Thread: Anti Inflammatory Benefits of b-Androstenetriol (b-AET)

delsolrob

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Iconic Formulations Topical Androstenetriol - Neuro AET
Androstene-3 beta-7 beta-17 beta-triol (AET)
represents a key naturally occurring 7-hydroxy dehydroepiandrosterone (DHEA) metabolite. Produced from the adrenal gland, DHEA and its sulfate are the major circulating adrenal steroids in humans. Serum levels peak in young adults, but then steadily decline with age, falling over 80% by age 70. DHEA serves as a precursor of male and female sex hormones. (1, 3, 5, 6)

DHEA demonstrates a plethora of anti-aging properties in rodents, including anti-inflammatory, anti-obesity, anti-diabetic, immune enhancing activities, and opposes certain activities of endogenous glucocorticoids (GC). As the literature grew, DHEA became widely used as an anti-aging, anti-stress dietary supplement. Despite these well-documented activities in animal models, DHEA supplementation in humans has yielded inconclusive results and the value of DHEA replacement in humans is controversial. Such widely different outcomes in rodents and humans have been referred to as ‘the DHEA conundrum’. Moreover, the potential therapeutic use of DHEA is limited by its side effects due to its conversion to sex hormones.

One possibility to explain these discrepancies is that a metabolite(s) of DHEA, rather than DHEA itself, may be necessary for its full action in human physiology. DHEA undergoes extensive conversion and derivatization to multiple products by phase 1 reactions involving the cytochrome P450 system, and studies have shown that these phase 1 products can be more potent than parental DHEA. Phase 1 reactions frequently decline in elderly subjects, and since such subjects have been the major participants in human DHEA treatment studies, it is possible that biologically active metabolites of DHEA were not produced in adequate amounts in previous human studies. It is also possible that qualitative changes in DHEA metabolism between rodents and humans will account for these differences.

DHEA oxidation via the action of the enzyme CYP7B leads to the 7-hydroxy derivatives of C-19 steroids, which are collectively present in low nanomolar concentrations in human circulation and are not readily metabolized to potent androgens or estrogens. Many of the functions initially attributed to DHEA from observations in rodents are now thought to be properties of these oxygenated metabolites, particularly AET.

Molecular Structure of Androstenetriol

AET possesses some of the anti-inflammatory and GC-opposing activities that have been attributed to DHEA, but with greater apparent potency. Studies with AET demonstrate it markedly up regulates host immune response, prevents immune suppression, modulates inflammation and improves survival after lethal infections by pathogens and lethal radiation. (1, 3, 5, 6)

AET has been shown to be protective against traumatic shock. Traumatic shock activates the hypothalamic-pituitary-adrenal axis (HPA) to mediate a cascade of defensive mechanisms that often include overwhelming inflammatory response and immunosuppression, which may lead to multiple organ failure. In a relevant traumatic hemorrhagic shock rodent model that applies to both combat and civilian sectors, AET provided a significant protective effect and improved survival. In a murine thermal injury model that includes glucocorticoid-induced osteopenia, AET significantly preserved bone mineral content, restored whole body bone mineral content and bone growth, suggesting reversal of GC-mediated adverse effects.

Since AET is a naturally occurring compound there is no patent protection leaving the door wide open for AET analogue research. Harbor BioSciences, Inc. –http://www.harborbiosciences.com/ (Public, OTC:HRBR –OTC:HRBR - Google Search ) is exploring a synthetic derivative of AET for the treatment of diseases with underlying chronic inflammation. HRBR has developed 17alpha-Ethynyl-5-androsten-3beta, 7beta, 17beta-triol (HE3286), a synthetic derivative AET. (1, 2, 4, 7)

Within the past two years, animal model studies of HE3286 successfully demonstrate the treatment of lung inflammation without immune suppression, the reduction of established disease of rheumatoid arthritis, and both glucose-lowering and cholesterol-lowering effects. Harbor BioSciences most ambitious project to date is their recently released data regarding that plasma levels of AET positively correlate with BMI in healthy men and women.(1) These observations suggest a compensatory role for AET in preventing the development of metabolic syndrome and obesity. The AET structural core may provide the basis for novel pharmaceuticals to treat this disease, HE3286. Stay tuned.



