vladmirgc
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So I was reading this medical case study about a 14-year old boy who developed symptoms of aspirin poisoning following masturbation by using pain-relief cream. It really caught my interest in the context of transdermal supplements.
Apparently there is a big difference in bioavailability depending on the site of administration. The paper "Regional variation in percutaneous penetration of 14C cortisol in man" (https://cir.nii.ac.jp/crid/1571698599654013696) illustrates it quite well. For example, below we have the absorption rate of different areas of the body
Given the scrotum is heavily vascularized, it has a greater absorption effect.
My goal is not to start applying supplements directly to my scrotum, because I think it may be dangerous. But it makes me wonder how supplement companies come up with their recommendations. Let us take for example Apex Alchemy. In their products they mention that ideal application areas include chest, clavicle, shoulders and upper arms. Why is that though? Couldn't we use a smaller dose and apply to an area with a higher absorption rate? The areas recommended do not seem particularly special.
Has anyone noticed any difference by optimizing application site?
Apparently there is a big difference in bioavailability depending on the site of administration. The paper "Regional variation in percutaneous penetration of 14C cortisol in man" (https://cir.nii.ac.jp/crid/1571698599654013696) illustrates it quite well. For example, below we have the absorption rate of different areas of the body
Given the scrotum is heavily vascularized, it has a greater absorption effect.
My goal is not to start applying supplements directly to my scrotum, because I think it may be dangerous. But it makes me wonder how supplement companies come up with their recommendations. Let us take for example Apex Alchemy. In their products they mention that ideal application areas include chest, clavicle, shoulders and upper arms. Why is that though? Couldn't we use a smaller dose and apply to an area with a higher absorption rate? The areas recommended do not seem particularly special.
Has anyone noticed any difference by optimizing application site?