - Osteopath

    Stop The Thyroid Madness » ADRENALS FAQ–the most frequently asked questions

    Stop The Thyroid Madness » How to find a GOOD DOC

    Thyroid Disease Information Source -- Bestselling Books, News, Information on Living Well With Hypothyroidism, Autoimmune Disease, Thyroid Diet, Home Page of Mary Shomon

    Physician that use ArmourThyroid
    ============================== ============================== =====================
    Quote Originally Posted by RPHMark View Post
    You have some great pharmacists in your area. Scott Karolchyk, Matt Kopacki, and John Herr are ones I have spoken with at conferences before and all of them really know their stuff. Any of the ones with FIACP after their names are fellows in IACP which is an accomplishment.
    ============================== ==
    ============================== ============================== =======================
    The World Health Network - Anti-Aging and Longevity
    look under directory
    ============================== ============================== =================
    ============================== ===
    ---------------------------------------------
    Aleksandr Martirosov, DO
    31-00 Broadway
    Fair Lawn, New Jersey 07410
    (210) 475-5006
    aleksandrmartirosov@yahoo.com
    ---------
    Family Medicine
    Addiction Medicine
    Anti-Aging Medicine
    Ostheophatic Medicine
    ---------------------------------------------
    Forward J Brent MD
    195 US Hwy 46
    Mine Hill, NJ 07803-3163
    (973)366-8884
    ------------------------
    Patrick Barrett DO
    (631)472-6000
    4568 Sunrise Hwy Oakdale, NY 11769-1012
    in case I need new doc, good one to ask for reference,
    (84.8 mi – about 1 hour 42 mins (up to 2 hours 20 mins in traffic)
    he works with a lot of bodybuilders, hes a DO and hes a GP

    ------------------------
    Anti-Aging Medicine

    Jeffrey Dach MD Bio-Identical Hormone Blog

    Find a Doctor
    Anti-Aging Physicians, Clinics & Products - WorldHealth.net
    =====================
    very nice search engine:

    Integrative Medicine Physicians - American College for Advancement in Medicine
    ============================== ============

    Doctor Referral List

    http://ucprx.com/doctor_referral_list


    ........
    http://www.osteopathic.org/osteopath...s/default.aspx

    http://www.osteopathic.org/osteopath...s/default.aspx
  17. Professional Member
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    Google Help : Cheat Sheet
    Google Help : Cheat Sheet

    Google Advanced Search
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    Google Advanced Scholar Search

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    Google Help : Advanced Search

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    EDUCATIONAL THREADS
    ----------http://forums.steroid.com/forumdisplay.php?f=12]EDUCATIONAL THREADS - Anabolic Steroids - Steroid.com / Anabolic Review Forums
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    http://anabolicminds.com/forum/male-...tml#post991716

    ============================== ============================== ============
    I am posting this response here and on the thread where dr Delgado made his statement.
    Hopefully we will get some words from him.


    http://anabolicminds.com/forum/991716-post165.html
    http://anabolicminds.com/forum/991863-post166.html
    Quote Originally Posted by DrDelgado View Post
    I will also suggest that aging is going to include a decline of hormones,
    within genetic differences, expect to augment back Testosterone,
    I keep mime and my clients under doctors monitoring,
    around 1000 to 1,200 ng/ml Total T,
    and Free T at upper range of 200 to 300 (or 20 to 40 pg/mldepending on the nomenclature)
    Aldosterone is best at 10 to 40 ug/24 hr,
    IGF-1 around 250 to 400 ng/ml.
    DHT 60 to 70 ng/dl,
    DHEA 300 ug/dl,
    insulin under 5,
    SHBG 10 to 30 nmol/l,
    Estradiol 35 pg/ml,
    with about 20 (2OHE) to 1 -16aOHE.
  19. Banned
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    JansZ
    I noted that you take high dose Chrysin now via lef products.

    You jumped from 1 - 2 pills to 7 pills right in between BW?

    Take note that Chrysin might not be an effective form of T boosting or E control

    I have had discussions with Eric over at PP about this.

    They removed Chrysin and reworked Dermacrine Sustain - "Basically, we removed chrisin to make room for more resveratrol and 7,8 benzoflavone. Plus there is some research showing that high-doses of chrysin can inhibit the enzyme which converts Adione to Test (17HSD) so we removed it to make room for the more effective T boosters."

    There is also another thread floating around here that has a MD backed study showing Resveratrol to be much more superior than chrysin for controlling E.

    I would dump the product your taking and just go for straight RSV. Check out this thread, pages 3 in specific Resveratrol really cheap

    I noted that you cannot go transdermal form, so look for revgentics which sells massive doses of RSV, specifically the X500. 500mg pure RSV. Cut pill in half
  20. Professional Member
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    Quote Originally Posted by plymouth city View Post
    JansZ
    I noted that you take high dose Chrysin now via lef products.

    You jumped from 1 - 2 pills to 7 pills right in between BW?

    Take note that Chrysin might not be an effective form of T boosting or E control

    I have had discussions with Eric over at PP about this.

    They removed Chrysin and reworked Dermacrine Sustain - "Basically, we removed chrisin to make room for more resveratrol and 7,8 benzoflavone. Plus there is some research showing that high-doses of chrysin can inhibit the enzyme which converts Adione to Test (17HSD) so we removed it to make room for the more effective T boosters."

    There is also another thread floating around here that has a MD backed study showing Resveratrol to be much more superior than chrysin for controlling E.

    I would dump the product your taking and just go for straight RSV. Check out this thread, pages 3 in specific Resveratrol really cheap

    I noted that you cannot go transdermal form, so look for revgentics which sells massive doses of RSV, specifically the X500. 500mg pure RSV. Cut pill in half
    Thanks for your concern.
    I stopped using Chrysin over two moths ago.
    Looking at my April's test, I came to conclussion that I should reduce pressure on my SHBG.
    Specially that I am aiming at TotalT~(1100-1200) and FreeT~300 per Nick Delgado rather than previous FreeT~250 per dr Shippen.
    There is two SHBG positions on that test, 20 and 24.
    I was getting Chrysin from LEF's
    Super MiraForte with Maximum Strength Chrysin
    Super Miraforte With Max Strength Chrysin, 120 Caps
    that product contains Nettle (Urtica dioica) which lowers SHBG.

    I also take 200mg resveratrol, separately, this is on top of resveratrol that I am getting with DualAction.

    When I changed from Tcream to Deopo-Testosterone shots on june 19/2007 I added Liquidex 0.5cc with each shot, I use E3D schedule.
    =====================
    I had doctor visit tonight.
    I will be doing Metabolic Analysis Profile.
    Genova Diagnostics

    I have seen (partial) results from my last blood test.
    Pregnenolone is on the bottom of range
    I am increasing from 1gram to 2 grams preg cream

    DHEAs is below range, I will start using DHEA again, probably 100mg

    Do not know what to think (could use help) about my (blood serum) Aldosterone=1.0ng/dL(<or=28)
    In April it was=4
    Quest Diagnostics: Test Menu

    I thought that Aldosterone should be in high teens or even 20's

    Should I reduce salt, increase Potassium, what to do???
    Lately I use more salt then I used to use in my life (taste good, not sure if I need the salt).
    ----
    Note on Quest web site.
    Because
    serum aldosterone concentrations vary due to dietary sodium
    intake and body position, some physicians prefer
    measurement of 24-hour urine concentrations for
    aldosterone.
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    I wouldn't sweat the aldosterone reading.

    Unless I see low aldo confirmed by urinary analysis I don't buy much into it.

