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    Quote Originally Posted by prld2gr8ns

    There seems to be a growing trend of Including Y in a lot of new formulated fat burners. I'm one of the folks that will not touch it with a 10 ft pole. To each there own though, it good at what it does.
    I eat too often for Y to have a large enough effect. Unfortunate...

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    Quote Originally Posted by uvawahoowa View Post
    I eat too often for Y to have a large enough effect. Unfortunate...
    Doing intermittent fasting Y-HCL is awesome for fasted AM cardio, melts the belly fat.
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    No yohimbine. Better then that.
    ...Fat Burning, GDA, Muscle Building, Sleep Enhancing, Strength Enhancing Supplements...
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    I'm still trying to figure out the whole vanilla angle. Lol
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    Quote Originally Posted by BulkPerf View Post
    No yohimbine. Better then that.
    interesting......
    doing my own thang!
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    Quote Originally Posted by BulkPerf View Post
    No yohimbine. Better then that.
    Rauwolscine'd be my guess then
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    Quote Originally Posted by Resolve View Post
    Rauwolscine'd be my guess then
    crossing my fingers
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    Quote Originally Posted by Resolve View Post
    Rauwolscine'd be my guess then
    Eh...so yesterday!
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons
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    Quote Originally Posted by Resolve View Post
    Rauwolscine'd be my guess then
    Quote Originally Posted by jwa254 View Post
    crossing my fingers
    Nope.


    Quote Originally Posted by AZMIDLYF View Post
    Eh...so yesterday!
    Very true.
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    Evodiamine?
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    Quote Originally Posted by jwa254 View Post
    Evodiamine?
    Using FB to cheat lol.
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    Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
    Wang T, Wang Y, Yama****a H.
    Source

    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan.
    Abstract

    The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCalpha, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway was revealed.

    PMID:



    19854188



    [PubMed - indexed for MEDLINE]
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    Activation of TRPV1 and TRPA1 by black pepper components.
    Okumura Y, Narukawa M, Iwasaki Y, Ishikawa A, Matsuda H, Yoshikawa M, Watanabe T.
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    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizouka, Japan.
    Abstract

    We searched in this study for novel agonists of transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and transient receptor potential cation channel, subfamily A, member 1 (TRPA1) in pepper, focusing attention on 19 compounds contained in black pepper. Almost all the compounds in HEK cells heterogeneously expressed TRPV1 or TRPA1, increased the intracellular Ca(2+) concentration ([Ca(2+)](i)) in a concentration-dependent manner. Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1. The EC(50) values of these compounds for TRPV1 were 0.6-128 microM. Piperine, isopiperine, isochavicine, piperanine, piperolein A, piperolein B, and N-isobutyl-(2E,4E)-tetradeca-2,4-diamide also relatively strongly activated TRPA1, the EC(50) values of these compounds for TRPA1 were 7.8-148 microM. The Ca(2+) responses of these compounds for TRPV1 and TRPA1 were significantly suppressed by co-applying each antagonist. We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.

    PMID:



    20460725



    [PubMed - indexed for MEDLINE]
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    Any Raspberry Ketones involved as well?
    Always open light. Itís not what you open with, itís what you finish with. Louie Simmons
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    Quote Originally Posted by BulkPerf View Post
    Using FB to cheat lol.
    Hey! I'm just on the up and up! I'm now scouring PubMed and the rest of the interwebs for information.
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    Few more weeks.
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    Quote Originally Posted by BulkPerf View Post
    Evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway.
    Wang T, Wang Y, Yama****a H.
    Source

    Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Kasugai 487-8501, Japan.
    Abstract

    The molecular mechanism of the anti-adipogenic effect of evodiamine (which has several capsaicin-like pharmacological actions) was investigated. The evodiamine effect was not blocked by the specific TRPV1 antagonist capsazepine in 3T3-L1 preadipocytes, whereas its effect was greatly curtailed by inhibitors of protein kinase C (PKC) and epidermal growth factor receptor (EGFR). Signal analyses showed that evodiamine stimulated the phosphorylation of EGFR, PKCalpha, and ERK, all of which were reduced by an EGFR inhibitor. Silencing experiments of EGFR mRNA supported the involvement of these signaling molecules in the inhibitory effect of evodiamine. An unidentified mechanism whereby evodiamine inhibits adipogenesis via the EGFR-PKCalpha-ERK signaling pathway was revealed.

