TRT Blood levels vs. natural levels question

[Justlooking5]

If you are natural, in theory your test levels are highest in the a.m. and then dip during the day, and are further affected by meals, poor sleep, training stress, body rhythms, etc.

So let's say a natural person pre-TRT had a.m. test levels at 350ng/dl after a good night's sleep. According to a few online references, test levels decline about 25-30% during the day.

So the guy has a.m. test levels of 350ng/dl, but p.m. test levels of 245 ng/dl

However (and this is my question), if the guy is on TRT, and let's say has test levels of 1,000 ng/dl during his trough, does that mean that he essentially has constant blood levels of at least 1,000 ng/dl at all times, day or night, and independent of meals, sleep levels, etc.?

Because that would mean that the guy in question now has test levels that are a minimum of 4-5x higher than his natty levels for a significant portion of the day. (i.e., 1,000 ng/dl vs. 245 ng/dl in the evenings).

That would be a pretty significant difference and maybe accounts for part of the steady (though not overwhelming) gains I've seen people report while on TRT.

 

[Nac]

If I understand your question...

The guy injecting, his levels over time (pin--rise--peak--decline--trough---pin---rise--etc) depend entirely on when he pins relative to previous pins, the ester, and his body's metabolism of the compound. So, there are still peaks/dips/troughs/rises.

The trt guy who has a 1000 trough, wont have a steady level of 1000. Depending on his pinning protocol (and ester, and metabolism of the drug), he will still have varying levels over time. But, its highly likely this variation (the numbers) will be much more consistent compared to a natty guy.

 

[Nac]

This might give you a general idea of the pattern (each trough is the point of inj):

Multi dose pharmacokinetics of test-e 250mg

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[Justlooking5]

Thanks. Actually that chart kind of suggests what I'm saying, I think. If you look at the "1 week" graph, it shows (other than a brief dip trough in the beginning) a peak of near 80 nm/l (supraphysiological), and a minimum of around 40 nm/l (about 1150 ng/dl). The levels swing from 40 to 80, but are ALWAYS above 40 ... no dips below the minimum level no matter time of day, food intake, sleep etc.

In other words 250mg/week gets you to a 1150 ng/dl or higher (up to about 2,000), all the time.

Compare to the guy at 350ng/dl in the morning dipping to 250 in the evening... very large difference. In the evening, the guy on 250mg test E has between 4-8x higher total testosterone levels than the moderately hypogonadal natural guy.

 

[Nac]

Yeah. A trough is a trough, by definition its the lowest point.

When, exactly, the trough occurs depends on multiple factors. But the natty guy is hostage to natural rhythms...the trt guy is in control of his pin-times. Natty guy, morning-evening....trt guy, pin-to-pin. So for the latter, morning-evening is irrelevant.