    Your DHEA and Preg both went down.

    Want to bet that your TT is sky high right now, way above the 4 something range it was before?

    This is common for other androgenic hormones to crash when exogenous T is administered. By knowing that, Im betting 10 -1 your shots are working.

    Im not a fan of oral DHEA.

    Get some Dermacrine JansZ. I think they have a superior delivery system than the usual preg compounded cream you get from a script, plus the added bonus of DHEA transdermal. Start at half dose. Plus added resveratrol and benzoflavone 7,8 in it.

    Where do you get resveratrol( you netioned 200mg a day) LEF is way to expensive. Check my "resveratrol really cheap" post, I like revegentics for pure RSV, the X500, VERY cheap.
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    Ok, so I have my blood test result from 8/30/07 blood draw.
    They shorted me on
    Testosterone, Free, Bio/Total (LC/MS/MS)
    Dihydrotestosterone, Free, Serum (36168X)
    so next script is on a way and I will have to get poked again.

    There is two Estrodial results, from description I thought that both were ultrasensitive, but I got different results.
    I am going with the one that comes with FreeE2
    My freeE2 is high, (but my pines is working ok).
    I am incresing Liquidex from 0.5 to 0.6cc E3D
    so my weekly dose is now
    0.6*7/3=1.4cc/week
    increase from
    0.5*7/3=1.17cc/week

    my Fibrinogen=424(175-425)
    LEF wants (180-250)
    I asked doc for TRENTAL®
    (pentoxifylline)
    Tablets, 400 mg
    1 or 2 tablets daily
    will see what comes out of this request

    FreeT3 freeT4
    9/16/07 I upped Armour from 3grains to 3.5
    also asked for script for Synthroid 25mcg, I will use 1pill/day.

    9/20/07 Changed back to 3grains plus 2pills Synthroid 25mcg.
    Hopefuly my body can convert some T4-->T3 and I raise both FreeT4 and FreeT3
    will be watching pulse and temps.
    ---------
    Pregnenolone/DHEA

    I upped preg cream from one to 2grams/day
    Started on DHEA, 100mg/day

    ----------------------------
    Genova Diagnostics
    EstroEssence
    and

    Metabolic Analysis Profile and Cellular Energy Profile
    out for testing
    Monday Oct1/2007

    ============================== ============================== ============
    Oct1/2007
    finaly received testosterone results (after second poking), they still omitted DHT.
    .
    68 Testosterone, Free, Bio/Total (LC/MS/MS) Quest Diagnostics: Test Menu
    69 /------------------------------------ 1151 (250-1100) ng/dL Testosterone Total
    70 /------------------------------------ 248.5 (46-224) pg/mL Testosterone Free
    71 /------------------------------------ 456.9 (110-575) ng/dL Testosterone Bioavailable
    72 /------------------------------------ 26 (17-54) nmol/L SHBG
    73 /------------------------------------ 4.0 (3.6-5.1) g/dL Albumin, serum
    74 Dihydrotestosterone, Free, Serum (36168X) --------- Quest Diagnostics: Test Menu
    75 /------------------------------------ 69 (25-75 ) ng/dL Dihydrotestosterone
    76 /------------------------------------ 7.52 (1.00-6.20) pg/mL Dihydrotestosterone, FREE
    77 /------------------------------------ 1.09% (0.62-1.10) % Dihydrotestosterone, FREE %




    ------
    My goal
    FreeT~300, =(248.5-46)/(300-46)=0.7972 (dose is short 20%)
    BAT~575 (top range), =(456.9-110)/(575-110)=0.7460 (dose is short 25%)

    730 740 750 760 770 780 790 800 810 820 830 840 850 860 870 880 890 900 910
    449 454 459 463 468 473 477 482 487 491 496 501 505 510 515 519 524 529 533

    920 930 940 950 960 970 980 990 1000 101 102 103 104 105 106 107 108 109 110
    538 542 547 552 556 561 566 570 575.0 580 584 589 594 598 603 608 612 617 622



    I am still short on both
    The test represents my Depo-Tshots=30units at E3D schedule.
    My new dose should be around
    =30/0.75=40units=186.7mg/week
    =30/0.8=37.5units=175mg/week
    conservatively I make my new dose =38units=177.3mg/week
    ------
    Note1, using dr Shippen chart my FreeT=325pg/mL
    Note2, using (totally unreliable BAT)(but FreeT sort of close)
    Free & Bioavailable Testosterone calculator

    FreeT=343 pg/mL
    BAT=750ng/dL
    .
    Note3, the 31GA 5/16"long leaked out little bit of oil, changed (over month ago) to 30Ga 1/2"Long
    .
    .
    .............................. .............................. .................


    they have Novarel.
    No Novarel
    -----------------------------------------------------------------------
    Note, nov9/07
    For a while I have changed Novarel from 500iu on the day of T shots to 250iu on both days between T shot.
    My testicles are little firmer, scrotum hangs low more often.
    Since now I am doing shots every day, I decided to do T shots E2D and 250iu in beween.
    Testosterone was 38units now 38/3*2=25.33~ 25.5units
    38*7/3=


    my weekly dose is:
    =0.255*200*7/2=178.5mg/week

    my old weekly dose, the one corresponding to current test results was 0.3*7/3*200=140
    I expect that my BAT should raise to 456.9*178.5/140=583
    actually even more because blood was drawn on third day, but now it will be drawn on second day after T shot.

    Liquidex on days of T shot, 0.6/3*2=0.4cc
    Dec6/07
    Started Anastrozole from ChemOne Research it is sweet and do not sting, wonder if will work.
    Dark in color, hard to see numbers on syringe.
    Some morning wood problems, decreasing dose to 0.36=36units
    0.36*7/2=1.295cc/week Arimidex pills/week
    Dec20/07
    EstroEssence from Dec13/07 shows low urine E2
    Change Anastrozole to 0.33*7/2=1.155cc/week

    Feb29/08
    Stopped DualAction, BreastFormula, MiraForte
    Started 2 scoops DIM-Powder
    Change Anastrozole to =0.38*7/2=1.33cc/week
    Piston on my 3/10cc syringe is 6 units high, top of piston is at 38+6=44
    Mar15/08 Anastrozole 45units (45+6=51) .45*7/2=1.575

    --------------------------------------------------------------------------------)



    My E2 story


    See erection weakness.
    Blood drawn 3/19/08, reported 3/31/2008
    DHT=81(25-75)
    E2=4(< or =29)
    E2, Free=.07(< or = 0.45)
    E2,%Free=1.82(1.25 - 1.85)

    Stopped Anastrozole, 3/31/08
    ---
    Pines worked best while in Atlantic City (May 25/08)
    ---
    See erection weakness
    Blood drawn 5/23/08, reported 6/4/08 (instead of 48 hrs, had to draw 24 hrs after T shot, so the TT values are little higher)

    E2D schedule, T=25.5units=178.5mg/week, HCG=500iu
    No Anastrozole since 3/31/08

    TT=1117(250-1100)
    BAT=584.6(46-575)
    FreeT=303.5(46-224)
    SHBG=18
    Albumin=4.2
    DHT=77(25-75)
    E2=39(< or =29)
    E2, Free=1.07(< or = 0.45)
    E2,%Free=2.73(1.25 - 1.85)
    Note:
    See erection weakness, but week ago was still strong.
    Most likely I feel best at E2=29
    June 10/08, restarted Anastrozole
    0.25cc/E2D=0.25*7/2=0.875/week
    about June 15 changed to 0.25cc every day

    June 26/08 first night with strong nightly wood.
    (today is my HCG day, no Anastrozole until second T shot)
    =================

    8/02/08
    Estradiol, Ultrasensitive, LMMSMS=15(<29pg/mL)
    I was using Anastrozole(liquid) before this test, now stopped completely.
    ===============

    1/6/2009
    For no particular reason I decided to change from 25units to 0.22cc=22units each T-shot.
    Mostly because my last SHBG was going down, also I am on 2 ejaculations a week, down from three.

