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Vitamin D3 Supplementation and Sides

I'll have to check out the B-Minus product. That sounds like it might be pretty good. Completely understand how you feel about spending money on products and not being able to use them. I've been having great luck with sabroxy lately. Hopefully that continues.

My current sleep product has 150 mg of niacin. So, hopefully that will be enough. If not, there's a couple vitamin and natural foods stores nearby that carry it. Also, the product is really meant as a mood/anti-anxiety supplement for daytime use. I just used it for sleep because of the tryptophan in it. So, I could always take it at the same time as the B9/B12 product to calm things down (if needed).
Well, you may want to take that methyl product in the morning since you already battle insomnia. On the flip side, you might be fine and not respond like I do at all. I know I'm in the minority.
What is sabroxy?
 
Well, you may want to take that methyl product in the morning since you already battle insomnia. On the flip side, you might be fine and not respond like I do at all. I know I'm in the minority.
What is sabroxy?
Yeah, I'll definitely be taking the methyl product in the morning since it's geared towards increasing Dopamine. The sleep product is for increasing Serotonin (also have a third product they make that's for increasing gaba)...which typically makes me tired, so I take it at night.

Sabroxy is a natural product which is standardized for Oroxylin-A (acts as a DRI).
 
Yeah, I'll definitely be taking the methyl product in the morning since it's geared towards increasing Dopamine. The sleep product is for increasing Serotonin (also have a third product they make that's for increasing gaba)...which typically makes me tired, so I take it at night.

Sabroxy is a natural product which is standardized for Oroxylin-A (acts as a DRI).
Gotcha. Let me know how it goes.
 
Yeah, I'll definitely be taking the methyl product in the morning since it's geared towards increasing Dopamine. The sleep product is for increasing Serotonin (also have a third product they make that's for increasing gaba)...which typically makes me tired, so I take it at night.

Sabroxy is a natural product which is standardized for Oroxylin-A (acts as a DRI).
Have you tried the methyl product yet?
 
told by my doc to take 10k of d before bed with k, started yesterday best sleep in along time didn’t even get up to go pee. Normally get up once per night will continue and see how it goes.
 
told by my doc to take 10k of d before bed with k, started yesterday best sleep in along time didn’t even get up to go pee. Normally get up once per night will continue and see how it goes.
Wow...before bed? I'm too scared to try that lol.
What was your level?
 
I feel like I sound like a rep, but for those with ANXIETY symptoms, look into trying Laxogenin. Maybe overhyped by the salesmen for gains, but for stress, I've found it works great!
I like transdermal or a blend with bioprene for better absorption.

Also +1 for Magnesium, CBD, and a supplement called TranquilX
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Sleep and anxiety issues are hard to pinpoint. I made progress with stress and sleep when I started addressing deficiency (magnesium) cortisol (Laxo) and Prolactin (Green tea / mucuna).

EDIT: Forgot another key to improving my sleep that you probably wont hear about much here: Limiting Electro Magnetic Frequency (EMF) exposure at night. Though I know now I am EM 'Sensitive', I think everyone could benefit from distancing or powering off cell phones and wifi emitters when trying to sleep.
 
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Have you tried the methyl product yet?
I tried it yesterday afternoon and after I woke up early this morning. I only took one capsule each time (so, about 0.3 mg of methylfolate and 1.3 mg of methylcobalin) and hated it. Very weird feeling...felt drowsy about an hour or so after taking it but also very anxious (essential tremor significantly worse). I tried the other product (with the niacin) this morning but that just made the drowsiness worse and lowered my mood more (I've tried high dose niacin by itself in the past and it has a very negative effect on my depression). I think I need to just try a b12 supplement itself and one that not a methylated form...
 
I tried it yesterday afternoon and after I woke up early this morning. I only took one capsule each time (so, about 0.3 mg of methylfolate and 1.3 mg of methylcobalin) and hated it. Very weird feeling...felt drowsy about an hour or so after taking it but also very anxious (essential tremor significantly worse). I tried the other product (with the niacin) this morning but that just made the drowsiness worse and lowered my mood more (I've tried high dose niacin by itself in the past and it has a very negative effect on my depression). I think I need to just try a b12 supplement itself and one that not a methylated form...
Look into that Seeking Health Minus One and get some extra hydroxycobalamin. That's what I'm getting ready to try...nervous to try that too, but I gotta do something. The methyls give me wayyyyy too much brain stimulation (likely too much dopamine due to COMT mutations). But, I've also had horrible experiences with other vitamins too. Frustrating. My wife can take whatever and marginally notice a difference. Jealous.
 
