Ursolic Acid

This might answer that.

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as noted ... the study did have some limitations but all in all this has some insight that is very helpful to you finding the answer. I think too there has to be a more studies on the subject to get more info. When I used it mega dosing among two other testers I trust, we all 3 lost a lot of body fat, and 2 of us had a strong rebound of fat when we quit. so there is some things to look into in that regard (dosing size or timing as well as type of delivery) imo.
 
xR1pp3Rx said:
as noted ... the study did have some limitations but all in all this has some insight that is very helpful to you finding the answer. I think too there has to be a more studies on the subject to get more info. When I used it mega dosing among two other testers I trust, we all 3 lost a lot of body fat, and 2 of us had a strong rebound of fat when we quit. so there is some things to look into in that regard (dosing size or timing as well as type of delivery) imo.
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That’s disappointing. Would there be a rebound regardless of diet?

if you dramatically decreased calories after cycling it?

just how much you as a megadose?
 
I cant answer that, as I never tried it both ways, meaning, I mega dosed it that 1 time and don't recall continuing a diet. I like food so I tend to go up and down in weight as it suits my needs. I get lean in the summer and sloth it up in the winter. Diet and then bulk.. I'm all over the map.

I think if you use this as a diet aid; as in a fat loss tool, you may want to (or not) use it on the front end of a diet. finish with a GDA and stimulants/fat burners. [ purely based on personal exp.]

I ate a lot more than that study.. 1g or more per day seems to ring a bell. this would have been at least 10 yrs ago..



I think the the topical form Apex sells is where its at though. I have been using it with no working out or diet, and see changes in the mirror. that started about 1-2 weeks after i started at 1 ml per day applied to my shoulders 5 days on 2 days off.
 
In regards to cortisol, UA may help protect the brain from damage caused by high cortisol:

"The cytoprotective potential of UA against corticosterone-induced cytotoxicity and its ability to modulate intracellular signaling pathways involved in cell proliferation and survival suggest that UA may be a relevant strategy to manage stress-related disorders such as MDD."

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This is not about cortisol specifically but I thought it was interesting and in the spirit of the OP inquiry:

Ursolic acid is a pentacyclic triterpenoid found in several plants. Despite its initial use as a pharmacologically inactive emulsifier in pharmaceutical, cosmetic and food industries, several biological activities have been reported for this compound so far, including anti-tumoural, anti-diabetic, cardioprotective and hepatoprotective properties. The biological effects of ursolic acid have been evaluated in vitro, in different cell types and against several toxic insults (i.e. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, amyloid-β peptides, kainic acid and others); in animal models of brain-related disorders (Alzheimer disease, Parkinson disease, depression, traumatic brain injury) and ageing; and in clinical studies with cancer patients and for muscle atrophy. Most of the protective effects of ursolic acid are related to its ability to prevent oxidative damage and excessive inflammation, common mechanisms associated with multiple brain disorders. Additionally, ursolic acid is capable of modulating the monoaminergic system, an effect that might be involved in its ability to prevent mood and cognitive dysfunctions associated with neurodegenerative and psychiatric conditions. This review presents and discusses the available evidence of the possible beneficial effects of ursolic acid for the management of neurodegenerative and psychiatric disorders. We also discuss the chemical features, major sources and potential limitations of the use of ursolic acid as a pharmacological treatment for brain-related diseases.

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In regards to estrogen, UA probably won't lower your E2 levels on bloodwork but it may serve as an anti-estrogen at certain receptor sites:

"Furthermore, both mRNA and protein levels of ERα were reduced by treatment with UA or BA, suggesting that UA and BA inhibit estrogen signaling by suppressing the expression of ERα. Interestingly, both compounds enhanced Invalid Link Removed promoter activity. Collectively, these findings demonstrate that UA and BA are responsible for the antiestrogenic effects of P. vulgaris and suggest their potential use as therapeutic agents against estrogen-dependent tumors."

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I'm curious to hear anyone's opinions on the differences as to the different types of Ursolic Acid available.
 
I've always liked URA. I have 6 bottles of Ursa Major waiting for a nice run based off reviews on here. Only ever used oral at higher than suggested doses
 
I think you have to take alot of it to see results. I remember with the old e-pharm product people were taking 18 or more capsules a day.
 
semtex said:
I think you have to take a lot of it to see results. I remember with the old e-pharm product people were taking 18 or more capsules a day.
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this is why APEX does the sodium ursolate in a topical. the extremely poor absorption ursolic acid would have you eating boat loads to get the desired effects
 
I have tried UR spray at 50 sprays a day didn't see anything, I heard it's better at 100 sprays a day. And I saw some ok results with the old hydra head six at double the dose. I avoid transdermals now because I have little kids. But I am going to try the new myosynergy when it comes out.
 
xR1pp3Rx said:
this is why APEX does the sodium ursolate in a topical. the extremely poor absorption ursolic acid would have you eating boat loads to get the desired effects
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I know that the oral absorption of Ursolic Acid is poor.

