Thermogenic/weight loss agents...

[Alpine]

This is really more diet/supplement related but I put it here because it will get more views. If you must move it, sorry...

Here are a few little nuggets of info for those that are cutting (its that time of year again ) and also using well known weight loss or "thermogenic" compounds. For some, it just validates some things you may already know.

Bodybuilding Nutrition: Interview with Dr. Scott Connelly
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Fairly common knowledge:

"The only well-documented supplement combination to significantly
increase fat loss relative to energy loss— hence a true “supplement” effect— is the
ephedrine/caffeine protocol."

Other supplements [green tea, forskolin, HCA, etc.] have limited efficacy without a beta2 agonist
in combination. Synephrine is predominately an alpha agonist clinically and in my opinion is
more hazardous than ephedrine. Beta3 agonists have no clinical efficacy in human beings and
thus octopamine is virtually worthless. Other than certain drugs, PPAR agonists/inhibitors
(primarily modified fatty acids) have no documented efficacy to date regarding fat loss in
humans. Guggulsterones are worthless fat loss agents.

I found this last little bit rather interesting considering the ingredients of 90% of the supplements out there.

Looks like Green Tea + Ephedrine is still the way to go.

Disproportionate large quantities [of amino acids] consumed at single feedings increases oxidative loss of amino
acids as the system is geared to maintain individual plasma [blood] amino acid levels within
certain limits of one another. Flooding the plasma with large excesses above physiologic ranges
is immediately followed by irreversible oxidation of the excess.

Again, im glad he touched on this. All you really need to meet your BCAA needs is a quality protein shake throughout the day along with a good diet. Slamming BCAA's at mega doses is not all that effective. This has been mentioned before but its nice to have it from another reputable source. All the bastardizations and twisting of pubmed studies and other sources by supplement reps gets out of hand.