I tried it yesterday afternoon and after I woke up early this morning. I only took one capsule each time (so, about 0.3 mg of methylfolate and 1.3 mg of methylcobalin) and hated it. Very weird feeling...felt drowsy about an hour or so after taking it but also very anxious (essential tremor significantly worse). I tried the other product (with the niacin) this morning but that just made the drowsiness worse and lowered my mood more (I've tried high dose niacin by itself in the past and it has a very negative effect on my depression). I think I need to just try a b12 supplement itself and one that not a methylated form...
Did you get any muscle cramps or tightness?
 
Look into that Seeking Health Minus One and get some extra hydroxycobalamin. That's what I'm getting ready to try...nervous to try that too, but I gotta do something. The methyls give me wayyyyy too much brain stimulation (likely too much dopamine due to COMT mutations). But, I've also had horrible experiences with other vitamins too. Frustrating. My wife can take whatever and marginally notice a difference. Jealous.
I'll take a look at that one. Thanks. My brother did give me a multivitamin he wasn't taking (Garden of Life Mykind Organics Men's Multivitamin). It's around 100% for each of the vitamins. So, I'll probably try that next and see if I can handle a lower dose of everything.

My wife is the same way, she takes Numedica B Replete once or twice each day (along with a strong multivitamin) and barely notices anything. I mean, they're just vitamins, so I wouldn't expect to feel much. However, a b complex or multivitamin gets me way more stimulated than caffeine or other, stronger stimulants. I just don't get it...
 
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No cramps and the only tightness felt was kind of an internal tension. It's impact on my tremor was the worst though (even impacted my voice...which only happens when stimulated way too high).
Yeah, I don't understand it. I've went to the ER because of overstimulation from 1600mcg methylfolate and 1200mcg methyl b12. I didn't know what was happening at the time or what caused it, but it was as intense as recreational drugs without the euphoria, plus a side of extra anxiety. Horrible.

Interesting you say it effects your voice as I've noticed mine quivering at times when I don't even feel nervous. It's really bizarre. I thought it was due to my testosterone dosage change, but it might be due to this.
 
Same symptoms as I've had for about a decade...tired most of the time, insomnia, brain fog, nausea often, etc. I just asked him to test B12 on a whim this time (he wouldn't even test for vitamin d if I didn't ask each visit). The supplement I ordered has 1,000 mcg of methyfolate and 4,000 mcg of methylcobaline per 3 capsules (along with B-6, tyrosine, TMG and L-Phenylalanine ). I'm just going to start with 1 capsule each day. Hopefully that will put some pep in my step because caffeine just doesn't cut it anymore (and I'm well overdue for a break from caffeine).
When you tested for b12, we're you taking any in a multi at that time at all? And were you fasted?
 
Yeah, I don't understand it. I've went to the ER because of overstimulation from 1600mcg methylfolate and 1200mcg methyl b12. I didn't know what was happening at the time or what caused it, but it was as intense as recreational drugs without the euphoria, plus a side of extra anxiety. Horrible.

Interesting you say it effects your voice as I've noticed mine quivering at times when I don't even feel nervous. It's really bizarre. I thought it was due to my testosterone dosage change, but it might be due to this.
Sorry to hear you went through that. Yeah, your voice issue might be due to it. A quiver in the voice is a good way to describe it (also have trouble getting a word out...like it's on the tip of my tongue but just can't).
 
Sorry to hear you went through that. Yeah, your voice issue might be due to it. A quiver in the voice is a good way to describe it (also have trouble getting a word out...like it's on the tip of my tongue but just can't).
Yes, I've struggled with getting words out and getting tongue tied too. Frustrating.
 
No multivitamin at the time and I was fasted.
Have you had any difficulty swallowing too? Or electric shock vibrations in your legs or arms after exercise?

