What is metformin used for?

the Improvement in insulin sensitivity is a byproduct of its mechanism

technically it reduces gluconeogenesis

however most of it’s off label use (including my own) is for longevity reasons. Studies consistently seem to show a reduction in all cause mortality from metforim use.....
 
Whisky said:
the Improvement in insulin sensitivity is a byproduct of its mechanism

technically it reduces gluconeogenesis

however most of it’s off label use (including my own) is for longevity reasons. Studies consistently seem to show a reduction in all cause mortality from metforim use.....
Click to expand...

Do you use it all the time?
 
It inhibits muscle growth. Also depletes folate, vitamin B12, etc. Not something you'd want to take unless you are diabetic. Use natural alternatives like cinnamon, Alpha Lipoic Acid (R-ALA form), Berberine, etc. However, anytime you preferentially activate the AMPK pathway, muscle growth will be inhibited to some degree. Depends on if you are trying to maximize fat loss or muscle growth.
"Metformin activates the AMPK pathway through LKB1, eventually causing inhibition of the mTOR pathway and thus a reduction in protein synthesis and cellular proliferation. Metformin also appears to indirectly reduce Akt activation, through AMPK- mediated phosphorylation of IRS-1, causing inhibition of mTOR pathway."
 
Supposedly has some anti aging properties too but just go with Berberine. It has shown to be more effective than metformin without the crazy amount of GI distress
 
PhoenixGamer said:
It inhibits muscle growth. Also depletes folate, vitamin B12, etc. Not something you'd want to take unless you are diabetic. Use natural alternatives like cinnamon, Alpha Lipoic Acid (R-ALA form), Berberine, etc. However, anytime you preferentially activate the AMPK pathway, muscle growth will be inhibited to some degree. Depends on if you are trying to maximize fat loss or muscle growth.
"Metformin activates the AMPK pathway through LKB1, eventually causing inhibition of the mTOR pathway and thus a reduction in protein synthesis and cellular proliferation. Metformin also appears to indirectly reduce Akt activation, through AMPK- mediated phosphorylation of IRS-1, causing inhibition of mTOR pathway."
Click to expand...

it’s the inhibition of mtor that is key to longevity. Also the reason fasting is said to increase longevity.

it’s a balancing act. Periods of growth and periods of less growth
 
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