EvoMuse Gut Health

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    Quote Originally Posted by MidwestBeast View Post

    lol might as well.

    Some of my supps I buy for 6 months to a year's worth supply at once. Did it with Orange Triad back during one of NP's ridiculous sales a while back and still have a couple bottles left and just stocked up on about 5 more bottles of Compete.

    I will likely do the same with Gut Health.
    You do love your Compete. and now stash up the Gut Health
    EvoMuse

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    I'm reaching the end of my one Gut Health bottle (I have two more left). What is the ETA of the new stuff?
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    Still nothing...
    •   
       

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    Matt had said AROUND the 12th so should be soon. Need to stock up
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    Quote Originally Posted by dollar662 View Post
    Matt had said AROUND the 12th so should be soon. Need to stock up
    The word is sometime this upcoming week.
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    We JUST got ingredients cleared and delivered guys. We have a fast track on production that Matt paid for out of pocket to deliver this even faster. It is looking like the end of next week possibly as early as Thursday sales. Get excited!
    EvoMuse Products Rep

    PM me with any questions!
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    Quote Originally Posted by Geoforce View Post
    We JUST got ingredients cleared and delivered guys. We have a fast track on production that Matt paid for out of pocket to deliver this even faster. It is looking like the end of next week possibly as early as Thursday sales. Get excited!
    You don't have to tell me twice
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    :want:

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    Slick new bottles very well designed
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    Sexy
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    cannot wait
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    Did someone say Gut Health?

    http://journals.cambridge.org/abstra...0711451200373X

    Cholesterol-lowering efficacy of Lactobacillus plantarum CECT 7527,
    7528 and 7529 in hypercholesterolaemic adults
    Mari C. Fuentes1, Teresa Lajo2, Juan M. Carrio´n3 and Jordi Cun˜e´1*
    1AB-BIOTICS S.A., Cerdanyola del Valle`s, Edifici Eureka, Campus UAB, 08193 Bellaterra, Spain
    2Department of Endocrinology and Nutrition, Moncloa Hospital, Madrid, Spain
    3Department of Endocrinology and Nutrition, Torrelodones University Hospital, Torrelodones-Madrid, Spain
    (Submitted 30 March 2012 – Final revision received 19 July 2012 – Accepted 21 July 2012)
    Abstract
    Previous studies have indicated that supplementation with probiotic bacteria may improve lipid metabolism. The present study was aimed
    at investigating the effects of a mixture of three strains of Lactobacillus plantarum (CECT 7527, CECT 7528 and CECT 7529) on cholesterollowering
    efficacy in hypercholesterolaemic patients. A total of sixty volunteers (thirty participants in the placebo group and thirty counterparts
    in the L. plantarum group), aged 18–65 years old, participated in a controlled, randomised, double-blind trial. The study group
    received one capsule daily containing 1·2 £ 109 colony-forming units of Lactobacillus strains in a unique dose; the placebo group consumed
    the same product without bacteria for 12 weeks. A significant reduction of 13·6% in plasma total cholesterol (TC) levels was
    observed after 12 weeks of consumption in the L. plantarum group when compared with the placebo group. The lipidic
    outcomes were also analysed based on TC values at baseline: low initial values (LIV, 2000–2500 mg/l) v. high initial values (HIV,
    2510–3000 mg/l). In the HIV group, the L. plantarum treatment showed a reduction after 12 weeks of consumption compared with the
    placebo group in TC, LDL-cholesterol (LDL-C) and oxidised LDL-C (17·4, 17·6 and 15·6 %, respectively). In the LIV, the L. plantarum treatment
    only showed a reduction after 12 weeks of consumption when compared with the placebo group in TC (9·4 %). The present results
    showed that the biofunctionality of L. plantarum (CECT 7527, CECT 7528 and CECT 7529) is proportional to the cardiovascular risk of the
    patient, having a better effect in patients with higher levels of cholesterol.
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    I think I may try this for the first time, any suggestions?
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    Suggestions?
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    I saw that it is posted on Nutraplanet waiting for an intro sale. I am going to be placing an order, just waiting on this, any ETA?
    For my unsponsored log/review of Brite follow along: http://anabolicminds.com/forum/supplement-reviews-logs/253421-comes-down-simple.html#post4577125
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    Quote Originally Posted by WeaponX1984 View Post
    I saw that it is posted on Nutraplanet waiting for an intro sale. I am going to be placing an order, just waiting on this, any ETA?
    Should be there Tuesday!
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    First time user, follow the label? What should I notice? Take for how long?
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    Quote Originally Posted by testosteronet View Post
    First time user, follow the label? What should I notice? Take for how long?
    I always take one cap with my last meal of the day. I follow the label directions, though. Some take 2 caps for the first 5 days, and then drop to one.
    EvoMuse
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    Quote Originally Posted by domore View Post
    I always take one cap with my last meal of the day. I follow the label directions, though. Some take 2 caps for the first 5 days, and then drop to one.
    Any method can work though, right?

