I had bloods done while taking IGF-2 and my SHBG was elevated and IGF-1 and free test was down. I get bloods often due to anti-aging endo I see, but I do not take test or hgh . . . yet, but will when my natural levels decline. 45 now and IGF-1 is generally in 290+ range and TTest around 590 to 600. My IGF-1 dropped to like 200 and my SHBG almost double after taking IGF-2. Could be other factors at play, could be just my body. I posted results on App Nut section back when bloods came back.