CoolI'm looking at a different study, a different dosage, and a different sampling time.
CoolI'm looking at a different study, a different dosage, and a different sampling time.
Aspartic Acid Aspartate is a neurotransmitter in the brain, facilitating information from one neuron to another. Too much aspartate allows an influx of calcium into the brain cells, triggering an excessive amount of free radicals which kill the cells. Aspartate is referred to as an "excitotoxin" because of the nerve cell damage that it causes. Many chronic illnesses have been attributed to long term excitotoxin exposure, including multiple sclerosis, ALS, memory loss, hormonal problems, hearing loss, epilepsy, Alzheimer's disease, Parkinson's disease, hypoglycemia, dementia, brain lesions and neuroendocrine disorders. In 1971, Dr. John Olney, neuroscientist and one of the world's foremost experts on excitotoxins, informed G.D. Searle that his research had revealed that aspartic acid caused holes in the brains of mice.Well I'm not a PhD and I don't have a Masters - don't even have a batchelors.
I'm just a dumb old Visigoth who likes to dead lift and squat - I'm very horny but not too smart. I might have three brain cells that always occupied with either sex, food, or motorcycles.
Soooo ...
Here's the deal ...
Can someone explain this stuff in simple idiot's terms?
I looked up "NMDA RECEPTOR" on Wikipedia and the definition there made my head hurt.
So what are the possibilities here? Is it possible that DAA ...
A. Will make me stupider? (I know - prolly impossible but I have to ask)
B. Will make me an angry person ... or an excessively happy one ... or will it make me give my grandkids the "stink eye" and talk about how their generation sucks?
C. Will it turn me homo?
D. Will it make me fantasize about Rosanne Barr?
Basically - what's being alleged here as potential sides?
Anyone out there who can explain this in layman's terms?
i agree, it almost can be said with anything in the supplement world, some stuff works for ppl some people it doesn't, and it could have increased test, without bloodwork i'm not sure, all the tests show it does and a lot of people love the stuff, so i'm not doubting that, just didn't see any noticeable differences and in most cases, people see somethingWhat I'm simply getting at is that if your total test is say, 500 ng/dL. That's about middle of the road in terms of healthy test levels. If it increases by a third, you're total test going up by a third leads to 667 ng/dL, which is still about middle of the road in terms of healthy test levels.
In the end, it's only going to help increase test levels a bit. I think Bubsnt hit the nail on the head. It's an excitotoxin, which may raise test levels a little bit. I have a feeling that in a few years this substance will be like creatine monohydrate to a lesser degree. Some people love it, some people only get side effects, and some people are 'non-responders'.
Yeah, that's the catch 22.i agree, it almost can be said with anything in the supplement world, some stuff works for ppl some people it doesn't, and it could have increased test, without bloodwork i'm not sure, all the tests show it does and a lot of people love the stuff, so i'm not doubting that, just didn't see any noticeable differences and in most cases, people see something
ok, bob-i have a question for you. will it effect someone like me, who has been on trt for a considerable amount of time, differently than someone who starts out with normal range test level.What I'm simply getting at is that if your total test is say, 500 ng/dL. That's about middle of the road in terms of healthy test levels. If it increases by a third, you're total test going up by a third leads to 667 ng/dL, which is still about middle of the road in terms of healthy test levels.
In the end, it's only going to help increase test levels a bit. I think Bubsnt hit the nail on the head. It's an excitotoxin, which may raise test levels a little bit. I have a feeling that in a few years this substance will be like creatine monohydrate to a lesser degree. Some people love it, some people only get side effects, and some people are 'non-responders'.
unfortunatly that is where the whole problem lies.. No one know the safety of the product because it hasn't been tested.. One way or the other. Companies just picked it up because it increased gnrh, lh, fsh, and test.. And they expect me to test it for safety.. At least if I take meth it has years of studies and user feedback I can refer to...This really is a dose-dependency topic and until we have peer-reviewed proof of what an excitotoxic dose is... it's just a crap shoot.
Also, duration makes all the difference. If it's recommended to take DAA at 3g a day for 14 days but it takes 90 days for excitotoxicity to occur at this dose... you get my drift.
****, how much DAA is even bioavailable/excreted after oral ingestion of a 3g dose?
The studies just aren't there for anyone to feel 100% safe taking DAA - but as someone else mentioned a good deal of people take all sorts of narcotics that are known to be harmful.