    I like to take mine first thing in the morning about two hours before my first meal. It's when my stomach is at its emptiest state so the pill can travel furthest down the tract.
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    Quote Originally Posted by ArtsNSports View Post
    Any method can work though, right?

    I like to take mine first thing in the morning about two hours before my first meal. It's when my stomach is at its emptiest state so the pill can travel furthest down the tract.
    Yeah, any time is fine.
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    Quote Originally Posted by ArtsNSports View Post

    Any method can work though, right?

    I like to take mine first thing in the morning about two hours before my first meal. It's when my stomach is at its emptiest state so the pill can travel furthest down the tract.
    Quote Originally Posted by dsade View Post
    Yeah, any time is fine.
    Yup. You can take it anytime as Matt just said. I just find it convenient to take with dinner.
    EvoMuse
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    Gut Health™

    In an age where we view our body as our temple, we’re constantly looking for ways to improve the function and capacity of our inner machine. All of the nutrients that we take in on a daily basis through food consumption are utilized by our body in different ways. However, far too often many of the intended benefits of those nutrients are never fully translated into improved health and vitality. Here’s why…
    Our body’s digestive tract is literally a microbial battlefield, and unless you have the right troops to lead into battle on a daily basis, you’re going to continue to fight an uphill war. This is severely limiting your inner machines natural robust potential of nutrient absorption, nutrient delivery, and resilient immune function. Imagine a dietary probiotic supplement that can help provide those vital and essential troops on a daily basis leading to improved terminal and systemic functions of the natural digestive process.
    EvoMuse is proud to present a newly updated formula of the original 2006 released product, Gut Health™. The original probiotic product designed for the fitness enthusiast just got better!
    Representing the latest in probiotic technology, Gut Health™ contains a specialized force of complementary probiotic strains that have been assembled to maximize and improve your overall health, fitness goals, and overall well- being.
    Some of these notable improvements include:
    • Optimizing nutrient absorption and utilization
    • Improved overall immune function
    • Limiting GI distress related to a high protein diet
    • Reduced bowel irritation/inflammation
    • Supporting a healthy and beneficial symbiotic GI environment




    The new and improved Gut Health™ contains 1 billion CFU each of the following synergistic and beneficial probiotic strains along with their evinced associated benefits:
    • Bacillus Coagulens: has been shown to decrease abdominal pain and bloating that’s associated with a high protein diet in the normal digestive process.
    • Bacillus Subtilis: has been shown to stimulate and improve innate immune function improving overall systemic function.
    • Lactobacillus Casei: has been shown to reduce lactose intolerance, enhance nutrient digestion and absorption, and reduce GI inflammatory factors.
    • Streptococcus Thermophilae: has been shown to reduce GI inflammatory factors and have potent immunomodulatory and anticarcinogenic effects.
    • Lactobacillus Plantarum: has been shown to promote protein absorption/ utilization and reduce GI inflammatory factors .
    • Bifidobacterium Breve: has been shown to alleviate gas symptoms typical with high protein ingestion, reduce bloating, and have powerful immunomodulary effects. This is evinced by potent competitive exclusion properties of harmful bacteria such as E coli that can typically cause GI related distress and disease.

    To ensure superior delivery of our product, we’ve utilized our innovative entericap technology in Gut Health™ that will shuttle these super strains of good bacteria past the acidic environment of the stomach and introduce them directly into the intestinal system; where these strains will flourish, multiply, and ultimately boost our performance by leveling the microbial battlefield.
    It’s time to go to war with our “Gut” and fight back against inadequate nutrient uptake and compromised immune function. EvoMuse has carefully assembled a complete probiotic formulation that has been specifically designed to dramatically improve your fitness related goals, overall health, and vitality.

