this is an interesting thing from l rea , check it out :
"Winstrol (stanozolol) is a c17-alkylated non-aromatizing AAS utilized both orally and as an injectable preparation. Oddly enough is that the only commercially available injectable is a non-hydrophilic (does not dissolve in water) veterinarian preparation in sterile water. I say odd due to the fact that an oil preparation is notably more effective due to a prolonged active-life and the lymphatic percentage absorption factor. More bang for your buck so to speak. The oral has the distinct advantage of possessing a surprising degree of IGF-1 stimulation as it passes through the livers hepatic passages and as a result of cellular interaction in lean mass tissues. This has failed to be validated in most clinical research due to the low dosages (about 10mg/d) administered. Oddly enough reviews of blood work performed upon several notable athletes administering stanozolol in excess of 40mg/d showed that IGF-1 was elevated significantly. The injectable preparations appear to induce some increase in natural localized MGF (Mechano Growth Factor), PGF-2, IGF-1 and IGF-2 production "site specifically". In that lies the key to a more synergistic approach to utilization.
The full body circulation of liver produced IGF-1 is full body effectual. This means that the extra IGF-! from oral stanozolol administration has an effect on the entire musculature as does the AAS itself. Unfortunately within a period of about 2 weeks this effect decreases significantly due to an adaptive response in the liver that shuts down the extra growth goodies and a decrease in IGF-1 receptor site sensitivity results as well due to various other hormone actuated events (Action/Reaction Factors). Less IGF-1 production and less receptor sensitivity means less muscle growth and poor chemical synergy.
Site specific administration of an injectable preparation of stanozolol has full body effects due to AAS induced androgenic and anabolic activity but only significant "localized" MGF, PGF-2, IGF-1 and IGF-2. MGF increases IGF-1 receptor sensitivity, PGF-2 increases androgen receptor count and sensitivity, and the localized IGF-1 production acts synergistically with the AAS. Oh, did I mention that the IGF-2 initiates an increase in vascular tissue growth for better nutrient supply?
Day 1-10 & 21-30 25-50mg 2xd (orally)
Day 11-20 & 31-40 50-75mg 2xd (site specifically) "