what is p-slin?

808shredded

Active member
Is p-slin similar to anabolic pump? Is it used for bulking, cutting, recomp? What supps/ph is good to stack it with?
 
R1balla said:
a simple google search would do you wonders
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U might be correct, but as a highly respectable member of this forum that adores USPLabs; you could've told him the answer.
 
808shredded said:
Is p-slin similar to anabolic pump? Is it used for bulking, cutting, recomp? What supps/ph is good to stack it with?
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Capped P-Slin was a blend composed of highly concentrated Tannins Complex™ (Extract Engineered From Lagerstroemia Speciosa) and Gymnemic Complex (Herbal Engineered From Gymnema Sylvestre), and was designed to be consumed about 15-20 minutes before consumption of up to 100g of carbohydrates. One of the best glucose-disposal agents ever developed, P-Slin is no longer manufactured. However, a bulk version (Bulk P-Slin) that contains the Tannins Complex and is equally popular exists and is back in stock since this afternoon:


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On its part, Anabolic Pump contains a proprietary blend of Phellodendron (bark) and Crepe Myrtle (Lagerstroemia speciosa (stem) - also in P-Slin/Bulk P-Slin), and induces preferential glucose and nutrient uptake in skeletal muscle cells as opposed to fat cells, while supporting fat loss via the inhibition of adipogenesis and adipose differentiation, completely independent of insulin. Meals of up to 70g of carbohydrate can be consumed about 15-20 minutes after Anabolic Pump intake.


Both Bulk P-Slin and Anabolic Pump can be used in bulking, cutting, and recomp scenarios.

 
P slin and anabolic pump are basically the same? Or do the two extracts of the same ingredient act differently?
 
mattrag said:
P slin and anabolic pump are basically the same? Or do the two extracts of the same ingredient act differently?
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There are two key differences between Bulk P-Slin and Anabolic Pump. First, Bulk P-Slin contains a much higher concentration and amount of the common ingredient, Lagerstroemia speciosa. Second, Anabolic Pump contains Phellodendron (not found in PSlin), a compound whose key bioactive constituent is berberine, an isoquinoline derivative alkaloid with multiple pharmacological effects that include significant insulin-sensitizing, glucose-disposal, anti-hyperglycemic, anti-adipogenic, and other effects. More specifically, berberine has been shown to antagonize the hyperglycemic action of glucose and the gluconeogenic (new-glucose-producing) action of alanine, as well as ameliorate insulin resistance (by increasing cellular insulin sensitivity). While these results are impressive, what is more impressive is that berberine induces these effects without raising insulin levels!

Beyond reducing fasting blood glucose levels, berberine lowers blood plasma triacylglycerol (stored fat) and free fatty acid levels, reduces levels of C-reactive protein (an important marker for chronic inflammation) and cholesterol, ultimately leading to improved peripheral insulin sensitivity and nutrient uptake.

Furthermore, berberine stimulates the up-regulation of the expression of the enzyme 5'-adenosine monophosphate-activated protein kinase (AMPK) [a key enzyme and "molecular master switch" that plays a critical role in cellular energy homeostasis], mitogen-activated protein kinase (MAPK), p38 MAPK (for insulin-independent glucose uptake), peroxisome proliferator-activated receptor alpha (PPARa), uncoupling protein-2 (UCP-2), as well as hepatic (liver) nuclear factor 4 alpha (HNF4a). The activation of AMPK leads to inhibition of fatty acid synthesis (production) and increased fatty-acid (beta) oxidation in the liver and adipocytes (fat cells), as well as the synthesis of cholesterol in the liver. Conversely, it down-regulates the expression of peroxisome proliferator-activated receptor gamma (PPARg), PPARg cofactors, as well as resistin. In other words, berberine beneficially modulates glucose and lipid metabolism via multiple molecular mechanisms.

One mechanism through which berberine induces its anti-hyperglycemic activity is by acting as a potent competitive inhibitor of the human protein tyrosine phosphatase 1B (h-PTB1B). PTB1B is a negative regulator (inhibitor) of insulin signaling (or signal transduction), so that PTB1B levels are high in insulin-dysfunctional states. In other words, PTB1B down-regulates insulin action and insulin sensitivity in skeletal muscle and fat cells. Consequently, by inhibiting h-PTB1B, berberine allows the restoration of cellular insulin sensitivity and reduces plasma glucose levels.

In terms of the inhibition of lipid metabolism, berberine accomplishes this by blocking adipogenesis (new-fat formation) in fat cells via inhibition of PPARg and C/ERB alpha, and by activating PPARa. Furthermore, still on inhibition of lipid metabolism, berberine reduces GLUT4 mRNA expression in fat cells and also reduces the expression of multiple lipogenic and adipogenic genes in adipocytes (fat cells).
 
