Sex, Masturbation and Testosterone Levels Reloaded Pt. 2
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Ejaculation Frequency vs. Testosterone Level:
1.
http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract - "The purpose of this study is to gain understanding of the relationship between ejaculation and serum testosterone level in men. The serum testosterone concentrations of 28 volunteers were investigated daily during abstinence periods after ejaculation for two phases. The authors found that the fluctuations of testosterone levels from the 2nd to 5th day of abstinence were minimal. On the 7th day of abstinence, however, a clear peak of serum testosterone appeared, reaching 145.7% of the baseline ( P < 0.01). No regular fluctuation was observed following continuous abstinence after the peak. Ejaculation is the precondition and beginning of the special periodic serum testosterone level variations, which would not occur without ejaculation. The results showed that ejaculation-caused variations were characterized by a peak on the 7th day of abstinence; and that the effective time of an ejaculation is 7 days minimum. These data are the first to document the phenomenon of the periodic change in serum testosterone level; the correlation between ejaculation and periodic change in the serum testosterone level, and the pattern and characteristics of the periodic change." also in
http://www.ncbi.nlm.nih.gov/pubmed/1...ystem2.PEntrez
.Pubmed.Pubmed_ResultsPanel.Pu bmed_RVDocSum
2.
http://www.ncbi.nlm.nih.gov/pubmed/1...?dopt=Abstract - "This current study examined the effect of a 3-week period of sexual abstinence on the neuroendocrine response to masturbation-induced orgasm. Hormonal and cardiovascular parameters were examined in ten healthy adult men during sexual arousal and masturbation-induced orgasm. Blood was drawn continuously and cardiovascular parameters were constantly monitored. This procedure was conducted for each participant twice, both before and after a 3-week period of sexual abstinence. Plasma was subsequently analysed for concentrations of adrenaline, noradrenaline, cortisol, prolactin, luteinizing hormone and testosterone concentrations. Orgasm increased blood pressure, heart rate, plasma catecholamines and prolactin. These effects were observed both before and after sexual abstinence. In contrast, although plasma testosterone was unaltered by orgasm, higher testosterone concentrations were observed following the period of abstinence. These data demonstrate that acute abstinence does not change the neuroendocrine response to orgasm but does produce elevated levels of testosterone in males."
3. American population testosterone level dropped about 50 ng/dl for men at around age 64-65 between 2 groups of men born in 1920-1924 and 1930-1934, according to in
http://jcem.endojournals.org/cgi/reprint/92/1/196. When the 1920-1924 group reached the median age 65, their mean testosterone level was 500 ng/dl; when the 1930-1934 group reached the median age 56 and 64, their mean testosterone was 529 ng/dl and 444 ng/dl, respectively. The 1930-1934 group has a testosterone drop rate at about 10.65 ng/dl per year during ages 56-64. This report also shows that the testosterone drop rate generally becomes faster for the men from 55 to 65. If we use the same annual drop rate of the 1930-1934 group, the extrapolated, averaged testosterone level of of 20 year old men born during 1930-1934 should be about 911 ng/dl. Assuming that the mean 20-year old testosterone level for both groups are the same is about 911 ng/dl, the overall-averaged testosterone drop for the 1920-1924 group is about 9.13 ng/dl/year, while the overall-averaged testosterone drop for the 1930-1934 group is about 10.61 ng/dl/year I suspect the higher masturbation/ejaculation frequency in the younger generation after the 60's sexual revolution resulted in a higher cortisol/ prolactin level (or faster ageing of the hypothalamus-pituitary-adrenal and -testicular axis) accelerates the testosterone drop, since some high-frequency over-masturbation young men experience male menopause (andropause) between ages 20-30.
4. Our observations for healthy ejaculation frequency (or refraction times) vs age, in order to maximize the testosterone level, are:
1. 4-7 times per week for teenagers of age 16-19.
2. 3-6 times per week for young men of age 20-25.
3. 3-5 times per week for young men of age 25-30.
4. 2-4 times per week for men of age 30-45,
5. 1-3 times per week for men of age 45-60,
6. 1-2 times every 10 days for men of age 60-70.
