I take 2 pills a day. one at 6am with my breakfast, one about twelve hours later. i have not went up to 3 pills a day because, my god, if i'm losing 6 lbs a week, what else would this do? i also am concerned about losing muscle, and i think 3 a day might get me to a point where muscle is being eaten too fast.
long story short, 2 pills a day, about 12 hours apart. i think the half-life is about 6 hours, so you could take them 6-8 hours apart. for me, i'm guessing the half-life is a little longer, say 8 hours, so at the minimum, i take them 8 hours apart.