Not sure if this is just a coincidence or what but while researching on 4-oht I ended up on Promatrix Biotechnologies website. They carry a product, testobol, which is 4-oht and they make the exact same claims that this Promatrix character is claiming. I just thought it weird since the earlier post from Jerg points to where Promatrix claims to be a chemist / product developer for a supplement company and then I checked his profile where he claims to be a ceo for VPX retail. I just curious as to why someone whos a chemist / product developer for one company can or would run another companies store.
another board:
Now Im really geting confused because I keep finding a 4-oht that is an antiestrogen but it is referring to 4-hydroxy tamoxifen.
Checkout the new Antiestrogen article I posted in the Articles section.
db
But, Since I am a chemist/product deveolpmenter for a sports supplement company, I tend to believe Andro is a great product.
Heres some of the crap on the promatrix site. Pretty much the same **** bobo said but in a fashion where your average bodybuilder would be clueless while reading and probably think its the ****.ce4o of vpx retail
CLINICAL PHARMACOLOGY
General
The chemical term 4-HydroxyTestosterone THP Ether refers to the isomer: 4,17beta-dihydroxy-4-androstene-3-one tetrahydropyranyl ether. 4-HydroxyTestosterone THP Ether (4-OHT Ether) is the THP Ether derivative of 4-HydroxyTestosterone, which is a metabolite or derivative of the naturally occurring precursor hormone 4-Hydroxy-4-Androstenedione. 1 This compound concerns the isomer form of 4,17beta-dihydroxy-4-androstene-3-one tetrahydropyranyl ether.
4-HydroxyTestosterone THP Ether is an anabolic / androgenic compound that acts similar to real Testosterone. It does this by directly binding to the androgen receptor. 4-HydroxyTestosterone cannot directly convert to estrogen due its chemical configuration.
Efficacy Studies
The steroidal aromatase inhibitor, 4-HydroxyAndrost-4-ene-3,17-dione (4-OHA) and its metabolites, 4-HydroxyTestosterone (4-OHT), 3 beta,17-dihydroxy-5 alpha-androstan-4-one (metabolite A) and 3 alpha, 17-dihydroxy-5 beta-androstan-4-one (metabolite B) were evaluated as inhibitors of the human prostatic 5 alpha-reductase enzyme and for binding to the rat prostatic androgen receptor. 4-OHA and 4-OHT were weak inhibitors of 5 alpha-reductase with IC50 values of 15-29 microM. Metabolites A and B had no significant inhibitory activity. 4-OHA and metabolites A and B bound weakly to the androgen receptor. The binding affinities (RBA) relative to mibolerone (RBA = 100) were 0.085, 0.485 and 0.016, respectively. However, 4-OHT (RBA = 75) was a more potent binder than the endogenous androgen 5 alpha-dihydrotestosterone (RBA = 66). The ability of these metabolites, in particular 4-OHT, to bind to the androgen receptor may explain the in vivo androgenic activity of 4-OHA.3
Same **** different wrapper!!!References:
Poon GK, et al. Investigation of conjugated metabolites of 4-hydroxyandrost-4-ene-3,17-dione in patient urine by liquid chromatography-atmospheric pressure ionization mass spectrometry. Drug Metab Dispos. 1992 Nov-Dec;20(6):941-7.
Davies JH et al. Effects of 4-hydroxyandrost-4-ene-3,17-dione and its metabolites on 5 alpha-reductase activity and the androgen receptor. J Enzyme Inhib. 1992;6(2):141-7.
another board:
4-Hydroxytestosterone
By David Tolson
4-Hydroxytestosterone (4-OHT, 4,17beta-dihydroxy-4-androstene-3-one) is a legal steroidal compound that is relatively new to the market. Unlike prohormones, 4-OHT does not require enzymatic conversion to have an anabolic effect. It was first patented by G.D. Searle & Co. in 1955, but it did not reach the commercial market, and has recently become available as a dietary supplement. Chemically, 4-OHT is testosterone with a hydroxy group at the four position, making it most similar to the steroid clostebol, which has a chloro group at the four position. These two compounds are also very similar in effect.
4-OHT has moderate anabolic, mild androgenic, and anti-estrogenic properties. All in all, it can be expected to be associated with very few side effects, but this also comes at the expense of reduced anabolic activity. In the levator ani assay, 4-OHT is .65 times as anabolic and .25 times as androgenic as testosterone propionate. The reason that this compound has such low androgenic activity is that the modification at the 4 position prevents DHT conversion. In vitro, 4-OHT is actually a weak inhibitor of 5-alpha reductase. This weak androgenic effect is ideal for those who want to avoid or minimize side effects such as baldness, acne, and BPH. 4-OHT also has the benefit of having anti-estrogenic effects, which will eliminate chances of estrogen levels increasing, which can lead to side effects such as extra water retention and gyno. 4-OHT itself is a weak inhibitor of the aromatase enzyme which converts testosterone into estrogen, and a metabolite, 4-hydroxyandrostenedione (formestane), is a potent aromatase inhibitor. It should be emphasized that both androgenic and estrogenic effects can be beneficial for bodybuilders, it is simply a matter of how much side effects one wishes to tolerate.
Like most steroids, 4-OHT has low oral bioavailability and should be taken through a different route. Another reason why oral administration is not ideal is that, like clostebol, 4-OHT has a very short half-life. Those who inject usually use it every day or every other day totalling 300-700 mg weekly, stacked with other substances. Doses for transdermal administration should be in the range of 150-300 mg daily, and this is once again assuming one is stacking it with other steroids or prohormones. Using it as a standalone, optimal doses are probably considerably higher. 4-OHT has been most commonly stacked with 4-AD and 1-testosterone, although there are theoretical reasons why it may be beneficial to stack it with many substances – it will generally reduce estrogenic side effects, while adding anabolism without significantly contributing to androgenic side effects.
Now Im really geting confused because I keep finding a 4-oht that is an antiestrogen but it is referring to 4-hydroxy tamoxifen.
Checkout the new Antiestrogen article I posted in the Articles section.
db