808shredded said:
So in a cutting diet, one can consume higher carb intake while on p-slin?
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P-Slin can allow higher consumption of carbohydrates in a cutting cycle with considerably less fat gain than would otherwise have been possible without P-Slin. This, no doubt, is dependent on the amount of carbohydrates consumed per session.
 
M.Soleto said:
I want to try pslin and this anabolic pump and will see.
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Awesome. Would appreciate your feedback when you do. Thank you for the support!
 
strategicmove said:
There are two key differences between Bulk P-Slin and Anabolic Pump. First, Bulk P-Slin contains a much higher concentration and amount of the common ingredient, Lagerstroemia speciosa. Second, Anabolic Pump contains Phellodendron (not found in PSlin), a compound whose key bioactive constituent is berberine, an isoquinoline derivative alkaloid with multiple pharmacological effects that include significant insulin-sensitizing, glucose-disposal, anti-hyperglycemic, anti-adipogenic, and other effects. More specifically, berberine has been shown to antagonize the hyperglycemic action of glucose and the gluconeogenic (new-glucose-producing) action of alanine, as well as ameliorate insulin resistance (by increasing cellular insulin sensitivity). While these results are impressive, what is more impressive is that berberine induces these effects without raising insulin levels!

Beyond reducing fasting blood glucose levels, berberine lowers blood plasma triacylglycerol (stored fat) and free fatty acid levels, reduces levels of C-reactive protein (an important marker for chronic inflammation) and cholesterol, ultimately leading to improved peripheral insulin sensitivity and nutrient uptake.

Furthermore, berberine stimulates the up-regulation of the expression of the enzyme 5'-adenosine monophosphate-activated protein kinase (AMPK) [a key enzyme and "molecular master switch" that plays a critical role in cellular energy homeostasis], mitogen-activated protein kinase (MAPK), p38 MAPK (for insulin-independent glucose uptake), peroxisome proliferator-activated receptor alpha (PPARa), uncoupling protein-2 (UCP-2), as well as hepatic (liver) nuclear factor 4 alpha (HNF4a). The activation of AMPK leads to inhibition of fatty acid synthesis (production) and increased fatty-acid (beta) oxidation in the liver and adipocytes (fat cells), as well as the synthesis of cholesterol in the liver. Conversely, it down-regulates the expression of peroxisome proliferator-activated receptor gamma (PPARg), PPARg cofactors, as well as resistin. In other words, berberine beneficially modulates glucose and lipid metabolism via multiple molecular mechanisms.

One mechanism through which berberine induces its anti-hyperglycemic activity is by acting as a potent competitive inhibitor of the human protein tyrosine phosphatase 1B (h-PTB1B). PTB1B is a negative regulator (inhibitor) of insulin signaling (or signal transduction), so that PTB1B levels are high in insulin-dysfunctional states. In other words, PTB1B down-regulates insulin action and insulin sensitivity in skeletal muscle and fat cells. Consequently, by inhibiting h-PTB1B, berberine allows the restoration of cellular insulin sensitivity and reduces plasma glucose levels.

In terms of the inhibition of lipid metabolism, berberine accomplishes this by blocking adipogenesis (new-fat formation) in fat cells via inhibition of PPARg and C/ERB alpha, and by activating PPARa. Furthermore, still on inhibition of lipid metabolism, berberine reduces GLUT4 mRNA expression in fat cells and also reduces the expression of multiple lipogenic and adipogenic genes in adipocytes (fat cells).
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Thanks!
Berberine is amazing.
 
strategicmove said:
There are two key differences between Bulk P-Slin and Anabolic Pump. First, Bulk P-Slin contains a much higher concentration and amount of the common ingredient, Lagerstroemia speciosa. Second, Anabolic Pump contains Phellodendron (not found in PSlin), a compound whose key bioactive constituent is berberine, an isoquinoline derivative alkaloid with multiple pharmacological effects that include significant insulin-sensitizing, glucose-disposal, anti-hyperglycemic, anti-adipogenic, and other effects. More specifically, berberine has been shown to antagonize the hyperglycemic action of glucose and the gluconeogenic (new-glucose-producing) action of alanine, as well as ameliorate insulin resistance (by increasing cellular insulin sensitivity). While these results are impressive, what is more impressive is that berberine induces these effects without raising insulin levels! ...
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Awesome post. This is how customer service should be done.

Ike, out of interest how would you approach P-Slin and AP in terms of application i.e. in what circumstances would P-Slin be a better option than AP and vice versa?
 
bdcc said:
Awesome post. This is how customer service should be done.