    PMID:



    19854188



    [PubMed - indexed for MEDLINE]
    I remember trying Redline RTDs 5 or 6 years ago and that stuff was unbelievable. Best stim-rush ever, but I remember seeing evodiamine on the ingredient panel and wondered at the time if that was the medical name for liquid crack.
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    Well I can only say that from what I am reading Vanillean doesn't have any of the "usual suspects". Sounds anything but "Vanilla" to me!
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    Quote Originally Posted by MrKleen73 View Post
    Well I can only say that from what I am reading Vanillean doesn't have any of the "usual suspects". Sounds anything but "Vanilla" to me!
    Granted we know as much as you guys do, Vanillean should be very different and very new. I have never questioned BPS because everything does what it says, I can only imagine Vanillean will be yet another great product.
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    Yes I agree that BPS is a straight shooter company.
    doing my own thang!
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    I cannot wait for this to release! The anticipation is killing me.
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    Quote Originally Posted by andrew732 View Post
    Yes I agree that BPS is a straight shooter company.
    Now that right there is an endorsement you can believe in. You shoot straight yourself and are extremely knowledgeable so your opinion is taken in high regard!
    Quote Originally Posted by jwa254 View Post
    I cannot wait for this to release! The anticipation is killing me.
    I am ready for it too! As Ouffiny mentioned we are just as excited as anyone else to find out exactly what it is and they science behind it.
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    Little more info since the release is very near.

    A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation.Earley S, Gonzales AL, Garcia ZI.
    Source


    Department of Biomedical Sciences, Colorado State University, Fort Collins, CO 80523-1680, USA. scott.earley@colostate.edu
    Abstract


    The Mediterranean diet may be responsible for lower cardiovascular disease rates in Southern versus Northern European countries. Oregano is used abundantly in Mediterranean cooking, but potential cardiovascular benefits have not been investigated. Carvacrol, present in oregano, activates the transient receptor potential (TRP) cation channels TRPA1 and TRPV3. We hypothesized that chemosensing of this dietary molecule by TRP channels in the endothelium promotes arterial relaxation. TRPA1 and TRPV3 were detected in the endothelium of intact arteries. Carvacrol causes concentration-dependent increases in the intracellular [Ca(2+)] of native cerebral artery endothelial cells and is more potent (EC(50) = 34 microM) than the TRPA1 agonist allyl isothiocyanate (EC(50) = 400 microM) or the TRPV3 agonist eugenol (EC(50) = 2.3 mM). Carvacrol also activates TRPV3-like cation currents in cerebral artery endothelial cells. Carvacrol elicits vasodilation of intact cerebral arteries (EC(50) = 4.1 microM) that is accompanied by smooth muscle hyperpolarization and a decrease in the intracellular [Ca(2+)] of arterial myocytes. Endothelium disruption inhibits carvacrol-induced vasodilation, but block of nitric-oxide synthase and cyclooxygenase activity does not alter the response. Vasodilation in response to carvacrol is inhibited when blockers of Ca(2+)-activated K(+) channels are present in the lumen or when the inwardly rectifying K(+) channel blocker BaCl(2) is present in the superfusion bath. Carvacrol-induced dilation is not diminished by a TRPA1 antagonist but is inhibited by the TRPV blocker ruthenium red. Our findings show that oregano can relax arteries by activating TRPV3 channels in the endothelium. This effect may account for some of the cardioprotective effects of the Mediterranean diet.


    PMID:
    20086034
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2845943
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    So evodiamine and an oregano extract? Did I read that right?
    If my direct and cynical approach bothers you, just ignore it. I'm just saying what you need to hear ;).
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    I assume Vanillalean will replace combustion
    doing my own thang!
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    That and we have something in the works to really Zapp appetite away.
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    Does this appetite suppressant act synergestically with VanillaLean?
    doing my own thang!
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    Lets get this bad boy released and celebrate by sending me a free bottle
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    PM me with any questions!
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    Quote Originally Posted by BulkPerf View Post
    Little more info since the release is very near.
    Oh stop the teasing already!!!
    OG Avenger-HULK SMASHING TIME!

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    GDI... I want MOAR info on ALL the products on the horizon! Guy, BPS is teasing us just as much as ya'll...
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