    Let Gut Health™ lead the way!
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    http://www.ncbi.nlm.nih.gov/m/pubmed/20980636


    Lactobacillus plantarum consumption increases PepT1-mediated amino acid absorption by enhancing protein kinase C activity in spontaneously colitic mice.
    J. Nutr. 2010 (12):2201-6
    Hong-Qi Chen, Tong-Yi Shen, Yu-Kun Zhou, Ming Zhang, Zhao-Xin Chu, Xiao-Min Hang, Huan-Long Qin


    Although probiotic consumption has generally been shown to have many beneficial effects for the prevention and treatment of inflammatory bowel disease, the effects of Lactobacillus plantarum (LP) on intestinal nutrient absorption, particularly oligopeptide transporter 1 (PepT1)-mediated absorption of dietary protein under inflammatory conditions, has not yet been characterized. In this study, we first investigated the effects of LP consumption on plasma amino acid concentrations and PepT1-mediated absorption of cephalexin in the small intestine of wild-type (WT) mice and interleukin-10 knockout (IL-10(-/-)) mice, a model of spontaneous colitis. We then analyzed expression and distribution of PepT1 and protein kinase C (PKC) activity in the jejunum of these mice. LP consumption (10(9) colony-forming units/0.5 mL) delivered by gavage once per day for 4 wk increased the total plasma amino acid concentration and the concentration of plasma cephalexin through enhancement of PepT1-mediated uptake in LP treated IL-10(-/-) mice compared with IL-10(-/-) mice. However, Western blotting and quantitative PCR analysis revealed no significant differences in PepT1 protein and mRNA expression between LP-treated and untreated mice. Additionally, immunofluorescence analysis showed that PepT1 did not appear to be mislocalized in IL-10(-/-) mice. Interestingly, IL-10(-/-) mice had significantly lower PKC activity and expression of phosphorylated PKC compared with WT mice, and these decreases could be prevented by LP treatment. These data suggest that consumption of LP enhances PepT1-mediated amino acid absorption, likely through alterations in PKC activity, as opposed to changes in expression or distribution of PepT1 in the small intestine of IL-10(-/-) mice.




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    INteresting study here:
    J Sci Food Agric. 2013 Mar 30;93(5):1219-25. doi: 10.1002/jsfa.5880. Epub 2012 Sep 21.
    The effect of probiotic-fermented soy milk on enhancing the NO-mediated vascular relaxation factors.

    Cheng CP, Tsai SW, Chiu CP, Pan TM, Tsai TY.
    Source

    Department of Food Science, Fu Jen Catholic University, Taipei, Taiwan.

    Abstract

    BACKGROUND:

    Soy milk is one of the common soy-based foods in Asia. In this study the effects of soy milk fermented with selected probiotics on nitric oxide (NO)-mediated vascular relaxation factors in cell model systems were investigated.
    RESULTS:

    Soy milk fermented with Lactobacillus plantarum TWK10 or Streptococcus thermophilus BCRC 14085 for 48 h showed a greater transformation of glucoside isoflavones to aglycone isoflavones (P < 0.05). An increase in aglycone isoflavones in ethanol extracts from fermented soy milk stimulated NO production and endothelial NO synthase (eNOS) activity in human umbilical vein endothelial cells. It also had a stimulating effect on superoxide anion scavenging and prostaglandin E2 production. In addition, it enhanced mRNA expression of the E-prostanoid 4 receptor in rat thoracic aorta smooth muscle cells. Moreover, a small amount of O$_{2}^{-}$ induced by water extracts from fermented soy milk at low concentration (1 mg mL(-1) ) increased the content of calcium ions and activated eNOS, thereby promoting NO production and the coupling state of eNOS.
    CONCLUSION:

    Soy milk fermented with selected probiotics promotes the relaxation factors of vascular endothelial cells and can be applied in the development of functional foods. © 2012 Society of Chemical Industry.
    © 2012 Society of Chemical Industry
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    Gut Microbes. 2012 Nov-Dec;3(6):523-9. doi: 10.4161/gmic.21757. Epub 2012 Aug 16.
    Lactic acid production by Streptococcus thermophilus alters Clostridium difficile infection and in vitro Toxin A production.

