GreenMachineX
Well-known member
So I've been looking at Hydrahead 6 to go with my cut this year and hold as much muscle as possible while I can't do any presses during my impingement physical therapy. But, regarding ursolic Acid, check out this info on examine:
"10.1. Angiogenesis
Ursolic acid (as well as related compounds maslinic acid and oleanolic acid[59]) is known as an angiogenesis inhibitor, preventing the formation of new blood vessels from larger ones. In blood vessel cells, ursolic acid seems to act via inhibiting the PI3K-Akt pathway and Nitric Oxide induction, which suppresses cellular changes preceding angiogenesis.[59][60] These results have been seen in vivo with nontoxic dosages of ursolic acid, and ursolic acid also inhibits expression of MMP2 and MMP9 (intermediates required for the final stages of angiogenesis into new tissue)[61]
This inhibition of vascularization is currently under investigation for its anti-cancer therapeutic potential, as new tumor cells require blood flow and need angiogenesis to occur for them to survive.[62] The previous study that tested rats with ursolic acid noted that the experimental group having ursolic acid at 4.25mcg/kg (50umol/kg) for 5 days had 42.03% as much vascularization in melanoma tumors as control (untreated)."
Isn't vascularization in building muscle a good thing? Is this only in regard to tumor cells? How would we know? And inhibiting nitric oxide induction doesn't sound good either. Any thoughts?
"10.1. Angiogenesis
Ursolic acid (as well as related compounds maslinic acid and oleanolic acid[59]) is known as an angiogenesis inhibitor, preventing the formation of new blood vessels from larger ones. In blood vessel cells, ursolic acid seems to act via inhibiting the PI3K-Akt pathway and Nitric Oxide induction, which suppresses cellular changes preceding angiogenesis.[59][60] These results have been seen in vivo with nontoxic dosages of ursolic acid, and ursolic acid also inhibits expression of MMP2 and MMP9 (intermediates required for the final stages of angiogenesis into new tissue)[61]
This inhibition of vascularization is currently under investigation for its anti-cancer therapeutic potential, as new tumor cells require blood flow and need angiogenesis to occur for them to survive.[62] The previous study that tested rats with ursolic acid noted that the experimental group having ursolic acid at 4.25mcg/kg (50umol/kg) for 5 days had 42.03% as much vascularization in melanoma tumors as control (untreated)."
Isn't vascularization in building muscle a good thing? Is this only in regard to tumor cells? How would we know? And inhibiting nitric oxide induction doesn't sound good either. Any thoughts?