What if DAA turns out to prevent all forms of brain cancer? No one has any clue at this point.
Pat has already chimed in. Provided us what he could.Where is Pat Arnold?
Furthermore, i think Dr. Dana Houser is doing a self study on DAA at 3gms a day over a 12 month period. Maybe he could chime in??
I've taken DAA with Clomid during pct. worked outwell, but i was also incorporating AI as a down stroke im my pct, so there was overlap. therefore, i can only speculate on DAA effects.
i need to run DAA solo for 14 days, and will post.
It might.ok, bob-i have a question for you. will it effect someone like me, who has been on trt for a considerable amount of time, differently than someone who starts out with normal range test level.
Dana's pretty hardcore, so it's tough to say.Pat has already chimed in. Provided us what he could.
I doubt Dinoii is taking brain biopsies looking for damage, but I could be wrong.
so becuase my natural test has and is shutdown, the benefits of daa could possibly be more beneficial? possibly act like hcg? the difference between someone on pct, and someone on trt taking daa, is that i am continuing to inject test while taking the daa. even though in both cases shutdown has occured, and a 1/3rd increase in natural test would be very beneficial, it seems to me that it would be even more advantageous on top of the injected test, no facts involved, just my thoughts.It might.
DAA occurs naturally within the body. If low amounts of the necessary enzyme for natural production exist, this might be a possible outlet for increasing test levels.
The purpose of any supplement is to obtain sufficient amounts of a desired substrate, which cannot be obtained by normal diet.
Look at ZMA. Unless you have a zinc or magnesium deficiency, the results are quite hampered.
Ha... that's why i put in the disclaimer!Dana's pretty hardcore, so it's tough to say.
It really depends on what metabolic mechanisms are limiting your natural test production. Throwing in injected test complexes things a bit, as well.so becuase my natural test has and is shutdown, the benefits of daa could possibly be more beneficial? possibly act like hcg? the difference between someone on pct, and someone on trt taking daa, is that i am continuing to inject test while taking the daa. even though in both cases shutdown has occured, and a 1/3rd increase in natural test would be very beneficial, it seems to me that it would be even more advantageous on top of the injected test, no facts involved, just my thoughts.
yeah, those people don't have a vested interest in any DAA products :wink1:http://www . lean bulk . com/forum/
ask-dr-houser/13065-daa-toxicity-hpta.html
Won't link so copy paste and put the spaces together.
or the bedroom:spankme:Yeah, that's the catch 22.
As a consumer, you don't actually care about increasing your test levels. It's whether or not they carry over to muscle/strength gains in the gym.
Aspartic Acid Aspartate is a neurotransmitter in the brain ... (snip)
That's my problem, it's bad genetics. There's not one person in my family that has large muscles.Thanks for answering my questions - I didn't understand all of it but I got enough of it to understand exactly what the big deal might be.
I will ease off the DAA I think - until there is more evidence on it's short and long term toxic effects. I use test boosters occasionally - but I really don't need to even though I'm 49 - my body still responds to training pretty well.
Which kind of "segways" into another discussion - and that is this crazy quest (by many) to reach a free testosterone level of 10,000 or something like that. I think people forget - that there is a lot more to the equation than testosterone ...
Now me - I have always responded to training - even if I eat badly - I can still build lean muscle. There have been times when I had to leave the gym (for whatever reason) and I stayed away for three, four years even - and I'd get fat as pig and you'd swear my muscle was totally gone - but whenever I came back I was able to quickly regain (within months) what I lost - and lose all the fat I had gained. It amazes me ...
I don't think I am the only one like this. I think a lot of people on this board are like me.
Does this mean I have high testosterone? Well, I don't know - because I have never paid attention to the blood tests when given one. But - I don't think so - because I have to WORK HARD to get down to 13% BF or lower. I can get under 18 no problem - but going under 13 is a trick for me!
I think it means something else.
I had a friend in the Navy who was the biggest horn-dog I've ever seen. He ****ed everything that moved - and when he wasn't ****ing with it he was yanking it - guy thought about nothing but sex. He couldn't help it - and felt a bit tormented by it - so he went to a psyche and the psyche actually tested his hormone profile. He came back on the high end for everything male related - which explained a lot concerning his sex drive.
And he was a lean mother ****er too - not an ounce of fat on him. However - when we'd drag him into the gym to get his mind off shagging - he'd work like hell, eat like hell - and not gain an ounce of muscle.
