When I ran 11-ketotestosterone at 160 mg a day transdermal for 6 weeks no serm was needed, verified with bloodwork. Currently I'm running Epiandro at about 300mg TD + 600mg oral, Androsterone 250mg TD and Dermacrine 3 pumps a day. Been on 4 weeks and hopefully getting bloodwork in 1 - 2 weeks to see how it's affecting my hormones. As of now balls seem normal, no subjective signs of suppression, libido and morning wood are consistent and strong. Bloodwork is the only way to really know if you need a SERM though.