I was wondering if you happened to know why some brands choose Sodium Ursolate instead of regular Ursolic Acid for topical purposes. Just a curiosity.
 
sns8778 said:
I know that the oral absorption of Ursolic Acid is poor.

I was wondering if you happened to know why some brands choose Sodium Ursolate instead of regular Ursolic Acid for topical purposes. Just a curiosity.
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Is there another brand with a Na-UA topical?

UA free acid is horribly insoluble in most carriers.
 
nostrum420 said:
Is there another brand with a Na-UA topical?

UA free acid is horribly insoluble in most carriers.
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Prototype uses the Arginine Ursolic Acetate.
Ursa Major uses Sodium Ursolate.
And I've seen some state Ursolic Acid and not specify.

So I was curious why Sodium Ursolate was chosen. I've seen in other places, and it may have been discussed here and I may have missed it, whether or not Ursolic Acid from Rosemary was a good candidate for a topical. From what I read somewhere else, it wasn't if it was a 25% or below but it was if it was a 50% or above.

Keep in mind, I'm not claiming it to be true either way. That's why I'm asking bc its something I had been curious about and had just never looked into but this thread made me think about it.
 
sns8778 said:
Prototype uses the Arginine Ursolic Acetate.
Ursa Major uses Sodium Ursolate.
And I've seen some state Ursolic Acid and not specify.

So I was curious why Sodium Ursolate was chosen. I've seen in other places, and it may have been discussed here and I may have missed it, whether or not Ursolic Acid from Rosemary was a good candidate for a topical. From what I read somewhere else, it wasn't if it was a 25% or below but it was if it was a 50% or above.

Keep in mind, I'm not claiming it to be true either way. That's why I'm asking bc its something I had been curious about and had just never looked into but this thread made me think about it.
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We start with a 98% extract and make the salt in-house. Lower quality extracts will generally result in crashing. Pat had trouble with his sprayers clogging up at one point, early on when the quality of the starting material he was able to source slipped even a little. It's definitely not the easiest stuff to work with. I've got to imagine if it just says Ursolic Acid then it's the free acid form. I'm pretty sure Pat and I are the only ones who have developed salt derivatives.
 
nostrum420 said:
We start with a 98% extract and make the salt in-house. Lower quality extracts will generally result in crashing. Pat had trouble with his sprayers clogging up at one point, early on when the quality of the starting material he was able to source slipped even a little. It's definitely not the easiest stuff to work with. I've got to imagine if it just says Ursolic Acid then it's the free acid form. I'm pretty sure Pat and I are the only ones who have developed salt derivatives.
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What do you mean by crashing?

I'm going to send you a pm as well to continue the discussion that way. I had some questions but don't want to confuse anyone just reading about the sources and forms of the ingredient.
 
sns8778 said:
What do you mean by crashing?

I'm going to send you a pm as well to continue the discussion that way. I had some questions but don't want to confuse anyone just reading about the sources and forms of the ingredient.
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I think we would all appreciate learning about these things, keep the discussion going
 
ironkill said:
I think we would all appreciate learning about these things, keep the discussion going
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Crashing refers to the product "falling" out of suspension. The product, in this case Ursa Major, becomes too cold or for other reasons, its separates from the carrier. The carrier being the liquid in which the sodium ursolate is dissolved into. Typically this can be remedied by placing the bottle/s in boiling water for a few mins. I do not recommend putting any topical into a microwave!! dont do that.
 
xR1pp3Rx said:
Crashing refers to the product "falling" out of suspension. The product, in this case Ursa Major, becomes too cold or for other reasons, its separates from the carrier. The carrier being the liquid in which the sodium ursolate is dissolved into. Typically this can be remedied by placing the bottle/s in boiling water for a few mins. I do not recommend putting any topical into a microwave!! dont do that.
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Thanks. That's what I thought he meant but I'd never heard it referred to that way. I had always just heard it referred to as separating or settling.

I remember back in the old days, a few people tried putting some topicals into microwaves. Made for some funny stories, but yeah, definitely shouldn't do that.
 
sns8778 said:
Thanks. That's what I thought he meant but I'd never heard it referred to that way. I had always just heard it referred to as separating or settling.

I remember back in the old days, a few people tried putting some topicals into microwaves. Made for some funny stories, but yeah, definitely shouldn't do that.
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Yikes.
 
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