Ike, out of interest how would you approach P-Slin and AP in terms of application i.e. in what circumstances would P-Slin be a better option than AP and vice versa?
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Thank you, Ben! (Bulk) P-Slin can handle larger carbohydrate loads, in the range of 60-120g, at standard doses, or somewhat higher at increased doses. It is incredibly effective before a carbohydrate-containing pre-workout meal, disposes glucose efficiently and delivers real "food pumps". If fat-loss is not the primary concern, and if carbohydrate consumption is more in the high range, (Bulk) P-Slin is unmatched. Anabolic Pump on the other hand lends itself to more versatility. In particular, it can be used as a powerful fat-loss tool (when carbohydrate consumption is limited to 30-35g per dose of Anabolic Pump), can be part of a fat-loss stack, or can be used in a standard everyday fashion during its cycle or in lean-bulk or controlled-bulking scenario with normal carbohydrate consumption of up to 60-70gr. Its beauty is its ability to stimulate glucose uptake in skeletal muscle cells, at the expense of fat cells, thanks to the molecular mechanisms I enumerated earlier. Anabolic Pump and (Bulk) P-Slin can also be stacked. In this case, (Bulk) P-Slin is used for the largest carbohydrate meal during the day, while Anabolic Pump can be used for two othe carbohydrate-containing meals. They can also be used during before cheat meals.
 
I just wanted to add some information that was shared with me by Mulletsoldier (the other fine product educator) on the concept of fasted training using AP pre-workout. This is where I prefer AP over P-Slin. Then I follow-up post workout with P-Slin.
Mulletsoldier said:
Anabolic Pump is often conceptualized as merely a supplement of glucose homeostasis. While that's true in part, its true identity is one of energy metabolism as a whole; specifically, modulating energy expenditure and transfer in both fat and muscle cells, via the modulation of energy storage and production mechanisms.

During a long bout of exercise (i.e., an hour long resistance training session) your body's energy homeostasis mechanisms need to take on a more oxidative (the B-oxidation of fatty acids) as opposed to glycolytic (GLUT4 translocation and glucose storage) role. This is due in part to the inability of the body to produce the fuel (glucose) for anabolic processes at the rates needed for anaerobic exercise. In response, your body has in place several mechanisms which prevent the accumulation and synthesis of triglycerides and lipids, and release them into the bloodstream to be oxidized.

These lipolytic processes actually contribute to the majority of energy transaction in a bout of anaerobic exercise - the oxidation of fatty acids and plasma triglycerides, primarily, provide the energy for resistance training.

The reason I mention all this is Anabolic Pump's fascinating ability to regulate one of the vanguards of oxidative and glycolytic energy consumption - AMPk. AMPk works as an essential gate-keeper of energy production, reacting to extracellular fluctuations of various downstream energy messengers (AMP:ATP ratio included). Its activation is responsible for various roles, including all of the above mentioned.

Using such a product in conjunction with fasted cardio simply utilizes energy which would have been stored anyway. The mere presence of AMPk ensures that the liberated fatty acids and triglycerides will be oxidized as it plays a primary role in not only lipolysis, but the inhibition of lipid, triglyceride, and cholesterol synthesis.

In terms of blood glucose, you should have circulating plasma levels which are enough to stave off hypoglycaemia, even with the use of Anabolic Pump. As carbohydrates have not been ingested, the presence of Insulin (the main inducer of hypoglycemia) is not necessarily present. Anabolic Pump works through Insulin-reactive, though not dependent, pathways of energy metabolism. The lipolytic role is also enough to provide ample energy.

Hope that helps!

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when using P-slin and ALA in concert.....what is the recommended dosage per X amount of carbs? for ALA usually I do 250mg per 30 grams carbs....so if you used P-slin while using ALA at such dosages, what is the ratio of P-slin bulk to carbs? or should they not be used together?
 
WARBIRDWS6 said:
when using P-slin and ALA in concert.....what is the recommended dosage per X amount of carbs? for ALA usually I do 250mg per 30 grams carbs....so if you used P-slin while using ALA at such dosages, what is the ratio of P-slin bulk to carbs? or should they not be used together?
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I would not recommend to stack the two. A 400mg serving of Bulk P-Slin can handle up to 100g-120g carbohydrates.
 
strategicmove said:
I would not recommend to stack the two. A 400mg serving of Bulk P-Slin can handle up to 100g-120g carbohydrates.
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OK, because I was using ALA with recompadrol (250mg ALA per 25-30 carbs and 1 cap recompadrol per 50-60 grams carbs).....good to know what you should use together with what, and what to avoid mixing. thanks.
 
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