For fat loss, I would up the dosage, for therapeutic benefits I would stay at a lower dose. The biggest benefit I get is that I still feel energized in the morning after a workout(night before) as opposed to feeling lethargic as a result of over production of cortisol from work, stress, over-training, under-eating, eating too many processed foods, etc. Not that I always over train and under eat, but it happens sometimes. Normal cortisol levels are good as we need it to survive, but too much is bad. I noticed it also keeps my blood sugar in check.