Also, been reading b12 deficiency and mthfr on reddit. I've stopped all multi as of today. Only took vitamin c, d, magnesium and fishoil this morning after a hellish couple days of overstimulation. I'll be resuming with only hydroxycobalamin at 250mcg to start to ensure I tolerate it, then bump to 500mcg, etc. I don't know how people go so long without being diagnosed. This is miserable.
 
Have you had any difficulty swallowing too? Or electric shock vibrations in your legs or arms after exercise?

Also, been reading b12 deficiency and mthfr on reddit. I've stopped all multi as of today. Only took vitamin c, d, magnesium and fishoil this morning after a hellish couple days of overstimulation. I'll be resuming with only hydroxycobalamin at 250mcg to start to ensure I tolerate it, then bump to 500mcg, etc. I don't know how people go so long without being diagnosed. This is miserable.
No, I haven't had either of those issues. However, my "exercise" over the last few years mostly consists of giving the kids blanket and piggyback rides around the house (which apparently 30+ years of working out didn't truly prepare me for)...
 
Same symptoms as I've had for about a decade...tired most of the time, insomnia, brain fog, nausea often, etc. I just asked him to test B12 on a whim this time (he wouldn't even test for vitamin d if I didn't ask each visit). The supplement I ordered has 1,000 mcg of methyfolate and 4,000 mcg of methylcobaline per 3 capsules (along with B-6, tyrosine, TMG and L-Phenylalanine ). I'm just going to start with 1 capsule each day. Hopefully that will put some pep in my step because caffeine just doesn't cut it anymore (and I'm well overdue for a break from caffeine).

This is a total shot in the dark, but have you ever been exposed to mold? I've been dealing with a number of health related issues myself over the last year or so, and the latest theory my doctor has proposed is the possibility that because of ongoing mold exposure I am suffering from CIRS (chronic inflammatory response syndrome). In genetically susceptible members of the population (estimated to be in the 25% range), they are unable to remove the toxins from their bodies after mold exposure and this sets of a cascade of worsening symptoms over time. It seems that only functional medicine doctors are typically aware of this condition and how to treat it.

The first link has a few questionnaires that you can go through to determine whether it's possible that you may be dealing with mold related illness.

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This is a total shot in the dark, but have you ever been exposed to mold? I've been dealing with a number of health related issues myself over the last year or so, and the latest theory my doctor has proposed is the possibility that because of ongoing mold exposure I am suffering from CIRS (chronic inflammatory response syndrome). In genetically susceptible members of the population (estimated to be in the 25% range), they are unable to remove the toxins from their bodies after mold exposure and this sets of a cascade of worsening symptoms over time. It seems that only functional medicine doctors are typically aware of this condition and how to treat it.

The first link has a few questionnaires that you can go through to determine whether it's possible that you may be dealing with mold related illness.

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I'm not aware of any exposure to mold. Thank you for the information and links. I'll have to take a look at those.
 
No, I haven't had either of those issues. However, my "exercise" over the last few years mostly consists of giving the kids blanket and piggyback rides around the house (which apparently 30+ years of working out didn't truly prepare me for)...
Have you started b12 supplements again yet? Im on day 2 of only a mix of adenocobalamin and hydroxocobalamin at a total dose of probably 100mcg so far. Even this feels like a bit too much, even though it shouldn't. I did find a very low dose multi on Amy Yasko's I might try too. It only has hydroxycobalamin as the b12; there is a tiny amount of methylfolate, but the rest is folinic acid.
 
Have you started b12 supplements again yet? Im on day 2 of only a mix of adenocobalamin and hydroxocobalamin at a total dose of probably 100mcg so far. Even this feels like a bit too much, even though it shouldn't. I did find a very low dose multi on Amy Yasko's I might try too. It only has hydroxycobalamin as the b12; there is a tiny amount of methylfolate, but the rest is folinic acid.
Not yet. Things haven't been going well lately. So, I've only been taking high dose bacopa to calm/sedate me. I plan on trying it again once things stabilize.
 
Not yet. Things haven't been going well lately. So, I've only been taking high dose bacopa to calm/sedate me. I plan on trying it again once things stabilize.
Sorry man. I get that. For me personally though, I'm kind of in a rush to fix this after reading about long term b12 deficiency consequences. And after finding out I'm +/+ for MTRR A66G mutation, I've likely been deficient in b12 for a decade or 2. I don't fully understand it, other than I'll need to supplement forever. On the plus side, my hematocrit and hemoglobin are still in decent places after my last blood donation...praise God. Was worried about that too.
 
