Transdermal Methyls

motiv8er

motiv8er

Well-known member
Out of curiosity, has anyone gotten their liver values after a cycle of a methylated hormone in a transdermal carrier? If so, please direct me to that thread. I did a td superdrol cycle in March, felt great, few sides, and it felt way less harsh than my experience with orally dosed superdrol. But, that’s my highly unscientific description. Thanks!
 
motiv8er said:
Out of curiosity, has anyone gotten their liver values after a cycle of a methylated hormone in a transdermal carrier? If so, please direct me to that thread. I did a td superdrol cycle in March, felt great, few sides, and it felt way less harsh than my experience with orally dosed superdrol. But, that’s my highly unscientific description. Thanks!
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No labs but I do agree in terms of “feel” less harsh. Interested to see if anyone has labs
 
Avoiding the first pass on the liver could be a game changer for SD! Would be very interested to see a comparison!

Did you need a higher dose, or did you feel like it measured up mg for mg to oral administration?
 
motiv8er said:
Out of curiosity, has anyone gotten their liver values after a cycle of a methylated hormone in a transdermal carrier? If so, please direct me to that thread. I did a td superdrol cycle in March, felt great, few sides, and it felt way less harsh than my experience with orally dosed superdrol. But, that’s my highly unscientific description. Thanks!
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I have some oral SD on hand for my next cycle. We're probably about to discontinue our SD completely so I can probably get a few vials and compare labs on both. I'll bookmark the thread and hopefully remember 🙂

MadStax said:
Avoiding the first pass on the liver could be a game changer for SD! Would be very interested to see a comparison!

Did you need a higher dose, or did you feel like it measured up mg for mg to oral administration?
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The idea of avoiding the first pass makes some sense on paper, but also confuses me in practice . The first pass significantly reduces how much of the drug makes it into the blood. However, every anecdotal report I've read indicates that oral SD hits a LOT harder than TD. While oral offers additional release of igf, I doubt it's enough to really be considered a major contributing factor. Too bad it's scheduled and real lab research is not likely to continue ever again. 😞
 
TheVenom said:
I have some oral SD on hand for my next cycle. We're probably about to discontinue our SD completely so I can probably get a few vials and compare labs on both. I'll bookmark the thread and hopefully remember 🙂



The idea of avoiding the first pass makes some sense on paper, but also confuses me in practice . The first pass significantly reduces how much of the drug makes it into the blood. However, every anecdotal report I've read indicates that oral SD hits a LOT harder than TD. While oral offers additional release of igf, I doubt it's enough to really be considered a major contributing factor. Too bad it's scheduled and real lab research is not likely to continue ever again. 😞
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Looking forward to you remembering! 😜

This was my concern, which is why I asked if it felt like it was working as well mg for mg. My guess is that it's not, as most drugs don't.
 
MadStax said:
Looking forward to you remembering! 😜

This was my concern, which is why I asked if it felt like it was working as well mg for mg. My guess is that it's not, as most drugs don't.
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Yeah, TD drol is good in its own right, but not when you compare it to its own oral form. So there's nothing necessarily WRONG with it, it's better for your wallet and results to just use something else imo.
 
MadStax said:
Looking forward to you remembering! 😜

This was my concern, which is why I asked if it felt like it was working as well mg for mg. My guess is that it's not, as most drugs don't.
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Many drugs are much more effective via TD route.

Methyls ... I haven't seen or heard much reliable positive feedback on that.
 
TheVenom said:
I have some oral SD on hand for my next cycle. We're probably about to discontinue our SD completely so I can probably get a few vials and compare labs on both. I'll bookmark the thread and hopefully remember 🙂



The idea of avoiding the first pass makes some sense on paper, but also confuses me in practice . The first pass significantly reduces how much of the drug makes it into the blood. However, every anecdotal report I've read indicates that oral SD hits a LOT harder than TD. While oral offers additional release of igf, I doubt it's enough to really be considered a major contributing factor. Too bad it's scheduled and real lab research is not likely to continue ever again. 😞
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You have to factor in the fact that no where near 100% of a TD is getting absorbed in the first place. If there was a way to adjust the dosage of the TD vs the oral you could make a better comparison.
 
BCseacow83 said:
You have to factor in the fact that no where near 100% of a TD is getting absorbed in the first place. If there was a way to adjust the dosage of the TD vs the oral you could make a better comparison.
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Keep in mind that the bioavailability of ingested drugs can be quite low as well. Serum levels would need to be tested in both cases to get an idea of how much is delivered and over what period of time.
 
TheVenom said:
The idea of avoiding the first pass makes some sense on paper, but also confuses me in practice . The first pass significantly reduces how much of the drug makes it into the blood. However, every anecdotal report I've read indicates that oral SD hits a LOT harder than TD. While oral offers additional release of igf, I doubt it's enough to really be considered a major contributing factor. Too bad it's scheduled and real lab research is not likely to continue ever again. 😞
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No, skipping first pass metabolism gets it straight into the blood stream, where it circulates through the heart, and then goes to the liver. So with a TD, you're skipping that first pass metabolism and getting the drug directly in your blood immediately.
 
StarScream66 said:
No, skipping first pass metabolism gets it straight into the blood stream, where it circulates through the heart, and then goes to the liver. So with a TD, you're skipping that first pass metabolism and getting the drug directly in your blood immediately.
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Im not sure what you're disagreeing with?? I didn't say anything against your reply. Though I will say the "directly into the blood stream immediately" part isn't quite on the money
 
TheVenom said:
Im not sure what you're disagreeing with?? I didn't say anything against your reply. Though I will say the "directly into the blood stream immediately" part isn't quite on the money
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You said the idea of first pass metabolism confuses you, so I was trying to explain it to you. I didn't mean any offense. As far as directly in the bloodstream, sure it has to pass through t he dermis and all that, but it hits the blood stream first none-the-less and thus skips that first pass metabolism.
 
I've only done blood work for TD non methyls Dienolone and with one dose of TUDCA my AST ALT weren't even elevated. All were in normal range.

Perhaps on my next cycle I'll do a TD Methyl and do blood work.

With that said, my opinion is that just because it bypasses first pass doesn't mean the metabolites of the compound will not eventually raise liver enzymes. Is your TD from B....labs?
 
The superdrol I used was. Real happy with it
 
A methylated oral has a much higher bioavailability and more will be absorbed in comparison to a TD. It's methylated for the main reason to prevent it from degradation and orally active. By throwing it on a TD form you might as well go with unmethylated and dose 10x the amount since only about 5-10% will be absorbed anyways. Transdermal absorption rate for all steroids will be very similar to transdermal testosterone which is very well studied. Almost all steroids will be similar to testosterone in structure and molecular weight unless you keep adding long esters.
 
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