    I plan next blood test end of Feb may be March depending how I feel.
    If I extend to April then will do long test.

    Experiments with glucose/insuline, vegetable juicing, heavy duty probiotics, enzymes, pre-biotics, chlorella,
    result with 1.5 weeks of liquid stool.
    Suspect mostly because of chlorella and change in vitC.
    Previously vitC from NowFoods now changed to LEF brand.
    LEF brand may be the real thing, 3grams/day, 2 morning, 1 evening.
    My list od supplements is now much shorter, very basic, this is in preparation for SpectraCell5000 test.
    Experiments with NutrEval indicate tremendous variations between tests.
    Hopefully will have better luck with following SpectraCell5000.

    (Loose/liquid stool) If not the above, then may be it is a comeback of lactose intolerance, as it was 2005/2006.




    ----------------------------------------------------------------------------------------------------



    Discussion with colkurtz_spf about hcg level.
    HCG not restoring ball size.
    .
    I am going back to 31ga 5/16"long needle 3/10cc
    the dose will fit in that small volume syringe
    Any leaking is small any how, 30ga 1/2"long needle also leaked sometime
    minimizing scar tissue is more important to me.
    .
    -----------------------------------------------------------------
    Located study:
    Low-Dose Human Chorionic Gonadotropin Maintains
    Intratesticular Testosterone in Normal Men with
    Testosterone-Induced Gonadotropin Suppression
    http://calendar.hsl.washington.edu/d...Dose_Human.pdf

    Study shown that:
    125, 250, or 500 IU hCG every other day

    Posttreatment
    ITT was 25% less than baseline in the 125 IU hCG group,
    7% less than baseline in the 250 IU hCG group, and
    26% greater than baseline in the 500 IU hCG group.
    ---------------------------
    I am changing my HCG dose to 110%
    my new dose of HCG=380IU=19units I dissolve hcg in 5mL Bwater.
    today 11/30/2007
    ============================== =================
    Pregnyl® 1500IU - X-PIL
    Pregnyl® 1500 I.U.
    Pregnyl comes as 2 ml ampoules of dry white powder with 1 ml ampoule of solvent.
    ============================== =================
    Pregnyl® 5000IU - X-PIL
    Pregnyl® 5000 I.U.
    Pregnyl comes as 2 ml ampoules of dry white powder with 1 ml ampoule of solvent. That is very little amount of solvent, reason not to buy it.
    ============================== =================
    Low-Dose Human Chorionic Gonadotropin Maintains Intratesticular Testosterone in Normal Men with Testosterone-Induced Gonadotropin Suppression -- Coviello et al. 90 (5): 2595 -- Journal of Clinical Endocrinology & Metabolism
    Low-Dose Human Chorionic Gonadotropin Maintains
    Intratesticular Testosterone in Normal Men with
    Testosterone-Induced Gonadotropin Suppression
    © 2005

    ============================== =========================

    ADDED 10/12/2010

    http://mus clechatroom.com/forum/showpost.php?p=115322&postcoun t=85
    Serum 17-hydroxyprogesterone strongly correlates w... [Fertil Steril. 2008] - PubMed result
    Fertil Steril. 2008 Feb;89(2):380-6. Epub 2007 Apr 26.
    ============================== ==================

    One way to use this report:
    proper levels of
    17-hydroxyprogesterone (17OH-P)
    can be manipulated by use of
    pregnenolone (first)
    and
    HCG injections (second)

    also
    measurements of 17-hydroxyprogesterone
    may tell us if we are using enough HCG.

    ////////////

    RESULT(S): With T administration alone, serum 17OH-P decreased significantly and increased significantly when 500 IU hCG was administered. End-of-treatment ITT strongly correlated with serum 17OH-P. Moreover, serum 17OH-P, but not androstenedione or DHEA, was independently associated with end-of-treatment ITT by multivariate linear regression.

    CONCLUSION(S): Serum 17OH-P is highly correlated with ITT in gonadotropin-suppressed normal men receiving T and stimulated with hCG. Serum 17OH-P is a surrogate biomarker of ITT and may be useful in research and in men receiving gonadotropin therapy for infertility.

    ////

    Group 3 (250iu)
    start-ITT=1239nmol/L
    end-ITT=1037nmol/L
    start-17-hydroxyprogesterone=4.9nmol/L
    end-17-hydroxyprogesterone=4.9nmol/L
    start-Androstenedione=6.4 (nmol/L)
    end-Androstenedione=6.6 (nmol/L)

    Group 4 (500iu)
    start-ITT=1227nmol/L
    end-ITT=1470nmol/L
    start-17-hydroxyprogesterone=4.6nmol/L
    end-17-hydroxyprogesterone=7.8nmol/L
    start-Androstenedione=6.5 (nmol/L)
    end-Androstenedione=9.5 (nmol/L)

    using Group 3 only to raise ITT to original levels requires HCG dose 250*1239/1037=299iu
    using Group 4 only to raise ITT to original levels requires HCG dose 500*1227/1470=417iu
    average(299,417)=358iu

    expect 17-hydroxyprogesterone to be at=6.3+(7.8-6.3)*(358-250)/(500-250)=6.9(nmol/L)=227.72 ng/dL

    expect Androstenedione to be at=8.4+(9.5-8.4)*(358-250)/(500-250)=8.9(nmol/L)=25.50 ng/dL












    3/16/2013


    HCG - 1000IU too much? - Page 2
    ----------------------------

    UPDATE: Very Low-Dose hCG & Intratesticular Testosterone

    UPDATE: Very Low-Dose hCG & Intratesticular Testosterone

    by Michael Scally MD





    ..........




    Serum 17-hydroxyprogesterone strongly correlat... [Fertil Steril. 2008] - PubMed - NCBI

    Serum 17-hydroxyprogesterone strongly correlates with intratesticular testosterone in gonadotropin-suppressed normal men receiving various dosages of human chorionic gonadotropin.
    Attached Images Attached Images  
  23. New Member
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    Quote Originally Posted by JanSz View Post

    my Fibrinogen=424(175-425)
    LEF wants (180-250)
    I asked doc for TRENTAL®
    (pentoxifylline)
    Tablets, 400 mg
    1 or 2 tablets daily
    will see what comes out of this request

    Curcumin is supposed to do a job on fibrinogen. Do you have any experience with it?
  24. Professional Member
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    Quote Originally Posted by cpeil2 View Post
    Curcumin is supposed to do a job on fibrinogen. Do you have any experience with it?
    I was using Curcumin for a while but then stopped, newer done blood testing.

    LEF recomends Trental. Hopefully my doc will come thru.
    I will see him in an hour. (Good doc, I am able to contact him at will, to ease up on his time, few hour ago I send e-mail with my requests ).

    Inflammation (Chronic) - Print Version : Online Reference For Health Concerns

    Ok, Synthroid 25mcg
    and
    Pentoxifylli 400mg
    are at home.

    I am at 3.5 grains of Armour, that should put my FreeT3 at the top range
    but my freeT4 will lag behind hence 1pill 25mcg/day of Synthroid.
    I newer tried, I may be one of the lucky guys who convert T4-->T3
    Latter may want to get down on Armour and boost up Synthroid.