I bought supplements from Invalid Link Removed. I have a great experience of it and I highly recommend you all at least visit store once and check their prices and quality!
 
I bought supplements from (link deleted). I have a great experience of it and I highly recommend you all at least visit store once and check their prices and quality!
Oooo I can't wait to click that link and have a great experience of it too!
🤖o_O
:ROFLMAO:
 
Sorry man. I get that. For me personally though, I'm kind of in a rush to fix this after reading about long term b12 deficiency consequences. And after finding out I'm +/+ for MTRR A66G mutation, I've likely been deficient in b12 for a decade or 2. I don't fully understand it, other than I'll need to supplement forever. On the plus side, my hematocrit and hemoglobin are still in decent places after my last blood donation...praise God. Was worried about that too.

good luck finding a decent B12 supplement. maybe there's something new out there, but afaik injectable is the only quick way to raise levels. I like AA's injectable b12
 
Sorry man. I get that. For me personally though, I'm kind of in a rush to fix this after reading about long term b12 deficiency consequences. And after finding out I'm +/+ for MTRR A66G mutation, I've likely been deficient in b12 for a decade or 2. I don't fully understand it, other than I'll need to supplement forever. On the plus side, my hematocrit and hemoglobin are still in decent places after my last blood donation...praise God. Was worried about that too.

good luck finding a decent B12 supplement. maybe there's something new out there, but afaik injectable is the only quick way to raise levels. I like AA's injectable b12
 
good luck finding a decent B12 supplement. maybe there's something new out there, but afaik injectable is the only quick way to raise levels. I like AA's injectable b12
Yeah, maybe I said that wrong. Injectable is not an option for me. I'd rather take the long and safer method to fix this. Id prefer to not risk hypokalemia or bizarre side effects from a massive dose absorbed from injection. As long as I'm making forward progress, I'm good. I'm still in shell shock from my experience with methylcobalamin and methylfolate last week. The overstimulation made me want to check into a hospital. Felt like everything bad from taking too much amphetamine without any euphoria. Today just used hydroxocobalamin at about 200mcg. So far ok.
 
Yeah, maybe I said that wrong. Injectable is not an option for me. I'd rather take the long and safer method to fix this. Id prefer to not risk hypokalemia or bizarre side effects from a massive dose absorbed from injection. As long as I'm making forward progress, I'm good. I'm still in shell shock from my experience with methylcobalamin and methylfolate last week. The overstimulation made me want to check into a hospital. Felt like everything bad from taking too much amphetamine without any euphoria. Today just used hydroxocobalamin at about 200mcg. So far ok.

you really might consider persuing natural vitamin sources in food. eat some liver or something. supplements seem to mess you up
 
Not yet. Things haven't been going well lately. So, I've only been taking high dose bacopa to calm/sedate me. I plan on trying it again once things stabilize.
How is this going? I'm living on lemon balm from Nootropics Depot basically, and just a quarter of their 10:1 extract is strong for me. It also helps with the muscle pain/tightness. Can't even workout anymore.
 
How is this going? I'm living on lemon balm from Nootropics Depot basically, and just a quarter of their 10:1 extract is strong for me. It also helps with the muscle pain/tightness. Can't even workout anymore.
It's going well. I'm taking the ND bacopa extract. Seems to work better than other extracts I've tried. Only issue is getting pretty tired in the afternoon. I may try halving the dose. Their new holy basil extract works well too.

With regard to niacin and methyl b9 and b12, in your experience what dose is typically required to offset the stimulation? My wife has the b complex shown below and I'm thinking about trying it again (maybe with some lithium orotate).

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It's going well. I'm taking the ND bacopa extract. Seems to work better than other extracts I've tried. Only issue is getting pretty tired in the afternoon. I may try halving the dose. Their new holy basil extract works well too.

With regard to niacin and methyl b9 and b12, in your experience what dose is typically required to offset the stimulation? My wife has the b complex shown below and I'm thinking about trying it again (maybe with some lithium orotate).

