When your estrogen is high and your exhibiting signs of high estrogen, which you will only know for certain through bloodwork. But with that being said, inhibit e shouldn't be able to crush your estrogen like a pharmaceutical AI. So you can probably play around with it.
Honestly your question has no context to it, you didn't give any information at all or even say what you're taking that might cause your estrogen to be high. So with the information you provided there is no answer to your question