    Looking for a formula on how to do it.
    Assuming 3.5 Grains of Armour and 25mcg Synthroid keep FreeT3 and FreeT4 on top.
    Assuming that I am able to fully convert T3--->T3 how (without blood testing) figure my theoretical T4 dose that I would need in the basence of Armour.
    ============================== ============================== =========
    Nov9/07 For about 3 weeks I am using 3x25mcg Levothyroxin and 3Grains Armour divided in half.

    Normally I do not use Cortef but if I feel little down, and have dancing or gym ahead, I take one 5mg Cortef 2-3 hours before, sometimes another Cortef before I start dancing and feel much better and have better stamina.
  25. New Member
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    Quote Originally Posted by JanSz View Post

    What is the cheapest injectible fertility drug you can buy in the US?
    Question:
    What is the cheapest injectible fertility drug you can buy in the US? I have heard of quite a few different injectible drugs you can use (i.e., Pergonal, HMG, Humegon, etc) and want to know if there is a drug that is cheaper than the others and also is it effective?
    I recognize most of the drugs listed here as female fertility drugs. Do they also work to increase fertility in males?
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    HCG works like LH (Luteinizing Hormone). LH in men controls testosterone release.

    HMG works like FSH (Follicular Stimulating Hormone). FSH in men triggers sperm production.

    There's less difference between male and female systems than you might think!

    Mark
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    Quote Originally Posted by MarkLA View Post
    HCG works like LH (Luteinizing Hormone). LH in men controls testosterone release.

    HMG works like FSH (Follicular Stimulating Hormone). FSH in men triggers sperm production.

    There's less difference between male and female systems than you might think!
    That's very interesting. Which one does Clomid work on, FSH, right? My doctor says that boosting my clomid won't have any effect but I'm not sure about that.

    It sounds like what I need is the hCG, which is an IM injection, correct?
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    Quote Originally Posted by hardasnails1973 View Post
    Jansz your going taking 3 steps backwards and one forward.
    what is dosage of testosterone you are taking every 3 days?
    The dosages you are doing are crossing the benefit/risk ratio of TRT and are headed into steroid usage which will only put stress on entire endocrine system and will feel good for 2-3 weeks untill your testosterone and estrogen receptors are over loaded and then you will crash. Been there did that done that. Your adrenals are already stress and adjusting your testosterone dosge to 800-900 on blood test on second day after the injection will give you a good average. Your e2 and DHT are going to go out the roof and like Dr Shippen told me using another drug inorder to offset side effects to push above the numbers all the way to high end is fuked up.

    Think of it this way
    bypossible swtiching over to hcg +injections and keeping them in upper 25% of the range you will lower dht and e2 which will reduce the need for finisterde and armidex. More is not better Bro and personally you are going to end up causing major cardiovascaular problems in the future tinkering around with those dosages. Go 42.5 mgs every 3 days with 250 ius retest in 4 weeks then increase if not into target range

    hardasnails

    i was wondering if you are a dr?also wondering where you get the basis for over 800-900 t level is unsafe. not breaking stones...just trying to understand.

    bodybuilders regularly have t levels of double or triple that and when on much higher.

    do you have any links / research that support what you are saying?

    bob
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    Jan....thanks fo the B12 info

    Hardasnails....bump on the t question

    Bob
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    rT3 high, how to deal with it


    Use thise three Genova diagnostics tests.

    Comprehensive Thyroid Assesment
    Oxidative Stress Panel (part of NutrEval)
    Elemental Analysis, Packed Erythrocytes (RBC's)(part of NutrEval)


    Read results, follow advice given by those tests.

    So really best would be to use two tests (few extra $$ but lots of informations):
    NutrEval
    Comprehensive Thyroid Assesment
    ---------------------------------------------------------------------------
    -------------------
    -------------------

    High rT3
    5' deiodinase (Se dependent)
    ----------------------------------------------------------
    Selenium also performs other important roles in the body.
    The most important of these is probably as its role as the body's best antioxidant (anti-peroxidant).
    It performs this role as part of glutathione peroxidase (GSHPx or GPX).

    Glutathione Peroxidase (GSH-Px)
    Glutathione peroxidase is a selenium-dependant enzyme found primarily in the cytoplasm (70%) but also in the mitochondria (30%).
    -----------------------------------------------------------------
    Genova Diagnostics' Oxidative Stress Panel
    checks Glutathione Peroxidase
    -----------------------------------------------------------------

    Interactions, (close): (iodine, selenium, zinc, copper)
    ie; at least above four have to be in proper balance
    ---------------------------------------------------------------------------------------------------
    Genova Diagnostics' Elemental Analysis, Packed Erythrocytes (RBC's)
    checks (it is missing iodine):
    TOXICS
    Antimony
    Arsenic
    Cadmium
    Lead
    Mercury
    Thallium
    Tin

    NUTRIENTS
    Chromium
    Copper
    Magnesium
    Manganese
    Potassium
    Selenium
    Vanadium
    Zinc

    ---------------------------------------------------------------------------------------------------
    If the above investigations falls short, further investigations should be made looking into:
    Interactions, (wide range)
    Ag, Co, Cr, Fe, Hg, I,Rb, Sb, Sc, Se, Zn



    -------------------------------------------------------------------------------------------------------------------------------
    http://www.ithyroid.com/iodine.htm
    While I've found research on the interactions of iodine and selenium, there are two other minerals which need to be studied for their interactions with these two: zinc and copper. I found one study which examined the complex interactions of selenium, iodine, and zinc (there are interactions), but none which have looked at all four minerals in a 4 X 4 factorial design. Now that would be an interesting study! Hopefully someone will do that soon.

    I think one lesson from studying the interactions of selenium and iodine is that the interrelationships between minerals are very complicated. Supplementing with one or two can cause further problems. You have to make sure that you correct every deficiency. Health is built from a chain of nutrients and, like a chain, health cannot be accomplished if one nutrient is missing. Sometimes it's complicated putting the chain back together without running into problems (like supplementing with either selenium or iodine, but not both), but every deficiency has to be corrected. John
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    Blood test at Quest, blood drawn 3/19/2008
    page #1 --Comp metabolic panel
    page #2 --Hepatic function panel
    page #3 --CBC w/Diff , risk factors
    page #4 --
    page #5 -- VAP Cholesterol
    Attached Images Attached Images      
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    Holy crap your iodine levels are off the chart.
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    Quote Originally Posted by JanSz View Post
    Blood test at Quest, blood drawn 3/19/2008
    page #1 --Comp metabolic panel
    page #2 --Hepatic function panel
    page #3 --CBC w/Diff , risk factors
    page #4 --
    page #5 -- VAP Cholesterol
    E2 is too low, Jan, as I am sure you realize.
  35. Professional Member
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    rT3 high, how to deal with it


    rT3 high, how to deal with it


    Use thise three Genova diagnostics tests.

    Comprehensive Thyroid Assesment
    Oxidative Stress Panel (part of NutrEval)
    Elemental Analysis, Packed Erythrocytes (RBC's)(part of NutrEval)


    Read results, follow advice given by those tests.

    So really best would be to use two tests (few extra $$ but lots of informations):
    NutrEval
    Comprehensive Thyroid Assesment
    ---------------------------------------------------------------------------
    -------------------
    -------------------

    High rT3
    5' deiodinase (Se dependent)
    ----------------------------------------------------------
    Selenium also performs other important roles in the body.
    The most important of these is probably as its role as the body's best antioxidant (anti-peroxidant).
    It performs this role as part of glutathione peroxidase (GSHPx or GPX).

