Which would you think inhibits estrogen more, Epiandro high does or 6 oxo high dosed?

JoePaul39

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Have recently acquired some 6 oxo and so thinking of selling my oral Epiandro as I believe 100 mg transdermal 6 OXO would inhibit estrogen more and create more dht than 1000 mg oral Epiandro. Opinions? I say this because 6 OXO unlike Epiandro has an actual study behind it showing it does indeed significantly reduce estrogen and raise dht, however I know epiandro is known to do this as well.
 
xR1pp3Rx

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well one is an AI sooo...

epiandro is not the AI.
 

JoePaul39

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well one is an AI sooo...

epiandro is not the AI.
Agreed. Just thought since Epiandro is dht based it can function as a weak AI in purpose though it is not an actual AI.
 
xR1pp3Rx

xR1pp3Rx

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DHT can act as a weak AI. it can also offset the epitest ratio and thus keep estrogens a bit lower. but that is nothing like a suicidal inhibitor.

think of DHT as more of an antagonist to estrogen receptors. I have always felt this would be the more accurate theory.

if it were that stronk you would hear about everyone using a DHT analogue crashing their estrogen, yet that clearly is not the case. and we dont even need to touch on how many analogues to DHT are out there.
 

JoePaul39

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DHT can act as a weak AI. it can also offset the epitest ratio and thus keep estrogens a bit lower. but that is nothing like a suicidal inhibitor.

think of DHT as more of an antagonist to estrogen receptors. I have always felt this would be the more accurate theory.

if it were that stronk you would hear about everyone using a DHT analogue crashing their estrogen, yet that clearly is not the case. and we dont even need to touch on how many analogues to DHT are out there.
Thanks for the useful info. Always learning something new on this board which is why I love it!
 

JoePaul39

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Well I know Apex’s 6 OXO is legit because I am pissing constantly from the DHT elevation enlarging my prostate (I’m 44) even with a full ML of Helios 100 and mg Cialis which usually does the trick to stop that even when on cycle with DHT steroids like Epistane. May have to add some Super Beta ProstAte or try 2 ML Helios 100 which I have never done that high of a dosage before.
 

johnny412

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DHT can act as a weak AI. it can also offset the epitest ratio and thus keep estrogens a bit lower. but that is nothing like a suicidal inhibitor.

think of DHT as more of an antagonist to estrogen receptors. I have always felt this would be the more accurate theory.

if it were that stronk you would hear about everyone using a DHT analogue crashing their estrogen, yet that clearly is not the case. and we dont even need to touch on how many analogues to DHT are out there.
list of suicide inhibitors? i think arimistane is one
 

JoePaul39

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list of suicide inhibitors? i think arimistane is one
I don’t think it as strong as 6 OXO, but have never run it. Plus 6 OXO raises free t and not sure if Arimistane does that too.
 

johnny412

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I don’t think it as strong as 6 OXO, but have never run it. Plus 6 OXO raises free t and not sure if Arimistane does that too.
just asking about suicide inhibitors lol
 
xR1pp3Rx

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any aromatase inhibitor would be considered "suicidal"

SERMs occupy an estrogen receptor, allowing estrogen to still circulate in the blood basically waiting to be filtered in piss and excreted.

aromatse inhibitors keep estrogen from being created. thus termed suicidal

from wiki:
In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition
 
KvanH

KvanH

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any aromatase inhibitor would be considered "suicidal"

SERMs occupy an estrogen receptor, allowing estrogen to still circulate in the blood basically waiting to be filtered in piss and excreted.

aromatse inhibitors keep estrogen from being created. thus termed suicidal

from wiki:
In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition
I think what we usually mean by suicidal AI is an irreversible AI, where the compound binds to aromatase entzyme and kind of 'kills it off', like 6-oxo, Exemestane does. Not suicidal AI's like Anastrozole, Letrozole bind to aromatase entzyme, but only occupy it for a while, and after the AI leaves the system, the same aromatase entzymes are again 'active'.
 