    Kolling GL, Wu M, Warren CA, Durmaz E, Klaenhammer TR, Guerrant RL.
    Source

    Department of Internal Medicine/Division of Infectious Diseases, University of Virginia, Charlottesville, VA, USA. glk3a@virginia.edu

    Abstract

    Antibiotic treatment to treat specific infections has the potential to effectively target the offending microbe as well as other microbes that colonize sites within a host. Antibiotic-associated diarrhea (AAD) is a classic example resulting from disruption of host microbial communities; 20% of patients with AAD are likely to become colonized with Clostridium difficile. Restoration of a "normal" microbial community within the host using probiotic bacteria is one approach to circumvent AAD and C. difficile infection. The goals of this study were to assess the interactions between Streptococcus thermophilus, a potential probiotic organism and C. difficile using both in vitro and in vivo systems. Exposure of C. difficile to filtered supernatants from S. thermophilus showed a dose-dependent, bactericidal effect due to lactic acid. Additional studies show that levels of lactic acid (10 mM) that did not inhibit bacterial growth had the potential to decrease tcdA expression and TcdA release into the extracellular milieu. In vivo, treatment with viable S. thermophilus significantly increased luminal levels of lactate in the cecum compared with UV-irradiated S. thermophilus. In the context of infection with C. difficile, mice treated with viable S. thermophilus exhibited 46% less weight loss compared with untreated controls; moreover, less pathology, diarrhea, and lower detectable toxin levels in cecal contents were evident more often in S. thermophillus treated mice. A significant, inverse correlation (Spearman r = -0.942, p = 0.017) between the levels of luminal lactate and abundance of C. difficile were noted suggesting that lactate produced by S. thermophilus is a factor impacting the progression of C. difficile infection in the murine system.


    PMID:22895082 [PubMed - in process]
    PMCID:PMC3495789 [Available on 2013/11/1]
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    J Agric Food Chem. 2012 Jan 18;60(2):554-65. doi: 10.1021/jf202176d. Epub 2012 Jan 5.
    Variability of hydrolysis of β-, αs1-, and αs2-caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides.

    Miclo L, Roux E, Genay M, Brusseaux E, Poirson C, Jameh N, Perrin C, Dary A.
    Source

    Unité de Recherche Animal et Fonctionnalités des Produits Animaux (UR AFPA), Équipe Protéolyse et Biofonctionnalités des Protéines et des Peptides (PB2P), Nancy-Université, Vandœuvre-lès-Nancy, France.

    Abstract

    Milk proteins contain numerous potential bioactive peptides, which may be released by digestive proteases or by the proteolytic system of lactic acid bacteria during food processing. The capacity of Streptococcus thermophilus to generate peptides, especially bioactive peptides, from bovine caseins was investigated. Strains expressing various levels of the cell envelope proteinase, PrtS, were incubated with α(s1)-, α(s2)-, or β-casein. Analysis of the supernatants by LC-ESI-MS/MS showed that the β-casein was preferentially hydrolyzed, followed by α(s2)-casein and then α(s1)-casein. Numbers and types of peptides released were strain-dependent. Hydrolysis appeared to be linked with the accessibility of different casein regions by protease. Analysis of bonds hydrolyzed in the region 1-23 of α(s1)-casein suggests that PrtS is at least in part responsible for the peptide production. Finally, among the generated peptides, 13 peptides from β-casein, 5 from α(s2)-casein, and 2 from α(s1)-casein have been reported as bioactive, 15 of them being angiotensin-converting enzyme inhibitors.


    PMID:22103626 [PubMed - indexed for MEDLINE]
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    Clin Exp Immunol. 2011 Jul;165(1):94-103. doi: 10.1111/j.1365-2249.2011.04408.x. Epub 2011 May 5.
    Lactobacillus rhamnosus GG and Streptococcus thermophilus induce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages.

