What is P5P and why do I need it?

MySTeek

MySTeek

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Vit B6 (as Pyridoxal-5-Phosphate)

Overview:
P-5-P is the most active form of vitamin B6, having significant nootropic effects. P-5-P plays an essential part in mood, memory formation, and executive functions.

Scientific Name:
(4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate

Mechanisms:

Essential for cellular energy metabolism[1]
Increases mental and physical energy, improves neuronal communication[2]
Prevents age-associated neuronal damage[3]
Involved in the synthesis of acetylcholine, dopamine, serotonin, noradrenaline and melatonin[4,5]
Important role in executive functions, memory formation, mood regulation, focus, motivation, and sleep regulation[5,6]
More Info:

Intro: https://www.nootropedia.com/vitamin-b6/
Studies: https://examine.com/supplements/Vitamin+B6/

Articles: http://www.livestrong.com/article/474532-what-are-the-health-benefits-of-p5p/

References

[1] Clayton PT (2006). B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis, 29(2-3):317-26. doi: 10.1007/s10545-005-0243-2
[2] Ebadi M, et al (1990). Hippocampal zinc thionein and pyridoxal phosphate modulate synaptic functions. Ann N Y Acad Sci, 585:189-201. doi: 10.1111/j.1749-6632.1990.tb28053.x
[3] Campanini B, et al (2013). Serine racemase: a key player in neuron activity and in neuropathologies. Front Biosci (Landmark Ed), 18:1112-28. doi: 10.2741/4167
[4] Yoshimura T, Goto M (2008). D-amino acids in the brain: structure and function of pyridoxal phosphate-dependent amino acid racemases. FEBS J, 275(14):3527-37. doi: 10.1111/j.1742-4658.2008.06516.x
[5] Deijen JB et al (1992). Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl), 109(4):489-96. doi: 10.1007/BF02247729
[6] Ebadi M (1981). Regulation and function of pyridoxal phosphate in CNS. Neurochem Int ;3(3-4):181-205. doi: 10.1016/0197-0186(81)90001-2
Source: https://www.neurohacker.com/vit-b6-as-pyridoxal-5-phosphate

Where do you get it? Millennium Sport Technologies already figured it out for you. The following list of MST goodies contain P5P and all their glorious nootropics potential!

1. Electrolytes!
https://millenniumsport.net/products/athlytes-atp/

2. King of multivitamins!
https://millenniumsport.net/products/mvp-365/

3. The ultimate Dream and Cognitive enhancer!
https://millenniumsport.net/products/zmk/

All-together and on their own, they make for a very wise choice. Go eat your veggies and take your B vitamins!
ryanp81 thank you for the reminder!
 
TheVenom

TheVenom

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Interesting, I'll be making room for MVP once I'm free of other obligations. ;)
 
MySTeek

MySTeek

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