    Glutathione Peroxidase (GSH-Px)
    Glutathione peroxidase is a selenium-dependant enzyme found primarily in the cytoplasm (70%) but also in the mitochondria (30%).
    -----------------------------------------------------------------
    Genova Diagnostics' Oxidative Stress Panel
    checks Glutathione Peroxidase
    -----------------------------------------------------------------

    Interactions, (close): (iodine, selenium, zinc, copper)
    ie; at least above four have to be in proper balance
    ---------------------------------------------------------------------------------------------------
    Genova Diagnostics' Elemental Analysis, Packed Erythrocytes (RBC's)
    checks (it is missing iodine):
    TOXICS
    Antimony
    Arsenic
    Cadmium
    Lead
    Mercury
    Thallium
    Tin

    NUTRIENTS
    Chromium
    Copper
    Magnesium
    Manganese
    Potassium
    Selenium
    Vanadium
    Zinc

    ---------------------------------------------------------------------------------------------------
    If the above investigations falls short, further investigations should be made looking into:
    Interactions, (wide range)
    Ag, Co, Cr, Fe, Hg, I,Rb, Sb, Sc, Se, Zn



    -------------------------------------------------------------------------------------------------------------------------------
    http://www.ithyroid.com/iodine.htm
    While I've found research on the interactions of iodine and selenium, there are two other minerals which need to be studied for their interactions with these two: zinc and copper. I found one study which examined the complex interactions of selenium, iodine, and zinc (there are interactions), but none which have looked at all four minerals in a 4 X 4 factorial design. Now that would be an interesting study! Hopefully someone will do that soon.

    I think one lesson from studying the interactions of selenium and iodine is that the interrelationships between minerals are very complicated. Supplementing with one or two can cause further problems. You have to make sure that you correct every deficiency. Health is built from a chain of nutrients and, like a chain, health cannot be accomplished if one nutrient is missing. Sometimes it's complicated putting the chain back together without running into problems (like supplementing with either selenium or iodine, but not both), but every deficiency has to be corrected. John
  36. Professional Member
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    http://www.muscle_____chat_____room....hread.php?t=18

    null good starting page

    http://www.meta-ehealth.com/site/off...yclopedia&id=6

    Nutritional Influences on Estrogen Metabolism: A Summary


    Nutritional Influences on Estrogen Metabolism: A Summary
    By Douglas C. Hall, M.D.
    Estrogen affects the growth, differentiation, and function of tissues throughout the body?not just those involved in reproduction. It plays an important role in bone health, protects the cardiovascular system, and influences behavior and mood. While appropriate levels of estrogens are essential for good health, several studies conclude that as exposure to estrogen increases, the risk of several cancers, including breast, ovary, prostate, and thyroid, also increases.1-6 Furthermore, excessive estrogen exposure can lead to other health problems such as premenstrual syndrome (PMS), endometriosis, and fibrocystic or painful breasts.

    Various lifestyle and environmental factors can influence estrogen production, metabolism, and balance. These include poor diet, obesity,excess alcohol consumption, high insulin levels, medications such as hormone replacement therapy and birth control pills, overexposure to chemicals found in pesticides and industrial chemicals, and agricultural hormones in animal products consumed by humans.2,7-11 Genetics can also play an important role in determining estrogen levels.

    The Basics of Estrogen Metabolism
    "Estrogen" is a term that is used to collectively describe the female hormones estradiol, estrone, and estriol. The most potent of these is estradiol. Estrogens circulate in the body mainly bound to the sex hormone binding globulin (SHBG) and only unbound estrogens can enter cells and cause biological effects.12,13 Therefore, any change in the concentration of SHBG will alter estrogen activity by changing the availability of estrogen to the target cell.

    The ultimate biologic effect of estrogen in the body depends on how it is metabolized. The metabolism of estrogen takes place primarily in the liver through Phase I (hydroxylation) and Phase II (methylation and glucuronidation) pathways, which allow the estrogen to be detoxified and excreted from the body.

    Hydroxylation ?Hydroxylation yields three metabolites that vary greatly in biological activity: 2-hydroxyestrone (2-OH),16-OH, or 4-OH.14 The 2-OH metabolite is generally termed the "good" estrogen because it generates very weak (and therefore potentially less harmful) estrogenic activity in the body. In contrast, the 16-OH and 4-OH metabolites show persistent estrogenic activity and may promote dangerous tissue growth.14-17 In fact, women who metabolize a larger proportion of their estrogen via the 16-OH metabolite may be at significantly greater risk of developing breast cancer.1,14-16,18,19 Therefore, shifting estrogen balance toward a less estrogenic state through promotion of the 2-OH pathway may prove very beneficial in improving a variety of conditions related to elevated or imbalanced estrogen levels.

    Methylation ?The 2-OH and 4-OH estrogen metabolites are further detoxified via a process called methylation. This is an important pathway, because it renders the harmful 4-OH metabolite significantly less active. Furthermore, if they are not methylated, the 2-OH and 4-OH estrogens can be converted to highly reactive molecules that can damage DNA.16,20,21

    Glucoronidation ?In glucoronidation, a glucuronic acid group combines with an estrogen molecule to facilitate the elimination of excess estrogen from the body.12 These actions make glucoronidation one of the key Phase II liver detoxification pathways for estrogens.

    Nutritional Support of Optimum Estrogen Metabolism
    Many elements of good nutrition and diet play an important part in influencing estrogen metabolism and detoxification. Incorporating dietary changes with the addition of beneficial nutrients and herbs can profoundly affect estrogen balance and potentially reduce the risk of estrogen-dependent cancers and other hormone-related conditions.

    Diet?It has been found that dietary interventions such as increasing consumption of cruciferous vegetables like cabbage and broccoli, and foods such as soy can significantly increase the 2-hydroxylation of estrogen. Dietary fiber intake can promote the excretion of estrogen by binding estrogens in the digestive tract and also increases serum concentrations of SHBG, thus reducing levels of free estradiol.22,23 Complex carbohydrates, such as those found in vegetables and whole grains, are more effective in optimizing estrogen metabolism than simple carbohydrates, which can detrimentally raise blood glucose levels and stimulate insulin release, resulting in secondary adverse influences on sex hormone balance.8

    Phytoestrogens?These plant compounds are similar in shape to the estrogen molecule and can bind to estrogen receptors (ERs). They are much weaker than endogenous estrogens and, through competitive inhibition, have been shown to prevent the receptor binding of "stronger," more stimulating estrogens.7,24,25 Phytoestrogens are currently under extensive investigation as a potential alternative therapy for a range of conditions associated with estrogen imbalance, including menopausal symptoms, PMS, endometriosis, prevention of breast and prostate cancer, and protection against heart disease and osteoporosis.7,25-27

    The two main classes of phytoestrogens are isoflavones and lignans. Soy is perhaps the most common food source of isoflavones, but other excellent sources include legumes, clover, and kudzu root. Higher intakes of soy products and isoflavones, such as consumed in traditional Japanese diets, are associated with low rates of hormone-dependent cancers.28 Lignans are compounds are found in fiber-rich foods such as flaxseed and other oil seeds, whole grains, legumes, and vegetables.29,30 Lignans stimulate the production of SHBG in the liver, and therefore reduce the levels of free estrogen in circulation. They also inhibit aromatase, an enzyme that synthesizes estrogen.