7. No more than once a week days after age 70
Lovemaking orgasms stimulate the pituitary to release oxytocin for a faster recovery; while masturbation may not help the pituitary to release enough oxytocin. Therefore, the masturbation ejaculation frequency should be limited to the low limit as possible as you can. If your ejaculation orgasm produces sexual exhaustion symptoms, your ejaculation frequency should be lower than the listed above. The actual ejaculation frequency is associated the refraction (recovery time) of the hypothalamus-pituitary-adrenal, -thyroid and -testicular axis. The energetic time (full recovery with powering up) for a man having a morning (8 AM) testosterone level at 350-400 nd/gl is about 7 days when his testosterone level reach its peak, over 500 ng/dl. If he keeps this ejaculation frequency, he will likely maintain his testosterone level around 450-550 ng/dl, thereafter. A man with a high testosterone level of 700 ng/dl or higher can re-erect the penis in a few minutes after ejaculating if his pituitary doesn't overshoot his prolactin level, but it doesn't mean he can ejaculate again. This is because the ability of penile re-erection can be associated with the dopamine nervous action on the pituitary oxytocin and prolactin release and the stimulation of testosterone, nitric oxide, prostaglandin E1 and prostaglandin E2 stimulation on the prostate and penile erectile nerves. Prostaglandin E2 can re-erect the post-ejaculating penis again when the oxytocin level is high and the prolactin level is not overshooting out of the range. The prostaglandin E2 induced erection usually accompanies a little pains in the prostate, urethra and penis. Even if you can re-erect your penis for sex again, the post-ejaculation elevating cortisol and prolactin will start to lock up the adrenal and testicular function to drop your DHEA and testosterone production few hours after the first ejaculation.
Like psychological stress or exercise-induced stress, sex-induced stress induces excessive cortisol, prolactin and norepinephrine/epinpehrine release to lock up the hypothalamus-pituitary-adrenal and -testicular axis during sex or few hours later after orgasm or ejaculation. The neuro-immune-endocrine responses to sex-induced stress can be delayed until cortisol starts to exert its effects on the adrenal cortex, prolactin on the pituitary-testicular axis, and norepinephrine/epinephrine and its induced prolstaglandin E2 overheat the hypothalamus, pituitary, adrenal glands, testicles (ovaries), prostate, liver, lungs, heart and pancreases (for a high glucogan release) via the alpha- and beta -andrenergic receptors. For the same reason, people with chronic stress, no matter from which sources, generally have a lower testosterone level. Over-trained athletes and soldiers and psychologically stressed-out persons are not exceptional. Testosterone and norepinephrine can positively or negatively interact each other through their receptors. Initially, testosterone induces norepinephrine release to give your arousal and heat, and then excessive norepinephrine with a high level of proactin and cortisol reduces testosterone release; on the other hand, without the inhibition effects of excessive prolactin and cortisol, norepinpehrine stimulates testosterone release via action on both alpha- and beta-andrenergic receptors in the adrenal and testicles (ovaries) when the testosterone level is too low. To avoid the inhibition effects of excessive prolactin and cortisol, you need a normal dopamine-hypothlamaus-pituitary-adrenal function. Any way, there are a lot of researches backing up the claim about the interaction among the nervous, immune and endocrine system:
Ref:
http://www.sciencedirect.com/science...=&_orig=search
&_sort=d&view=c&_acct=C0000502 21&_version=1&_urlVe rsion=0&_userid=10&md5=2ddd3a7 402479afca7ce03f4b59 238f9
http://hyper.ahajournals.org/cgi/con...tract/32/5/880
http://cat.inist.fr/?aModele=afficheN&cpsidt=2480820
http://www.scielo.br/scielo.php?scri...nrm=iso&tlng=e
http://www.biolreprod.org/cgi/content/abstract/40/3/541
http://www.popline.org/docs/0198/751348.html
http://hyper.ahajournals.org/cgi/reprint/17/6/1104.pdf
http://cat.inist.fr/?aModele=afficheN&cpsidt=15071810
http://www.ncbi.nlm.nih.gov/pubmed/1337237
http://endo.endojournals.org/cgi/con...ll/144/11/4923
The following research suggests the inflammatory cytokine IL-1beta and its induced prostaglandin E2 can stimulate the hypothalamus to induce release of norepinephrine, dopamine, and serotonin as a feedback control.
http://www.jneurosci.org/cgi/reprint/13/8/3574
This article suggest norepinephrine control the feedback of LH secretion in the hypothalamus-pituitary-testicular axis -
http://www.popline.org/docs/0188/761130.html
You will get more explanation in the following about the role of norepinephrine and epinephrine in the sexual arousal, orgasm responses, sexual exhaustion symptoms, and neuro-immune function.