1. Auci DL, Ahlem CN, Kennedy MR, Page TM, Reading CL, Frincke JM. A Potential Role for 5-Androstene-3[beta],7[beta],17[beta]-triol in Obesity and Metabolic Syndrome. Obesity. Academic Journals formerly published by NPG



2. Conrad D, Wang A, Pieters R, et al. HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression. Journal of Inflammation 2010;7(1):52. HE3286, an oral synthetic steroid, treats lung inflammation in mice without immune suppression | Journal of Inflammation | Full Text



3. Loria RM. Antiglucocorticoid function of androstenetriol. Psychoneuroendocrinology 1997;22 Suppl 1:S103-8.



4. Lu M, Patsouris D, Li P, et al. A new antidiabetic compound attenuates inflammation and insulin resistance in Zucker diabetic fatty rats. American Journal of Physiology – Endocrinology And Metabolism 2010;298(5):E1036-E48. http://ajpendo.physiology.org/content/298/5/E1036.full



5. Malik AK, Khaldoyanidi S, Auci DL, et al. 5-androstene-3?,7?,17?-triol (?-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis. PLoS ONE;5(10):e13566. 5-Androstene-3β,7β,17β-triol (β-AET) Slows Thermal Injury Induced Osteopenia in Mice: Relation to Aging and Osteoporosis



6. Marcu AC, Paccione KE, Barbee RW, et al. Androstenetriol Immunomodulation Improves Survival in a Severe Trauma Hemorrhage Shock Model. The Journal of Trauma 2007;63(3):662-9.



7. Offner H, Firestein GS, Boyle DL, et al. An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis. Journal of Pharmacology and Experimental Therapeutics 2009;329(3):1100-9. An Orally Bioavailable Synthetic Analog of an Active Dehydroepiandrosterone Metabolite Reduces Established Disease in Rodent Models of Rheumatoid Arthritis | Journal of Pharmacology and Experimental Therapeutics



8. Stiles AR, McDonald JG, Bauman DR, Russell DW. CYP7B1: One Cytochrome P450, Two Human Genetic Diseases, and Multiple Physiological Functions. Journal of Biological Chemistry 2009;284(42):28485-9.

Source: Anti-inflammatory Benefits of Androstenetriol (b-AET) - iconicformulations
 
thebigt

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INVICTUS-FOR THE WIN!!!
 
delsolrob

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Also, Iconic Formulations is now offering Neuro AET as part of the Neuro Series of products.

One of the updates for Neuro AET is the use of clary sage essential oils to offer synergy with the AET.

Clary sage has been shown to offer benefits for stress reduction/cortisol reduction and can also act as an antidepressant. Additionally, clary sage is also great for both men and women.
 
Ricky10

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Great read! So does Neuro AET have less b-AET than Invictus?

If clary sage (salvia) is synergistic with b-AET for cortisol control/stress reduction, is Neoro AET possibly better than Invictus for fat loss?
 
delsolrob

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Great read! So does Neuro AET have less b-AET than Invictus?

If clary sage (salvia) is synergistic with b-AET for cortisol control/stress reduction, is Neoro AET possibly better than Invictus for fat loss?
They both offer the same amount of b-AET. I wouldn't imagine the clary sage to offer more fat loss, but offer more in the sense of well being and reducing anxiety.
 
delsolrob

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thebigt

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It may be awhile...

Still using Invictus/7-Keto currently. I do plan on staying on a 1/2 dose of b-AET indefinitely though for the health benefits..
hope you stocked up on that 4th sale, killer savings...don't forget all of us reps have a code for 25% off all day, everyday!!!!
 
Ricky10

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hope you stocked up on that 4th sale, killer savings...don't forget all of us reps have a code for 25% off all day, everyday!!!!
No...afraid not :confused:

I don’t even remember the 4th of July. Oh, I had to work!
 
JulzRulz

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It may be awhile...

Still using Invictus/7-Keto currently. I do plan on staying on a 1/2 dose of b-AET indefinitely though for the health benefits..
When you say 1/2 dose you mean 0.5ml/day?
 
Ricky10

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why are you doing 1/2 a day? the package say .5 twice a day ... just curious
I always run it full dose - 0.5ml x 2 day (unless I get home too late) during my actual “cycles” of use for optimal body recomp effects. After this run though, I am going to continue using it at 1/2 dose for the general health and immune system benefits. Hoping this can be a weapon against catching viruses so often this upcoming season. I was sick 5-6 times last year...can’t do that again!

I may replace Invictus with Neuro AT at that time though..
 
Ricky10

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so i got sustain alpha and Neuro AET for libido and well being ... thoughts on this?
I have still never tried Sustain Alpha (only Dermacrine), but it seems to get rave reviews. That along with the proposed benefits of Neuro AET does sound like it would be just what you are looking for though!
 
cheftepesh1

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I have still never tried Sustain Alpha (only Dermacrine), but it seems to get rave reviews. That along with the proposed benefits of Neuro AET does sound like it would be just what you are looking for though!
For what he is looking for as far as benefits this would be a great combo. I’ve run both combos with excellent effects.
 
thebigt

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i got this and the SA (again)

have you used both in conjunction?
I haven't tried neuro AET yet, but Invictus/sustain always treats me well.

btw-thank you for your purchase!!!
 
thebigt

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I have still never tried Sustain Alpha (only Dermacrine), but it seems to get rave reviews. That along with the proposed benefits of Neuro AET does sound like it would be just what you are looking for though!
can't believe you haven't tried sustain...I trust you will love the libido boost-I know I do!!!
 
delsolrob

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Also, Iconic Formulations is now offering Neuro AET as part of the Neuro Series of products.

