The tren PS (estra-4,9) does aggrevate gyno pretty bad. I know this from personal experience and by word of mouth. We're having a lot of people come back to stores that carry our estra-4,9 product (this is not a plug) with a "deer in the headlights" look on their face saying their nipples got puffy. They should have paid more attention to the label. :/
If you do choose to take this PS, keep the proper inhibitors on hand. Any experienced BB'er will tell you that its better to be safe than sorry.