    Vitamin E and Magnesium?Low serum vitamin E is associated with elevated estrogen levels, and may negatively affect estrogen detoxification. Women with PMS have experienced improvements of their symptoms when given supplemental vitamin E.31 Magnesium promotes estrogen detoxification by promoting methylation and glucuronidation, key estrogen detoxification pathways. Ovarian hormones influence magnesium levels, triggering decreases at certain times during the menstrual cycle as well as altering the calcium to magnesium ratio. These cyclical changes can produce many of the well-known symptoms of PMS in women who are deficient in magnesium and/or calcium.32

    Indole-3-Carbinol (I3C)?I3C is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage that actively promotes the breakdown of estrogen via the beneficial 2-OH pathway.14,33-35 Therefore, I3C is protective to estrogen-sensitive tissues and may be beneficial to those with health issues related to excessive estrogen. Not only does I3C promote healthier estrogen metabolism, but it may also act as a "weak" or anti-estrogen in a similar fashion to isoflavones.36

    B Vitamins?Folate and vitamins B6 and B12 function as important cofactors for enzymes involved in estrogen detoxification; thus, decreased levels of B vitamins can lead to increased levels of circulating estrogens. Certain B vitamins also have the potential to modulate the biological effects of estrogen by decreasing the cell's response when estrogen binds to the ER.37 B vitamins also play a role in the prevention of cancer because they are important for DNA synthesis and repair.

    Calcium D-Glucarate?Calcium D-glucarate is a natural compound found in foods that appears to have some influence on breast cancer by aiding in detoxification and the regulation of estrogen.38,39 It has been found in animal models to lower estradiol levels and inhibit the initiation, promotion, and progression of cancer.38

    Other Beneficial Phytonutrients and Herbs
    Many other naturally occurring compounds derived from a variety of plant sources are available that promote healthy estrogen metabolism. These include curcumin, a compound found in the herb turmeric (Curcuma longa) that increases the phase II detoxification of catechol estrogens;40,41 chrysin, a bioflavonoid that inhibits aromatase activity, thus reducing the synthesis of estrogen activity;42 the herb, rosemary, which promotes the formation of the 2-OH estrogen metabolite;43 and D-limonene from citrus fruits, which promotes the detoxification of estrogen and shows promise in the prevention and treatment of breast and other cancers.44,45 Furthermore, many antioxidant nutrients and phytonutrients can reduce the oxidation of the 2-OH and 4-OH estrogen metabolites. Notable nutrients in this group include vitamin C, N-acetylcysteine, the mineral selenium, and green tea.

    In addition, traditional societies have long relied on a variety of hormone-modulating herbs in treating women's health conditions. These include black cohosh, chasteberry, ginseng, dong quai, and licorice. The mechanism of action of these herbs varies; however, many have been found to contain beneficial phytoestrogens.

    References
    Bolton JL, Pisha E, Zhang F, et al. Role of quinoids in estrogen carcinogenesis. Chem Res Toxicol 1998;11:1113-27.
    Colditz GA. Relationship between estrogen levels, use of hormone replacement therapy, and breast cancer. J Natl Cancer Inst 1998;90(11):814-23.
    Thomas HV, Reeves GK, Key TJ. Endogenous estrogen and postmenopausal breast cancer: a quantitative review. Cancer Causes Control 1997;8(6):922-28.
    Rose PG. Endometrial carcinoma. New Eng J Med 1996;335(9):640-49.
    Hankinson SE, Willett WC, Manson JE, et al. Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst 1998;90(17):1292-99.
    Zanetta GM, Webb MJ, Li H, et al. Hyperestrogenism: A relevant risk factor for the development of cancer from endometriosis. Gynecol Oncol 2000 Oct;79(1):18-22.
    Kuiper GG, Lemmen JG, Carlsson B, et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor & beta. Endocrinology 1998;139(10):4252-63.
    Kaaks R. Nutrition, hormones, and breast cancer: Is insulin the missing link? Cancer Causes Control 1996;7:605-25.
    Snedeker SM, Diaugustine RP. Hormonal and environmental factors affecting cell proliferation and neoplasia in the mammary gland. Prog Clin Biol Res 1996;394:211-53.
    Fan S, Meng Q, Gao B, et al. Alcohol stimulates estrogen receptor signaling in human breast cancer cell lines. Cancer Res 2000;60(20):5635-39.
    Steingraber S. Living Downstream. Reading (MA): Addison-Wesley; 1997:248-51.
    Murray RK, Granner DK, Mayes PA, et al. Harper's Biochemistry. 24th ed. Stamford (CT): Appleton & Lange; 1996.
    Guyton AC. Textbook of Medical Physiology. 8th ed. Philadelphia: WB Saunders; 1991.
    Bradlow HL, Telang NT, Sepkovic DW, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrin 1996;150:S259-S65.
    Muti P, Bradlow HL, Micheli A, et al. Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16-hydroxyestrone ratio in premenopausal and postmenopausal women. Epidemiology 2000;11(6):635-40.
    Yager JD, Liehr JG. Molecular mechanisms of estrogen carcinogenesis. Annu Rev Pharmacol Toxicol 1996;36:203-32.
    Westerlind KC, Gibson KJ, Malone P, et al. Differential effects of estrogen metabolites on bone and reproductive tissues of ovarectomized rats. J Bone Miner Res 1998;13(6):1023-31.
    Meilahn EN, De Stavola B, Allen DS, et al. Do urinary oestrogen metabolites predict breast cancer? Guernsey III cohort follow-up. Br J Cancer 1998;78:1250-55.
    Fishman J, Osborne MP, Telang NT. The role of estrogen in mammary carcinogenesis. Ann N Y Acad Sci 1995;768:91-100.
    Zhu BT, Conney AH. Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer Res 1998;58:2269-77.
    Butterworth M, Lau SS, Monks TJ. 17-beta-estradiol metabolism by hamster hepatic microsomes. Implications for the catechol-O-methyl transferase-mediated detoxication of catechol estrogens. Drug Metab Dispos 1996;24(5):588-94.
    Shultz TD, Howie BJ. In vitro binding of steroid hormones by natural and purified fibers. Nutr Cancer 1986;8(2):141-47.
    Adlercreutz H, Hockerstedt K, Bannwart C, et al. Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolites of estrogens and in sex hormone binding globulin (SHBG). J Steroid Biochem 1987;27(4-6):1135-44.
    Cassidy A. Potential tissue selectivity of dietary phytoestrogens and estrogens. Curr Opin Lipidol 1999;10:47-52.
    Brzezinski A, Debi A. Phytoestrogens: the "natural" selective estrogen receptor modulators? Eur J Obstet Gynecol 1999;85:47-51.
    Lissin LW, Cooke JP. Phytoestrogens and cardiovascular health. J Am Coll Cardiol 2000;35(6):1403-10.
    Knight DC, Eden JA. A review of the clinical effects of phytoestrogens. Obstet Gynecol 1996;87(5):897-904.
    Messina MJ, Persky V, Setchell KD, et al. Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr Cancer 1994;21:113-31.
    Kirkman LM, Lampe JW, Campbell DR, et al. Urinary lignan and isoflavonoid excretion in men and women consuming vegetable and soy diets. Nutr Cancer 1995;24(1):1-12.
    Thompson LU, Robb P, Serraino M, et al. Mammalian lignan production from various foods. Nutr Cancer 1991;16(1):43-52.
    London RS, Murphy L, Kitlowski KE, et al. Efficacy of alpha-tocopherol in the treatment of the premenstrual syndrome. J Reprod Med 1987;32:400-04.
    Muneyvirci-Delale O, Nacharaju VL, Altura BM, et al. Sex steroid hormones modulate serum ionized magnesium and calcium levels throughout the menstrual cycle in women. Fertil Steril 1998;69(5):958-62.
    Michnovicz JJ, Adlercreutz H, Bradlow HL. Changes in levels of urinary estrogen metabolites after oral indole-3-carbinol treatment in humans. J Natl Cancer Inst 1997;89(10):718-23.
    Tiwari RK, Guo L, Bradlow HL, et al. Selective responsiveness of human breast cancer cells to indole-3-carbinol, a chemopreventive agent. J Natl Cancer Inst 1994;86(2):126-31.
    Michnovicz JJ, Bradlow HL. Altered estrogen metabolism and excretion in humans following consumption of indole-3-carbinol. Nutr Cancer 1991;16(1):59-66.
    Yuan F, Chen DZ, Liu K, et al. Anti-estrogenic activities of indole-3-carbinol in cervical cells: implication for prevention of cervical cancer. Anticancer Res 1999;19(3A):1673-80.
    Tully DB, Allgood VE, Cidlowski JA. Modulation of steroid receptor-mediated gene expression by vitamin B6. FASEB J 1994;8(3):343-49.
    Minton JP, Walaszek Z, Schooley W, et al. Beta-glucuronidase levels in patients with fibrocystic breast disease. Breast Cancer Res Treat 1986;8:217-22.
    Walaszek Z, Szemraj J, Narog M, et al. Metabolism, uptake, and excretion of a D-glucaric acid salt and its potential use in cancer prevention. Cancer Detect Prev 1997;21(2):178-90.
    Goud VK, Polasa K, Krishnaswamy K. Effect of turmeric on xenobiotic metabolising enzymes. Plant Foods Hum Nutr 1993;44(1):87-92.
    Susan M, Rao MN. Induction of glutathione S-transferase activity by curcumin in mice. Arzneimittelforschung 1992;42(7):962-64.
    Jeong HJ, Shin YG, Kim IH, et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res 1999;22(3):309-12.
    Zhu BT, Loder DP, Cai MX, et al. Dietary administration of an extract from rosemary leaves enhances the liver microsomal metabolism of endogenous estrogens and decreases their uterotropic action in CD-1 mice. Carcinogenesis 1998;19(10):1821-27.
    Maltzman TH, Christou M, Gould MN, et al. Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Carcinogenesis 1991;12:2081.
    Vigushin DM, Poon GK, Boddy A, et al. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Chemother Pharmacol 1998;42:111-17.
    Advanced Nutrition Publications ©2002




