Personally I like using Nolva at the onset of any symptoms for it's affinity to bind directly in the breast tissue and an AI to control E to keep it from getting out of hand. I have had good results with Letro, but it crushes my libido and is hard on lipids. (not the most desireable thing if your already wreaking havoc on them with an oral) Formestane, although I believe it to be a weak AI compared to others, works really well for me at controlling E vs destroying while leaving my libido and lipids as they were. Arimidex I have never used but have heard great things from trusted sources ie. easy on libido but lipids will still be of concern. 6-OXO was not my friend, it may work well for others but gave me acne something fierce. I am currently experimenting with ATD off cycle to see how I respond to it before testing "on" but so far me likey. I believe once I narrow in on effective/tolerable dose ranges it will be quite effective on cycle as needed. Transdermal may be the way to go with ATD for the steady extended release over roughly 10-12 hrs. $.02