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lol that much methylcobalamin and I'd be in the ER.
Regarding niacin, 50mg turns off overstimulation pretty well. I've gone up to 100mg a couple times, and I think the most I've used in a day was 200mg (50, 50, 100). I have a multi by Thorne that has similar doses of niacin/niacinamide and pantothenic acid. I haven't tried it since the insomnia that I went through but I'm nervous about trying it again due to the newfound comt mutations I have. At max dose, 6 caps, it has 450mcg methylcobalamin and 1mg methylfolate. I used half that, 3 caps. I never really felt overstimulation from it either, and I wonder if it's because of the larger then typical dose of niacinamide as well as some niacin already in it, or that the amount of methylfolate was double the methylcobalamin. I will say though, there were times when I couldn't completely turn off the overstimulation and had to ride it out. It was still quite unpleasant. It was bad enough that I won't be using those products again.

I'm noticing a trend...b12 without enough folate and anxiety rips. But, if I eat plenty of folate or take enough, the anxiety goes away (eating enough wasn't possible with methylcobalamin though, only hydroxocobalamin). I haven't perfected this yet as it's a recent realization, but I'm wondering if I'm in a constant state of folate deficiency and that's what's causing the leftover symptoms I still have.
 
Yeah, what you said (about having to just ride out the over stimulation) is what has me leery of trying the b complex. However, I may just take half (or quarter) capsule and see how that goes.

Huh...I never thought about a connection between b9 and b12 with regard to anxiety. I'll have to watch for that too. I always thought I was having problems with folate. However, I recently tried a product called OmegaTau by ND. It has a pretty high dose of methylfolate in it (no b12) and I didn't have any anxiety from that product. Admittingly, maybe one of the other ingredients was offsetting it but was still surprised.
 
Yeah, what you said (about having to just ride out the over stimulation) is what has me leery of trying the b complex. However, I may just take half (or quarter) capsule and see how that goes.

Huh...I never thought about a connection between b9 and b12 with regard to anxiety. I'll have to watch for that too. I always thought I was having problems with folate. However, I recently tried a product called OmegaTau by ND. It has a pretty high dose of methylfolate in it (no b12) and I didn't have any anxiety from that product. Admittingly, maybe one of the other ingredients was offsetting it but was still surprised.
After reading quite a bit more and getting active in the b12 deficiency subreddit, the general consensus there is if we respond strongly to supplementation, then we that much more deficient. I'm not sure how much I buy that, because I had been taking a multi with methyl forms for a few years and didn't realize it was giving me inhuman energy until I switched to something else. I could be wrong, but I would think I would've adapted eventually.

I will say that even folinic acid gave me a strong reaction yesterday. Took 200mcg, half a cap, and within an hour I was freezing with a huge neurotransmitter rush...unsure which one, almost pleasant but too strong. So, I don't have it all figured yet. I'll try it again today at an even lower amount. 50mg niacin turned it off effectively though.

I'm going to look up that OmegaTau product. Interesting that it doesn't have any b12 in it.
 
After reading quite a bit more and getting active in the b12 deficiency subreddit, the general consensus there is if we respond strongly to supplementation, then we that much more deficient. I'm not sure how much I buy that, because I had been taking a multi with methyl forms for a few years and didn't realize it was giving me inhuman energy until I switched to something else. I could be wrong, but I would think I would've adapted eventually.

I will say that even folinic acid gave me a strong reaction yesterday. Took 200mcg, half a cap, and within an hour I was freezing with a huge neurotransmitter rush...unsure which one, almost pleasant but too strong. So, I don't have it all figured yet. I'll try it again today at an even lower amount. 50mg niacin turned it off effectively though.

I'm going to look up that OmegaTau product. Interesting that it doesn't have any b12 in it.

In case you're interested, I did come across this b complex (THIAVITE B-COMPLEX by Objective Nutrients) that looks pretty good. The only thing that might keep me from buying it is the cdp choline in it (supplemental choline tends to increase my depression a lot). I really like that it includes TTFD. I've been taking Lipothiamine and it helps a lot with calming me down (I tend to take it at night and it helps me sleep).