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    Quote Originally Posted by JanSz View Post
    rT3 high, how to deal with it


    Use thise three Genova diagnostics tests.

    Comprehensive Thyroid Assesment
    Oxidative Stress Panel (part of NutrEval)
    Elemental Analysis, Packed Erythrocytes (RBC's)(part of NutrEval)


    Read results, follow advice given by those tests.

    So really best would be to use two tests (few extra $$ but lots of informations):
    NutrEval
    Comprehensive Thyroid Assesment
    ---------------------------------------------------------------------------
    -------------------
    -------------------

    High rT3
    5' deiodinase (Se dependent)
    ----------------------------------------------------------
    Selenium also performs other important roles in the body.
    The most important of these is probably as its role as the body's best antioxidant (anti-peroxidant).
    It performs this role as part of glutathione peroxidase (GSHPx or GPX).

    Glutathione Peroxidase (GSH-Px)
    Glutathione peroxidase is a selenium-dependant enzyme found primarily in the cytoplasm (70%) but also in the mitochondria (30%).
    -----------------------------------------------------------------
    Genova Diagnostics' Oxidative Stress Panel
    checks Glutathione Peroxidase
    -----------------------------------------------------------------

    Interactions, (close): (iodine, selenium, zinc, copper)
    ie; at least above four have to be in proper balance
    ---------------------------------------------------------------------------------------------------
    Genova Diagnostics' Elemental Analysis, Packed Erythrocytes (RBC's)
    checks (it is missing iodine):
    TOXICS
    Antimony
    Arsenic
    Cadmium
    Lead
    Mercury
    Thallium
    Tin

    NUTRIENTS
    Chromium
    Copper
    Magnesium
    Manganese
    Potassium
    Selenium
    Vanadium
    Zinc

    ---------------------------------------------------------------------------------------------------
    If the above investigations falls short, further investigations should be made looking into:
    Interactions, (wide range)
    Ag, Co, Cr, Fe, Hg, I,Rb, Sb, Sc, Se, Zn



    -------------------------------------------------------------------------------------------------------------------------------
    http://www.ithyroid.com/iodine.htm
    While I've found research on the interactions of iodine and selenium, there are two other minerals which need to be studied for their interactions with these two: zinc and copper. I found one study which examined the complex interactions of selenium, iodine, and zinc (there are interactions), but none which have looked at all four minerals in a 4 X 4 factorial design. Now that would be an interesting study! Hopefully someone will do that soon.

    I think one lesson from studying the interactions of selenium and iodine is that the interrelationships between minerals are very complicated. Supplementing with one or two can cause further problems. You have to make sure that you correct every deficiency. Health is built from a chain of nutrients and, like a chain, health cannot be accomplished if one nutrient is missing. Sometimes it's complicated putting the chain back together without running into problems (like supplementing with either selenium or iodine, but not both), but every deficiency has to be corrected. John
    Jan, when my RT3 went beyond range, my doc told me it was because I was taking too much Armour. My FT3 was only 330 or so (mid range). I dropped my Armour from 2.5 grains to 1.5 grains. I don't feel differently. I imagine my TSH increased some, and T4 went up as a consequence, thus T3 in turn, balancing the reduction caused by the lesser dose.

    As I recall, you are taking over 3 grains. That's probably too much for you.

    Good luck.
  39. Professional Member
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    ON FERTILITY

    http://www.medsafe.govt.nz/profs/dat...pregnylinj.pdf

    Data Sheet


    Dosage In The Male
    Hypogonadotropic hypogonadism
    1,000-2,000 I.U. PREGNYL, two to three times per week. If the main complaint is subfertility, additional doses of an FSH-containing preparation (75 I.U. FSH) daily or two to three times per week, may be given. This treatment should be continued for at least three months before any improvement in spermatogenesis can be expected. During this treatment testosterone replacement therapy should be suspended. Once achieved, the improvement may in some cases be maintained by hCG alone.
    ============================== ======

    Cancer News Content: Testosterone replacement therapy: Minimizing its impact on fertility

    Clomid and Armidix
    --------------------------------------------------------------------------------------------------------------------
    MESO-Rx - View Single Post - Bloodwork question? Androgel

    Using HCG as a sole/major way of getting proper testosterone levels the natural way.

    Data Sheet
    Follow a protocol that one would use when attempting to be fertile.
    May skip the HMG part, unless want to make sure and get her actualy pregnant.

    The description there says:
    Dosage In The Male
    Hypogonadotropic hypogonadism
    1,000-2,000 I.U. PREGNYL, two to three times per week.

    That translates to
    minimum 2000iu/week
    maximum 6000iu/week

    Your will have few limits, they have to be found by blood testing:

    The more HCG you use,
    the more Testosterone your testis will produce.
    the more estradiol you will have
    the more Arimidex you will have to use to control Estradiol

    You do not want to get more than FreeT~300 and no ness than 160
    Calculated with:
    Free & Bioavailable Testosterone calculator
    Free & Bioavailable Testosterone calculator
    using TotalT, SHBG and Albumin
    or
    chart on post #41
    http://anabolicminds.com/forum/male-...oodtest-2.html


    You do not want to use more than 2 pills/week Arimidex (divided into halfs or quarters)

    So work within this limitations and see if you can be natural.
    .
    .
    Supposedly there is some evidence that frequency 2x/week or E3D is the best.
    Supposedly E2D is not as good.

