Your opinions: Silymarin during or after a methyl cycle?
- Thread starter Chippewa
- Start date
UNDERTAKER
Well-known member
this has been talking about, do a search. I dont think you will find a definitive answer as everyone has different opionions on the subject.
strangebrew
New member
Take it year round.
t_dot_porkchop
Board Supporter
i run it heavy BEFORE a methyl cycle and then again during PCT. not at all during the cycle.
bioman
Well-known member
Information I have read on Milkthistle and NAC show its best used while the liver is being exposed to toxins(ie Acetominifen, M1T) by aiding the liver and its metabolism to breakdown toxins while lessening the damage those toxins do to the liver.
I believe it was Big Cat who mentioned that increasing the liver's ability to break down toxins might hinder gains while on cycle. This is pure hypothesis and to me it seems like myself and numerous others get and keep the same gains as when we did not use MT and NAC.
IMO it is foolish to hope that MT/NAC/RALA will REPAIR damage brought on by M1T when there is little evidence showing that this is what MT/NAC are for. Evidence points to them being protectants not magical liver cell replacement pills.
As an aside, the level to which NAC/MT can actually protect the liver from harsh methyls like M1T is not fully understood. We've seen very high liver values even from individuals who used them on cycle...so be cautious.
Also, research has pointed out that inconsistent use of MT/NAC is actually WORSE than either not taking it all or taking it consistently everyday. In other words, while on cycle DO NOT forget to dose your MT/NAC.
I believe it was Big Cat who mentioned that increasing the liver's ability to break down toxins might hinder gains while on cycle. This is pure hypothesis and to me it seems like myself and numerous others get and keep the same gains as when we did not use MT and NAC.
IMO it is foolish to hope that MT/NAC/RALA will REPAIR damage brought on by M1T when there is little evidence showing that this is what MT/NAC are for. Evidence points to them being protectants not magical liver cell replacement pills.
As an aside, the level to which NAC/MT can actually protect the liver from harsh methyls like M1T is not fully understood. We've seen very high liver values even from individuals who used them on cycle...so be cautious.
Also, research has pointed out that inconsistent use of MT/NAC is actually WORSE than either not taking it all or taking it consistently everyday. In other words, while on cycle DO NOT forget to dose your MT/NAC.
bioman
Well-known member
I've read this from research summaries so I don't know the answer off hand. Maybe Dr D or some other knowledgable person can elaborate. Article was at lef.org under acetiminiphen poisoning...backed up by studies.
My guess is that for NAC you are basically supplying the liver with glutathione which is fuel for the liver to do its thing. This might cause a bit of a negative feedback mechanism so stopping NAC supplementation might leave the liver with no or very little glutathione to work with temporarily. Taking it away in the middle of a toxic exposure would thus be bad.
Milk thistle works along so many pathways that I have no idea how it actually works to begin with.
My guess is that for NAC you are basically supplying the liver with glutathione which is fuel for the liver to do its thing. This might cause a bit of a negative feedback mechanism so stopping NAC supplementation might leave the liver with no or very little glutathione to work with temporarily. Taking it away in the middle of a toxic exposure would thus be bad.
Milk thistle works along so many pathways that I have no idea how it actually works to begin with.