And I think - my dumb theory - is that the guy just didn't have it on the other end - the part where your muscles actually RESPOND to the presence of hormones and training and nutrition.
I think many guys have "so-so" test levels - but their muscles just respond disproportionally to the presence of test and training - and they get big because of that.
So I don't think testosterone is the "be all / end all".
Then again - I'm pretty stupid and prolly should go lift something right now before I start thinking I'm smart.
Don't feel bad - at least you have brains - you can always hire and boss someone to pick up any weight you need!That's my problem, it's bad genetics. There's not one person in my family that has large muscles.
People said they wanted Dr. Houser's opinion and there it is.yeah, those people don't have a vested interest in any DAA products :wink1:
Wish you would have quoted the rest.. His initial view is a little flawed.. Although I didn't read the whole thread.. But I see what you are saying.. Thanks for the link..People said they wanted Dr. Houser's opinion and there it is.
I saw no reason to quote it as I am not for your opinion or his and you already have a post with it on there. I was merely posting the link as a messenger. Short term sides IMO are nil and long term are reached for and inconclusive. People can make assumptions all they want one way or the other, until there are concrete facts, nobodies layman's opinion matters frankly.Wish you would have quoted the rest.. His initial view is a little flawed.. Although I didn't read the whole thread.. But I see what you are saying.. Thanks for the link..
As I stated earlier, someone could say the same thing about Methylenedioxypyrovalerone but taking that stance with substances on your body is you call.. That is what this thread is about. DAA is an exitotoxin and that is not an opinion.. Scientific fact regarding this has been posted multiple times.. The only thing even debatable is how much is too much.. And without human studies all we have is guesses. My point has been posted on this multiple times and I feel like I am being more argumentative than helpful at this point so I will sign off..I saw no reason to quote it as I am not for your opinion or his and you already have a post with it on there. I was merely posting the link as a messenger. Short term sides IMO are nil and long term are reached for and inconclusive. People can make assumptions all they want one way or the other, until there are concrete facts, nobodies layman's opinion matters frankly.
The experiments reported here show that the neurosteroid DHEA has powerful ameliorating effects on excitatory amino acid-induced neurotoxicity. This conclusion is strengthened by this effect being demonstrated both in vitro and in vivo for NMDA.
Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicityDHEA, together with DHEAS, is the most abundant steroid in the blood of young adult humans. Levels in humans decline with age and during certain types of illness or stress. We have found that DHEA(S) can prevent or reduce the neurotoxic actions in the hippocampus of the glutamate agonists N-methyl-D-aspartic acid (NMDA) both in vitro and in vivo or a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainic acid in vitro.
Pre-treatment with DHEA (10–100 nM for 6–8 h) protected primary hippocampal cultures from embryonic day 18 (E18) embryos against NMDA-induced toxicity (0.1, 1, 10, and 50 mM). DHEA added either with NMDA (1 mM) or 1 h later had lesser, but still significant, protective actions. DHEAS also reduced NMDA-induced toxicity (1 mM), although the lowest effective dose of DHEAS (100 nM) was higher than that of DHEA (10 nM).
DHEA (100 nM) protected cultured neurons against the neurotoxic actions of either AMPA (25 mM) or kainic acid (1 mM) as well. In vivo, s.c. pellets of DHEA, which resulted in plasma levels that resembled those in young adult humans, protected hippocampal CA1y2 neurons against unilateral infusions of 5 or 10 nmol of NMDA.
Because the release of glutamate has been implicated in the neural damage after cerebral ischemia and other neural insults, these results suggest that decreased DHEA levels may contribute significantly to the increased vulnerability of the aging or stressed human brain to such damage.
There are many things debatable one of which being whether or not DAA is toxic in ANY amount, especially by ingesting small amounts. There are NO tests that prove this. There are only YOUR theories. SO you can post the same thing again and again and it still does not matter one little bit. You are making a guess. Just because it is an agonist does not mean it causes any type of neurotoxicity.As I stated earlier, someone could say the same thing about Methylenedioxypyrovalerone but taking that stance with substances on your body is you call.. That is what this thread is about. DAA is an exitotoxin and that is not an opinion.. Scientific fact regarding this has been posted multiple times.. The only thing even debatable is how much is too much.. And without human studies all we have is guesses. My point has been posted on this multiple times and I feel like I am being more argumentative than helpful at this point so I will sign off..
Thanks everyone for the input!
I ain't yo daddy!!!so basically the general consensus of this thread is that i should stop taking my daa? even if at the moment im having no sides?