    You will find out what works for you by trying and testing your reaction..

    ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    MESO-Rx - View Single Post - Dangers of TRT?

    Quote Originally Posted by marianco View Post
    Testosterone replacement therapy increases testosterone levels. This is sensed by the hypothalamus, which then reduces the release of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH) from the Pituitary. Luteinizing Hormone is needed to increase testosterone production from the testes. Follicle Stimulating Hormone is needed to stimulate sperm production.

    When a person has low testosterone and sperm production because of testicular hypofunction, the FSH and LH levels are very high because the brain is trying its hardest to stimulate testosterone production (which also increases sperm production). Testosterone replacement will reduce FSH and LH, causing a reduction in testosterone and sperm production.

    There is more to the story...

    Sperm production is also dependent on having adequate Estrogen Activity and Oxytocin Activity. Both are linked. Estrogen increases Oxytocin release. Estrogen stimulates sperm production and testicular size - just as FSH/LH and its analog HCG do. Oxytocin, itself, can increase sperm production and ejaculate volume. Ejaculate fluid itself is necessary for normal fertility - the sperm alone would be useless in normal sex.

    High estrogen levels can reduce sex drive and can have other adverse effects - such as heart attacks, strokes, and blood clots.

    Low estrogen levels also can reduce sex drive and can have other adverse effects - such as high cholesterol levels, impaired memory - and low sperm production.

    The use of DIM and I3C to reduce estrogen activity may seriously reduce sperm production just as reducing FSH and LH levels (from increasing testosterone levels) can do. If anything, it is important to maintain physiologic estrogen levels to maintain sperm production.

    If a person has low testosterone levels, which can lead to low estrogen levels, it may be important to increase estrogen to normal physiologic levels to stimulate sperm production.

    It is important to balance estrogen with normal progesterone levels - which helps protect the person from some of the risks of estrogen (blood clots, heart attacks, stroke).

    Oxytocin may be considered to raise sperm production and ejaculate volume. However it is a non-usual and a nonstandard treatment even by TRT standards. It can be compounded into a nasal spray - the dose range is about 10-24 IU a day. It is highly important for this to be monitored by a physician. Oxytocin, at its worse, can raise blood pressure, can result in excessive fluid retention, and other potentially fatal risks (just as estrogen can lead to heart attack, stroke and blood clots). These can be monitored on exam and lab testing.
    colkurtz_spf testicle restoration timeline:
    TRT WORKS, My results have been amazing!!

    jinxie
    hCG Monotherapy Success Story -- Staggering Numbers

    schedule on post #16
    hCG Monotherapy Success Story -- Staggering Numbers


    ==========
    ==========
    ==========
    MERC MANUAL
    http://74.125.47.132/search?q=cache:...ient=firefox-a
    Treatment of infertility due to hypogonadism

    Infertility, which has many possible causes other than hypogonadism, is discussed in full elsewhere (see Infertility). Infertility due to primary hypogonadism does not respond to hormonal therapy. Men with primary hypogonadism occasionally have a few intratesticular sperm that can be harvested with various microsurgical techniques and used to fertilize an egg by an assisted reproductive technique (eg, intracytoplasmic injection).

    Infertility due to secondary hypogonadism usually responds to gonadotropin replacement therapy. Other symptoms of secondary hypogonadism respond well to testosterone replacement therapy alone. If secondary hypogonadism results from pituitary disease, gonadotropin replacement therapy usually is successful. Therapy begins with LH replacement. After all exogenous androgens are stopped, LH replacement is generally initiated using human chorionic gonadotropin (hCG). Doses begin at 375 to 750 IU sc 2 to 3 times/wk and are increased if necessary to 1000 to 2000 IU sc 2 to 3 times/wk. The dose is adjusted after 3 mo to achieve normal serum testosterone levels. Sperm counts are done monthly, but counts are not expected to increase for at least 4 mo. FSH replacement, which is expensive, begins if 6 to 12 mo of LH replacement does not stimulate spermatogenesis. FSH replacement uses human menotropic gonadotropin or human recombinant FSH, beginning with 75 to 150 IU 3 times/wk. The dose may be doubled if conception has not occurred within 6 mo of combination therapy with hCG. Many men become fertile with treatment despite sperm counts that do not usually result in fertility (eg, < 5 million/mL).

    Secondary hypogonadism due to a hypothalamic defect (eg, Kallmann's syndrome) is treated initially with LH and FSH because of their ready availability; if these are ineffective, GnRH replacement therapy (q 2 h sc by a programmable minipump) might be more effective. Most (80 to 90%) of men respond successfully to these regimens.

    Last full review/revision June 2007 by Bradley D. Anawalt, MD
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    Cancer


    Risks of Nutrition Therapy
    In an extensive review of the literature, Dr. Adrienne Bendich found the following data on nutrient toxicity59:

    B-6 can be used at up to 500 mg (250 times RDA) for up to 6 years with safety.

    Niacin (as nicotinic acid) has been recommended by the National Institute of Health for lowering cholesterol at doses of 3000-6000 mg/day (150-300 times RDA). Time release niacin is more suspect of causing toxicity as liver damage.

    Vitamin C was tested in eight published studies using double blind placebo controlled design. At 10,000 mg/day for years, vitamin C produced no side effects.

    High doses of vitamin A (500,000 iu daily) can have acute reversible effects. Teratogenecity is the most likely complication of high dose vitamin A intake.

    Vitamin E intake at up to 3000 mg/day for prolonged periods has been shown safe.

    Beta-carotene has been administered for extended periods in humans at doses up to 180 mg (300,000 iu) with no side effects or elevated serum vitamin A levels.


    In a separate review of the literature on nutrient toxicity by John Hathcock, PhD, a Food and Drug Administration toxicologist, the following data was reported60:

    Vitamin A toxicity may start as low as 25,000 iu/day (5 times RDA) in people with impaired liver function via drugs, hepatitis, or protein malnutrition. Otherwise, toxicity for A begins at several hundred thousand iu/day.

    Beta-carotene given at 180 mg/day (300,000 iu or 60 times RDA) for extended periods produced no toxicity, but mild carotenemia (orange pigmentation of skin).

    Vitamin E at 300 iu/day (10 times RDA) can trigger nausea, fatigue, and headaches in sensitive individuals. Otherwise, few side effects are seen at up to 3,200 iu/day.

    B-6 may induce a reversible sensory neuropathy at doses of as low as 300 mg/day in some sensitive individuals. Toxic threshold usually begins at 2000 mg for most individuals.

    Vitamin C may induce mild and transient gastro-intestinal distress in some sensitive individuals at doses of 1000 mg (16 times RDA). Otherwise, toxicity is very rare at even high doses of vitamin C intake.

    Zinc supplements at 300 mg (20 times RDA) have been found to impair immune functions and serum lipid profile.
    Iron intake at 100 mg/day (6 times RDA) will cause iron storage disease in 80% of population. The "window of efficacy" on iron is probably more narrow than with other nutrients.

    Copper can be toxic, though dose is probably related to the ratio with other trace minerals.

    Selenium can be toxic at 1-5 mg/kg body weight intake. This would equate to 65 mg/day for the average adult, which is 812 times the RDA of 80 mcg. Some sensitive individuals may develop toxicity at 1000 mcg/day.

    Manganese can be toxic, though little specific information can be provided for humans.

    .
  

  
 

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