Case Study - Destruction produced by Male over-ejaculation/over-masturbation or Female Over-Masturbation/excessive orgasm for no sexual orgasm. Reader:01/06/2002>
I tend to suffer from premature ejaculation. It varies how quickly it occurs but it almost always occurs before I desire it to. Until about 2 years ago, I masterbated almost daily (sometimes more than that). I am now 30 and have done so since age 12 or so. I suffer from depression although I currently take no medicine for it (I have taken medicine before). I have suffered from unknown lower back pain since I was 16. I also tend to have severe eye floaters and have been losing my hair since I was 23. I would appreciate your advice on how to overcome this problem.
Dr. Lin: 01/09/2002>
You have experienced the typical symptoms of sexual exhaustion due to over-masturbation since your puberty.
Over-masturbation or over-ejaculation over-discharges the brain's acetylcholine, dopamine, and serotonin nerves systems, resulting in brain's/nervous (pro-sympathetic, due to over-conversion of dopamine to norepinephrine and epinephrine for stress responses), liver, cardiovascular, kidney, and endocrine disorder, and then burns them out with chronically excessive norepinephrine/epinephrine/sympathetic nervous fires, the induced inflammatory hormone prostaglandin E2, glutamate, histamine, 3,4-dihydroxyphenylacetaldehyde (DOPAL - please read:
http://parkinsons.hopedigest.com/blo...nsons_disease), dihydroxyphenylacetic acid (DOPAC - please read
http://www.ohiolink.edu/etd/send-pdf...kent1164141349 and
http://www.ingentaconnect.com/conten...0004/art00023), 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL - please read:
http://pharmrev.aspetjournals.org/cgi/reprint/56/3/331 ) and 3,4-dihydroxyphenylglycol (DHPG - lease read:
http://pharmrev.aspetjournals.org/cgi/reprint/56/3/331 ). Your brain/neuro-endocrine and liver systems are like an over-discharged good-old-day car battery (overcharge causes chemical/mineral deposits on the electrodes of acid batteries made before 1980 and ruin them) which won't start the engine to perform recharging for itself. Some nervous cells are burned out or damaged by the nervous excitotoxicity and inflammation byproducts listed above. As a result of the exhaustion of your pituitary-adrenal and -testicular axis, the production of your androgen hormones (DHEA, androstenedione testosterone and DHT) and pituitary oxytocin become too low to support your neuro-immune function and to suppress the inflammatory hormone prostaglandin E2 release from your body - typically from your brain/head/neck, your pelvic organs, and your internal organs between your neck and pelvic cavity. The excess- orgasm or over-ejaculation induced prolactin, cortisol, norepinephrine and epinephrine, if excessive, can disable the pituitary-testicular (or -ovarian) axis for a few days or even months, leading to a long refraction time or a long-term sexual exhaustion and inflammation. Even, excessive prolactin, cortisol, noepinephrine and/or epinephrine in the bloodstream can induce excessive prostaglandin E2 release from the tissues. In fact, chronic elevation of epinephrine and prostaglandin E2 result in nervous excitotoxicity and cellular damage in the brain cells and the vagal or parasympathetic nerves in the liver, lungs, adrenal, heart, blood vessels, digestive system, pancreas, gallbladder, ovaries, uterus, cervix, testicles and prostate. Men also suffer from deficiency of the key semen chemicals such as potassium, zinc, calcium, magnesium, citric acid, androgen hormones (DHEA, androstenedione, testosterone and DHT), fructose, phosphorylcholine (for the brain/memory/vision/hearing/nervous sensing systems), spermine, prostatic acid phosphatase, free amino acids (most important ones includes GABA, glycine, agmatine and 5-HTP associated with brain/liver/adrenal/testicular functions, vision, hearing, sympathetic nervous control and mood) , prostaglandins (prostaglandins E1 and E3 for the elasticity and flexibility of tissues, nerves and blood vessels) and enzymes that support the androgen hormones and neurotransmitter syntheses. Unfortunately, the sexual exhaustion symptoms and inflammatory responses are a result of a low DHEA, androstenedione testosterone, DHT and/or oxytocin with a high or excessive level of prolactin, cortisol, norepinephrine and epinephrine, although you won't see a drop of your androgen hormones in couple hours right after the orgasm-induced prolactin and cortisol release. However, you may experience the pro-inflammatory neuro-immune responses to the sex-induced stress hormones norepinephrine and epinephrine during sex arousal and orgasm/ejaculation or even several days by activating a group of proinflammatory cytokines such as IL-1{alpha}, IL-1?, IL-6, TNF-{alpha}, IFN-{alpha}, and MIP-1 and protein kinases A and C in the the immune system via the alpha- and beta-adrenergic receptors in cells. The proinflammatory