LOL... so daa could some day cause parkinsons or some type of neurological disorder?I ain't yo daddy!!!
I don't think you would feel these sides brother. You would probable just end up in a old folk home at a early age. If all that's said is even true but I will not be taking my chances with this one.
Yes, I stopped the day I was made aware of the possible sides. I can't rely on my good looks forever so I need my brain, lol. Try to skim thru the posts i know it's a lot but it will be worth your time my friend.LOL... so daa could some day cause parkinsons or some type of neurological disorder?
im already a recovering addict... lol ive put plenty of holes in my brain already.... so on one hand, i could say fu*ck it, but that never seems to work out the way i plan......
if this stuff is actually potentially dangerous for my brain(or whats left of it), i think i should stop
i read ur first post in this thread when u started it... im assuming you stopped taking it?
thanks... (i must spread some reputation around)Yes, I stopped the day I was made aware of the possible sides. I can't rely on my good looks forever so I need my brain, lol. Try to skim thru the posts i know it's a lot but it will be worth your time my friend.
Actually it still is just your opinion no matter how many times you repeat it.That is what this thread is about. DAA is an exitotoxin and that is not an opinion.. Scientific fact regarding this has been posted multiple times..
I know meatheads that make test in their basement, lolneuroscientist on anabolicminds............
why do u even have any interest in daa... i bet you could make test in your sink..
And bulbine is safer??? There is probably less known about thatYes, I stopped the day I was made aware of the possible sides. I can't rely on my good looks forever so I need my brain, lol. Try to skim thru the posts i know it's a lot but it will be worth your time my friend.
Ya know what **** it all I eat 3 pounds of raw meat a day and pop stims like candy. I'm ****ed anywayAnd bulbine is safer??? There is probably less known about that
I don't have an interest in DAA and am not taking it or endorsing any company that produces it. I simply saw somebody misquoting scientific studies and asked them if they could produce another source and it blew up from there.neuroscientist on anabolicminds............
why do u even have any interest in daa... i bet you could make test in your sink..
You've been nothing but great with me and I appreciate it. I don't think DAA does as much as some propose it does in regards to test production and it may cause problems like increased anxiety. There are plenty of other products out there.Alek, I'm just trying to play safe. I don't think at any time I was rude or unprofessional with you so I don't think you're talking about me, lol. I do know, i don't know how to spell half the sh!t we're talking about let alone even know what any of it means. Which is the reason I have stopped supplementing with DAA.
PM is on it's way. Even tho the chance of me comprehending it is close to none...
How much were you taking. I think people should start at a very small dose and slowly titrate up.I did some research before I bought a tub from NP and thought I would give it a run to see if it lived up to the hype.
I got a wierd headache the seemed to be in the center of my brain, it was constant - not overpowering but strong enough to know something was not right. That was from day one.
The DAA is now on the shelf until further notice.
Adding 200mg of B6 to that stack would be a good idea.How much were you taking. I think people should start at a very small dose and slowly titrate up.
I am planning to run DAA on-cycle with my Havoc and tren cycle to see if it helps shutdown. Will be running it with p5p, b12 and IGF-2 (for l-dopa source).
this is not like taking an exogenous steroid which causes suppression while you are taking it and then when you stop you stay suppressedmy biggest concern is does test levels fall off the chart after using. lol-do you need a pct for daa?
It is actually good science. No studies have been performed for the safety in humans.. DAA is a PROVEN EXITOTOXIN with agonist activity at the NMDA receptor.. And NMDA toxicity is not someones theory but proven science.. You are saying to ignore both anecdotal reports and available scientific literature because it is not "fact." ]
but is there any evidence we are NOTthe term excititoxin is really a misnomer. It assumes that all agonists of the NMDA receptor are neurotoxic no matter what the concentration. That obvoiusly is not true
Lack of NMDA agonists would surely **** your brain up as you can well imagine. Too much can be kill neurons. The question here is are we reaching the level of d-aspartic acid in the brain that is dangerous. There is no evidence that we are
first of all, the fact that he is a neuroscientist is probably why he is interested in DAA.. Particularly because DAA involves his exact area of specializationneuroscientist on anabolicminds............
why do u even have any interest in daa... i bet you could make test in your sink..
no there isnt. but that essentially can be said for the majority of supplement ingredients out there. Even some drugs, which have only been studied for relatively short term safetybut is there any evidence we are NOT
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