The gut secretes two important hormones, cholecystokinin (CCK) and glucagon-like peptide-1 (GLP-1), that are also known as "satiety hormones", as they give us a sense of food satisfaction and fullness, usually experienced after meals.
CCK, also known as the "fee-full" hormone, is a peptide hormone that can stimulate the synthesis of fats and proteins. CCK is produced in the intestines when we eat fats and proteins, and signals the brain to stop eating when CCK levels are elevated. Compounds that can stimulate CCK release include EGCG in Green Tea, L-Phenylalanine (also a neurotransmitter booster), Phenylethylamine (PEA), Phosphatidylcholine, Korean Pine Nut (Pinolenic Acid), Kidney Bean (Phaseolus vulgaris), and so on. Phenylalanine, by the way, can be converted into phenylethylamine.
Glucagon-like peptide-1 is tightly connected with fullness and satiety, and is secreted in response to fat and carbohydrate ingestion. Slows food absorption in the gut, thus promoting fullness and satiety and desire for further food intake.
Phenylethylamine (PEA) is a potent nautral appetite suppressant and weight loss agent. PEA is better than amphetamines, as PEA does not increase the rate of eating experienced in amphetamine-based pathways. Furthermore, PEA increases dopamine levels, leading to an increase in physical activity and decreased food intake. Something else: PEA boosts serotonin activity, further leading to decreased food intake.
Synephrine is a direct alpha-1 adrenergic agonist. Alpha-l adrenergic agonists stimulate thermogenesis and decrease appetite.
Theobromine, a methlyxanthine, has a similar, but smaller-scale, effect than caffeine. Caffeine, hordenine, theobromine, and PEA act synergistically to potentiate decreased appetite and thermogenesis.
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