One of the updates for Neuro AET is the use of clary sage essential oils to offer synergy with the AET.

Clary sage has been shown to offer benefits for stress reduction/cortisol reduction and can also act as an antidepressant. Additionally, clary sage is also great for both men and women.
tell me what all this means ....
Androstenetriol (AET) is a potent modulator of cortisol. Neuro AET is a topical Androstenetriol product in Iron Legions topical delivery system (Salvo)...offerying 100mg/ml of b-AET. This product is amazing for modulating many of the adverse side effects of stress...from helping get restful sleep, to aiding in weight loss (there are many potential benefits - like in the article above...inflammation)

One of the differences in this product is the inclusion of Clary Sage. Clary Sage not only offers a gender neutral scent, but if offers other synergistic benefits for both men and women.

Some of the benefits users may get from clary sage:
  • Antidepressant
  • Anti-inflammatory
  • Stress relief
  • lower blood pressure
  • Lowered anxiety
  • Improved memory
  • greater alertness
  • anti bacterial
Initial findings also suggest it may be helpful in combating the effects of Alzheimer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/
 
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chem.jr.

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Androstenetriol (AET) is a potent modulator of cortisol. Neuro AET is a topical Androstenetriol product in Iron Legions topical delivery system (Salvo)...offerying 100mg/ml of b-AET. This product is amazing for modulating many of the adverse side effects of stress...from helping get restful sleep, to aiding in weight loss (there are many potential benefits - like in the article above...inflammation)

One of the differences in this product is the inclusion of Clary Sage. Clary Sage not only offers a gender neutral scent, but if offers other synergistic benefits for both men and women.

Some of the benefits users may get from clary sage:
  • Antidepressant
  • Anti-inflammatory
  • Stress relief
  • lower blood pressure
  • Lowered anxiety
  • Improved memory
  • greater alertness
  • anti bacterial
Initial findings also suggest it may be helpful in combating the effects of Alzheimer
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318325/
This sounds like it just may be perfect for those suffering with HIB as i call it or Lyme dis (RBC bacteria) bc it basically turns your brain to mush and makes everything stressfull and mood sucks etc. Always love 75/12mg dhea/preg and thinling this stacked w that may just take it to another level!
If you'd like to bless my father and I w a discount code pls PM me. We are broke bc we had to liquidate everything to pay for treatment so that kinda thing is severely appreciated by us. Hes almost 70 and would prolly benefit from this far greater than I. Would be happy to log Both* of our experiences if you like.

P.s.- post count/join date is incorrect bc i had to rejoin. Been on here for 8-10yrs at least. I forget at this point. Just saying I'm not a joker and take logging very seriously if that interests you at all. Anyways, thx for making such a product and being kick ass!
 
thebigt

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This sounds like it just may be perfect for those suffering with HIB as i call it or Lyme dis (RBC bacteria) bc it basically turns your brain to mush and makes everything stressfull and mood sucks etc. Always love 75/12mg dhea/preg and thinling this stacked w that may just take it to another level!
If you'd like to bless my father and I w a discount code pls PM me. We are broke bc we had to liquidate everything to pay for treatment so that kinda thing is severely appreciated by us. Hes almost 70 and would prolly benefit from this far greater than I. Would be happy to log Both* of our experiences if you like.

P.s.- post count/join date is incorrect bc i had to rejoin. Been on here for 8-10yrs at least. I forget at this point. Just saying I'm not a joker and take logging very seriously if that interests you at all. Anyways, thx for making such a product and being kick ass!
@delsorob handles this stuff...but as far as discount code THEBIGT will get you 25% off everything at both iconicformulations.com @ ironlegion.com.

sorry to hear about your run of bad times-i've been there!!!
 
thebigt

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This sounds like it just may be perfect for those suffering with HIB as i call it or Lyme dis (RBC bacteria) bc it basically turns your brain to mush and makes everything stressfull and mood sucks etc. Always love 75/12mg dhea/preg and thinling this stacked w that may just take it to another level!
If you'd like to bless my father and I w a discount code pls PM me. We are broke bc we had to liquidate everything to pay for treatment so that kinda thing is severely appreciated by us. Hes almost 70 and would prolly benefit from this far greater than I. Would be happy to log Both* of our experiences if you like.