    Latvala S, Miettinen M, Kekkonen RA, Korpela R, Julkunen I.
    Source

    Department of Vaccination and Immune Protection, National Institute for Health and Welfare (THL), University of Helsinki, Finland. sinikka.latvala@thl.fiilkka.ju lkunen@thl.fi

    Abstract

    In the present study we have characterized T helper type 2 (Th2) [interleukin (IL)-10]/Th1 (IL-12) cytokine expression balance in human primary macrophages stimulated with multiple non-pathogenic Gram-positive bacteria used in the food industry and as probiotic substances. Bacteria representing Lactobacillus, Bifidobacterium, Lactococcus, Leuconostoc, Propionibacterium and Streptococcus species induced anti-inflammatory IL-10 production, although quantitative differences between the bacteria were observed. S. thermophilus was able to induce IL-12 production, while the production of IL-12 induced by other bacteria remained at a low level. The highest anti-inflammatory potential was seen with bifidobacteria, as evidenced by high IL-10/IL-12 induction ratios. All studied non-pathogenic bacteria were able to stimulate the expression of suppressor of cytokine signalling (SOCS) 3 that controls the expression of proinflammatory cytokine genes. Lactobacillus and Streptococcus species induced SOCS3 mRNA expression directly in the absence of protein synthesis and indirectly via bacteria-induced IL-10 production, as demonstrated by experiments with cycloheximide (CHX) and anti-IL-10 antibodies, respectively. The mitogen-activated protein kinase (MAPK) p38 signalling pathway played a key role in bacteria-induced SOCS3 gene expression. Enhanced IL-10 production and SOCS3 gene expression induced by live non-pathogenic Lactobacillus and Streptococcus is also likely to contribute to their immunoregulatory effects in vivo.
    © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.


    PMID:21545585 [PubMed - indexed for MEDLINE]
    PMCID:PMC3110325
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    And the ballgame starts early...get them quick for they will not last long.

    Remember the old price of the 75 count at $30? Well, I promised you a better and cheaper product...

    1 bottle for $22.50, 2 or more bottles only $19.50

    http://www.nutraplanet.com/product/e...w-formula.html
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    Awesome. Picking some up today.
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    Quote Originally Posted by breezy11 View Post
    Awesome. Picking some up today.
    Same here.
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    WOW its a steal at 2+ bottles picking up 3 later today for sure
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    Quote Originally Posted by breezy11 View Post
    Awesome. Picking some up today.
    Quote Originally Posted by testosteronet View Post
    Same here.
    Quote Originally Posted by dollar662 View Post
    WOW its a steal at 2+ bottles picking up 3 later today for sure
    Appreciate your enthusiam Gents! : )
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    I'm working on a much more specific scientific breakdown of each individual probiotic strain that's contained in our new "Gut Health" product for those of you that like that kind of stuff.

    This is a very complete and synergistic formulation. This is the type of product that will benefit everyone; ranging from aspects of baseline health, to improving aspects of your training/recovery.

    There's a great deal over at Nutraplanet as we speak!


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    Quote Originally Posted by Trauma1 View Post
    I'm working on a much more specific scientific breakdown of each individual probiotic strain that's contained in our new "Gut Health" product for those of you that like that kind of stuff.

    This is a very complete and synergistic formulation. This is the type of product that will benefit everyone; ranging from aspects of baseline health, to improving aspects of your training/recovery.

    There's a great deal over at Nutraplanet as we speak!


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    Nice! I can't wait to read it. That's why we like you; you smarty pants
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    Definitely scooping some of this up.
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    The intro sale on this is insane. I had no idea these would be that cheap. 10 dollars for a month supply (keep in mind every bottles is two months worth). Matt said he wanted this to be affordable for everyone. It's going to be really hard to beat this intro sale guys.
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    Quote Originally Posted by Geoforce View Post
    The intro sale on this is insane. I had no idea these would be that cheap. 10 dollars for a month supply (keep in mind every bottles is two months worth). Matt said he wanted this to be affordable for everyone. It's going to be really hard to beat this intro sale guys.
    Couldn't agree more. I'm going to stock up.

    Very excited about this price point for the introduction of the new and improved version
    Psalm 34:10 - "The lions may grow weak and hungry, but those who seek the Lord lack no good thing."
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    When you finish a bottle and start a new one, do you prefer to do the double-dose again for 5 days or do you just keep taking 1 capsule per day?
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    Quote Originally Posted by ArtsNSports View Post
    When you finish a bottle and start a new one, do you prefer to do the double-dose again for 5 days or do you just keep taking 1 capsule per day?
    With a few exceptions (antibiotics, drinking binge) keep taking 1 cap a day indefinitely.
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