From the post :
"How do we lose GHSR1a (Ghrelin receptor's) in the brain?
It appears that transient stimulation such as what one would get with GHRPs (GHRP-2, GHRP-6, Ipamorelin, Hexarelin) leads to a rapid desensitization and internalization of the receptors in the brain and this is a good thing. On the other hand administration of long acting Ghrelin-memetic (ibutamoren mesylate (MK-0677) likely leads to a habitual loss receptor status. This is a very bad thing."
O really ?
We are not rats !
The guy posted study reference and here is the study:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988273/
From the study:
"Using pharmacological agonism of GHSR-1a in non-stressed animals. Stress-induced changes in acylated ghrelin were observed at the nadir of the diurnal ghrelin cycle, suggesting that stress-related increases in ghrelin persist throughout the day. Because the half-life of acylated ghrelin is short [~30m (42)], we used MK-0677 (also known as ibutamoren mesylate), a highly selective GHSR-1a agonist with a half-life of at least 5–6h (43)"
And
"We systemically administered MK-0677 (MK: 5d) or saline (VEH: 5d) once a day for five consecutive days in non-stressed rats to determine whether repeated ghrelin receptor agonism in the absence of stress is sufficient to increase fear learning and whether HPA hormones may play a role in this effect."
Rats....