cytokines, acting as the endogenous pyrogen of desire fires, can trigger excessive norepinephrine-induced prostaglandin E2 production in the adrenergic receptors everywhere, from your scalp down to your toes. And then epinephrine will induces cutaneous mechanical hyperalgesia and sensitizes the dorsal root ganglion neurons via its action at a beta -adrenergic receptor and the effects of epinephrine are enhanced by both the inflammatory protein kinases A and C second-messenger pathways for enhancement of inflammatory responses. When the elevated prolactin, cortisol, norepinephrine and epinephrine constrict your arteries to your liver, kidneys, adrenal glands and testicles (ovaries for women) after sex, your adrenal and testicular (or ovarian) function will be disabled or shut down for many hours or days -
http://www.actionlove.com/#Ejaculati...terone Level
Suppression of androgen hormones production by excessive prolactin and cortisol, in conjunction with constriction of the arteries in the brain, liver, adrenal glands and testicles, will continue weakening your neuro-immune reaction for proinflammation, and prolong your recovery time and post-orgasm/post-ejaculation exhaustion and illness -
http://www.actionlove.com/#Sexually%...matory Pains,
%20Headaches%20and%20Hangover
Warning: sexual arousal, ejaculation or orgasm won't decrease your androgen hormonal level in the bloodstream immediately. If sexual arousal fires up your cortisol and prolactin to let your penis go limp (the sympathetic nervous Flight response to sexual stimulation and stress), you give up sexual activities immediately. This is because the elevation of prolactin and cortisol block your hypothalamus-pituitary-adrenal and -testicular axis which are supposed to fire up oxytocin, DHEA, androstenedione, testosterone and DHT production for your ongoing sexual excitation and orgasm. I consider that going limp during sex is a natural protection of your hypothalamus-pituitary-adrenal and -testicular axis. If you force yourself to ejaculation or orgasm after your experience the erectile dysfunction during sex, you will be in trouble. This is because, once androgen hormones in the bloodstream are used up and become too low to support your brain/nerves, internal organs and joints/muscles, you will start to experience the post-orgasm/post-ejaculation sexual exhaustion symptoms. Generally, these symptoms start to show up at about 3-8 hours after ejaculation or orgasm. The symptoms can last for 3-10 days until your brain's hypothalamus-pituitary-adrenal and-testicular axis start to kick in. During this suffering period, you have to rely on your skin/tissue's Cutaneous Hypothalamus-Pituitary-Adrenal (CHPA) function to assist post-ejaculation or post-orgasm recovery. Due to the link of the hypothalamus-pituitary-thyroid axis, you may also experience the symptoms associated with thyroid disorders. You will also like to experience hair loss too (
http://www.actionlove.com/extra/hailoss.htm ) For the functional equivalent of human hair follicles to the hypothalamus-pituitary-adrenal (HPA) axis, please read
http://www.fasebj.org/cgi/reprint/04-1968fjev1 (also
http://edrv.endojournals.org/cgi/reprint/21/5/457). When excessive sex stressed out your HPA, it also burned out your hair follicles, in particularly, with a high DHT, inflammatory hormone prostaglandin E2, cortisol, norepinephrine and epinephrine level and with a constriction of the blood vessels in your scalp when chronic prolactin, norepinephrine and epinephrine level run high. You can get more information form the home page of
http://actionlove.com for more detail. Using prescribed erectile drugs, the PDE-5 inhibitors, to assist erection for sex will mess up your neuro-endocrine function for sexual exhaustion.
Please also note that the extremely exhausted adrenal function can cause an extreme low level of DHEA, endophrin and cortisol. An abnormal cortisol level or a lack of endorphin indicates the adrenal function disorder, fatigue or excessive orgasm/ejaculation induced stress. Excessive orgasm or over-ejaculation can produce a transient shooting or cortisol and epinephrine and result in a long-term effect on the adrenal function, although the cortisol output may become too low or too high few days after sexual activities, with a constant elevation of epinephrine released from the hypothalamus and the adrenal medulla. It should be aware that prostaglandin E2 is an immune suppressor, as well as an nervous excitor. Excessive prostaglandin E2 in the bloodstream causes not only inflammatory, but also weak neuro-immunity. As a result, sexual exhaustion produce multiple symptoms which become UFO for the western doctors and medical societies since the western doctors and medical societies fail to realize the root of the problems, "enjoying too much sexual pleasure." If you don't go after the root of the problems, there is no way to solve the sexual exhaustion symptoms.