P.s.- post count/join date is incorrect bc i had to rejoin. Been on here for 8-10yrs at least. I forget at this point. Just saying I'm not a joker and take logging very seriously if that interests you at all. Anyways, thx for making such a product and being kick ass!
@delsorob handles this stuff...but as far as discount code THEBIGT will get you 25% off everything at both iconicformulations.com @ ironlegion.com.

sorry to hear about your run of bad times-i've been there!!!
 

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How does AET compare the the PS in Endoamp as far as cortisol control? Stronger, different, just another means to the same end that might work better for some vs. the other? Endo has more huge benefits other than just cortisol control I very much realize but just curious.
 
delsolrob

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The mechanism, as I understand it, for PS modulating cortisol is by increasing neuro efficiency...these effects cascade down and one of the major benefits is reduced cortisol.

Neuro AET (androstenetriol) is a direct path product that directly impacts cortisol...and the effects are profound and people can notice benefit nearly immediately after beginning use. While AET does a great job of managing cortisol, users do not report many of the other benefits of PS (improved mental function, etc)
 

_Endure_

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The mechanism, as I understand it, for PS modulating cortisol is by increasing neuro efficiency...these effects cascade down and one of the major benefits is reduced cortisol.

Neuro AET (androstenetriol) is a direct path product that directly impacts cortisol...and the effects are profound and people can notice benefit nearly immediately after beginning use. While AET does a great job of managing cortisol, users do not report many of the other benefits of PS (improved mental function, etc)
Thanks Rob, that's what I figured that AET was much more targeted in it's mechanism strictly for cortisol and profound. While one of the many benefits of PS is also a regulation of it but not to such a dramatic extent.
 
thebigt

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Thanks Rob, that's what I figured that AET was much more targeted in it's mechanism strictly for cortisol and profound. While one of the many benefits of PS is also a regulation of it but not to such a dramatic extent.
for me the cort control is just icing on the cake with endoamp max....the improved brain function is substantial.
 

_Endure_

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for me the cort control is just icing on the cake with endoamp max....the improved brain function is substantial.
Yep agreed along with sleep and well being being through the roof.
 
delsolrob

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Any Idea where I can get this ? Its out of stock on Iconic's website.
just sent you a DM

I'm hoping we'll have more late next week or early the following
 
delsolrob

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lol, we were just having this convo over email.

DONE :)
 
thebigt

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I get a big increase in stamina, strength and feelings of well being when I take endoamp and b-aet, gyms are about open back up in my area so I'm excited.
lol...I can hear your excitement in your posts!!!

I love endoamp!!
 
delsolrob

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Thank you for the kind words! know that we're always here for you guys!
 

ramses31

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lol...I can hear your excitement in your posts!!!

I love endoamp!!
I notice a reduction in visceral fat when I take either products, my stress response gets much better, I feel much more explosive when I take endoamp which kind of surprised me but I like that effect, probably comes from an increase in neural drive.
 
thebigt

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I notice a reduction in visceral fat when I take either products, my stress response gets much better, I feel much more explosive when I take endoamp which kind of surprised me but I like that effect, probably comes from an increase in neural drive.
seriously, it is one of my favorite products...glad to hear it treats you well also.
 
delsolrob

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I notice a reduction in visceral fat when I take either products, my stress response gets much better, I feel much more explosive when I take endoamp which kind of surprised me but I like that effect, probably comes from an increase in neural drive.
please be sure to leave a review on these products...they are seriously lacking in feedback on the site. Neuro AET has one review and EndoAmp only has like 5 reviews. For how much people love endoamp, there's not much feedback.
 
thebigt

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please be sure to leave a review on these products...they are seriously lacking in feedback on the site. Neuro AET has one review and EndoAmp only has like 5 reviews. For how much people love endoamp, there's not much feedback.
I will be ordering some soon and will leave feedback.
 

ramses31

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please be sure to leave a review on these products...they are seriously lacking in feedback on the site. Neuro AET has one review and EndoAmp only has like 5 reviews. For how much people love endoamp, there's not much feedback.
No problem, I definitely will.
 

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Old thread I know but wanted to comment on this, I run b-aet for 2 years straight anything from a 1/4 to full dose a day. Before this I was getting allot of colds and every bug going, probably due to working in the health care industry, I stopped due to money issues the past 2 months and bang I have a cold.

also I never realised just how much this was keeping the fat off, probably because my job is highly Stressful so the cortisol lowering effects are defiantly a big help.
 
thebigt

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Old thread I know but wanted to comment on this, I run b-aet for 2 years straight anything from a 1/4 to full dose a day. Before this I was getting allot of colds and every bug going, probably due to working in the health care industry, I stopped due to money issues the past 2 months and bang I have a cold.

also I never realised just how much this was keeping the fat off, probably because my job is highly Stressful so the cortisol lowering effects are defiantly a big help.
flu season is here and covid is everywhere...i've been on neuro AET for over a month and starting 2nd bottle.
 

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