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In case you're interested, I did come across this b complex (THIAVITE B-COMPLEX by Objective Nutrients) that looks pretty good. The only thing that might keep me from buying it is the cdp choline in it (supplemental choline tends to increase my depression a lot). I really like that it includes TTFD. I've been taking Lipothiamine and it helps a lot with calming me down (I tend to take it at night and it helps me sleep).

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I'm just seeing this post! That b complex looks great; I just wish the doses were a little less potent. Have you tried it yet? I'm still just using 250mcg hydroxocobalamin and eating more eggs, but recently I'm starting to feel nausea and headache by the end of every day (but I wake up fine). Unsure what this is...
 
I know I'm late to this party, but there are people that v-b and v-d do not work orally for.

Especially v-d. My uncle was taking 20,000 iu per week and it did not change his numbers at all, then he got out on a 70,000iu injection every 2 weeks for a while and then 50,000iu 1x month and he's top range always now. Swears there's a noticeable difference in performance and overall wellness too
 
I know I'm late to this party, but there are people that v-b and v-d do not work orally for.

Especially v-d. My uncle was taking 20,000 iu per week and it did not change his numbers at all, then he got out on a 70,000iu injection every 2 weeks for a while and then 50,000iu 1x month and he's top range always now. Swears there's a noticeable difference in performance and overall wellness too
Edit: he was originally taking 20,000 IU per day, not per week
 
I'm just seeing this post! That b complex looks great; I just wish the doses were a little less potent. Have you tried it yet? I'm still just using 250mcg hydroxocobalamin and eating more eggs, but recently I'm starting to feel nausea and headache by the end of every day (but I wake up fine). Unsure what this is...
I used it for about a week. For once a b complex didn't increase my anxiety. However, what I feared might happen (increase in depression from the cdp choline), did happen and I stopped taking it. I really wish they hadn't included that because otherwise it likely would have been perfect for me.
 
I used it for about a week. For once a b complex didn't increase my anxiety. However, what I feared might happen (increase in depression from the cdp choline), did happen and I stopped taking it. I really wish they hadn't included that because otherwise it likely would have been perfect for me.
Are you using anything now for the b12 deficiency?
 
Are you using anything now for the b12 deficiency?
No, still just using bacopa during the day (and magnesium l-threonate before bed). Too many things going on right now at work and home. Can't afford lost time (or mood issues) from other b12/d3 supplements right now.
 
No, still just using bacopa during the day (and magnesium l-threonate before bed). Too many things going on right now at work and home. Can't afford lost time (or mood issues) from other b12/d3 supplements right now.
I know how you feel. I'm about to man up and use sublingual b12, but gotta sike myself up for a few days first lol.
 
In case you're interested, I did come across this b complex (THIAVITE B-COMPLEX by Objective Nutrients) that looks pretty good. The only thing that might keep me from buying it is the cdp choline in it (supplemental choline tends to increase my depression a lot). I really like that it includes TTFD. I've been taking Lipothiamine and it helps a lot with calming me down (I tend to take it at night and it helps me sleep).

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Recently found this thread again and looks like I've worked up to nearly the same doses of each B vitamin that are in this b complex. I just wish there was molybdenum and all in it too. Did this b complex make you tired though? Looks like this doses of b2 and niacin together might...
 
Recently found this thread again and looks like I've worked up to nearly the same doses of each B vitamin that are in this b complex. I just wish there was molybdenum and all in it too. Did this b complex make you tired though? Looks like this doses of b2 and niacin together might...

Yeah, it made me pretty tired. However, that could have been due to the cdp choline (which alone makes me very tired). I believe that company has a new b complex that doesn't include the cdp choline. However, I think the b9 and b12 forms are different too.
 
This is a total shot in the dark, but have you ever been exposed to mold? I've been dealing with a number of health related issues myself over the last year or so, and the latest theory my doctor has proposed is the possibility that because of ongoing mold exposure I am suffering from CIRS (chronic inflammatory response syndrome). In genetically susceptible members of the population (estimated to be in the 25% range), they are unable to remove the toxins from their bodies after mold exposure and this sets of a cascade of worsening symptoms over time. It seems that only functional medicine doctors are typically aware of this condition and how to treat it.

The first link has a few questionnaires that you can go through to determine whether it's possible that you may be dealing with mold related illness.

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What test did you do for mold? I'm now heading down this path as well.
 
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