My guess is that that is big leap, but good question regardless. I don't really know.
If it cellular necrosis were occuring, it might explain the renal issues related to tren.
I still doubt it. I think tren's fat burning abilities have more to do with it incredibly strong AR binding. I've also heard it will bind to, and temporarily disfigure the receptors of cortisol, which is why tren is so anti-catabolic. It literally renders cortisol useless.