JoePaul39

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any aromatase inhibitor would be considered "suicidal"

SERMs occupy an estrogen receptor, allowing estrogen to still circulate in the blood basically waiting to be filtered in piss and excreted.

aromatse inhibitors keep estrogen from being created. thus termed suicidal

from wiki:
In biochemistry, suicide inhibition, also known as suicide inactivation or mechanism-based inhibition
I think some of the confusion with 6 OXO comes in to play because unlike Arimistane and other AI’s it is considered an AI AND a prohormone is it not?
 
xR1pp3Rx

xR1pp3Rx

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I think what we usually mean by suicidal AI is an irreversible AI, where the compound binds to aromatase entzyme and kind of 'kills it off', like 6-oxo, Exemestane does. Not suicidal AI's like Anastrozole, Letrozole bind to aromatase entzyme, but only occupy it for a while, and after the AI leaves the system, the same aromatase entzymes are again 'active'.
accurate.
 
xR1pp3Rx

xR1pp3Rx

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I think some of the confusion with 6 OXO comes in to play because unlike Arimistane and other AI’s it is considered an AI AND a prohormone is it not?
according to PA It is devoid of any direct hormonal or prohormonal activity (androgenic or estrogenic). Its actions likely are similar to other AIs in that it raises LH and lowers SBGH, just to a higher degree. I think it's probably looked at like a PH because its powerful effects. (the Baylor study showed a 90% increase in free test and significant rises in exogenous DHT/test) I can see why people say that but I'm not sure its an accurate assessment
 

JoePaul39

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according to PA It is devoid of any direct hormonal or prohormonal activity (androgenic or estrogenic). Its actions likely are similar to other AIs in that it raises LH and lowers SBGH, just to a higher degree. I think it's probably looked at like a PH because its powerful effects. (the Baylor study showed a 90% increase in free test and significant rises in exogenous DHT/test) I can see why people say that but I'm not sure its an accurate assessment
Do AIs typically increase DHT as the mechanism to reduce the estradiol?
 
xR1pp3Rx

xR1pp3Rx

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Do AIs typically increase DHT as the mechanism to reduce the estradiol?
maybe a little after a long hormonal cascade. like we see with use of pretty much any AI, in a direct result of lower estrogen, the body tries to balance the hormonal axis. in basic terms the body sense the higher testosterone and begins to metabolize both it and estrogen. this kind of why we hear of rebound gyno.
sometimes guys use a SERM that has a bunch of estrogen "managed". effectively nullifying its effects at the receptor level. this estrogen is still in circulation in a lot of instances. in particular any methyl-estro. when they quit using the SERM however, all the sudden the body senses the elevated estrogen and again, in an attempt to balance the HTPA, it raises test. test>produces a ton of aromatase to counter the extra testosterone and if the person isn't on top of things the already high estrogen combined with a bunch of test and aromatase, well it just a viscous out of control rollercoaster.

so back to your question, one of the things that happens to test is it conversion to DHT. right? so... after we pieced it all together above, it does in the end cause total hormonal manipulation in the big picture kind of way. does that make any sense?
 
xR1pp3Rx

xR1pp3Rx

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I wasn't disagreeing with your post above ... I just didn't have time to read it right now.
:)
I didnt think you were at all. in fact in the terms of his question we are both on point

your statement is the basix principal: what it does.

mine refers to the entire picture down stream as a result beyond the initial effect of the AI. the effects resulting from its effects ;)
 
xR1pp3Rx

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I wasn't disagreeing with your post above ... I just didn't have time to read it right now.
:)
OH and my statement on checks and balances was not directed at you~ it was a final statement to the one I said before yours! i was too lazy to edit and your post flew in between the two.

totally hilarious.
 
Renew1

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OH and my statement on checks and balances was not directed at you~ it was a final statement to the one I said before yours! i was too lazy to edit and your post flew in between the two.

totally hilarious.
Thanks.
I still haven't read it.
... On the road....
 

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